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KRAS and SKIL Mutations Jointly Drive Pancreatic Cancer by Degrading Smad4
Pancreatic cancer may gain its most dangerous advantages not from a single genetic alteration, but from a molecular partnership that dismantles one of the cell's key safeguards, according to a study published in the Journal of Experimental & Clinical Canc
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AKR1B10 Drives Breast Cancer Glycolysis and Growth Through IGF2R-PGK1-H4K12la-mTOR Signaling
A metabolic enzyme that helps breast-cancer cells turn sugar into fuel may also be rewiring gene activity to accelerate tumor growth, according to a study that maps an unexpected chain of molecular events from glycolysis to proliferation. The research ide
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Drone Imagery Reliably Identifies Trash and Tires for Aedes aegypti Breeding-Site Surveillance
A mosquito-control breakthrough may be taking shape above the rooftops of Kenya, where researchers have shown that high-resolution drone images can be used to identify discarded tires and accumulations of trash-two of the most important clues in the searc
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Study Compares BBB-Crossing AAV Capsids for Efficient Central Nervous System Delivery
A new study in mice has sharpened one of gene therapy's most stubborn problems: getting therapeutic genetic material across the blood-brain barrier without leaving large amounts of viral vector behind in the rest of the body. Researchers compared three en
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Modeling Reveals How Infant Gut Microbes May Affect Tyrosine Availability in Phenylketonuria
Phenylketonuria, or PKU, has long been understood as a disorder of a single missing enzymatic step. But a new study suggests that the condition's biology may also depend on an ecosystem living inside the intestine. Using computer models that combine infan
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