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Overview
Essays about biology and ml, written for and by owls. Click to read Owl Posting, by Abhishaike Mahajan, a Substack publication with tens of thousands of subscribers.
News
Why haven't organoids solved all of drug discovery?
Thank you to Jimmy Sastra and Kitchener D. Wilson for discussions relating to this piece. All opinions are my own. This essay is the first of three covering organoids. The full set is:Why haven't organoids solved all of drug discovery?UnreleasedUnreleased
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How to design a cancer vaccine (and vastly improve them): Alex Rubinsteyn & Ben Vincent
IntroductionTimestampsTranscriptApple PodcastsSpotifyIntroductionBack in early May, I flew to North Carolina to interview Alex Rubinsteyn (left) and Benjamin Vincent (right). Together, they run the Personalized Immunotherapy Research Lab (PIRL) at UNC-Cha
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The makings of a good bioweapon
Note: I've been traveling through Europe for the past week or so, and have not had time to finish my larger ongoing essays. So, this is a piece I wrote back in December 2025 about bioweapons programs. Also, a few friends and I are hosting an NYC meetup on
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How to build a cancer vaccine, and whether they will work this time
Grateful to Benjamin Vincent and Alex Rubinsteyn for our many conversations on this topic, and comments on drafts of this essay! Introduction The immunological theory behind cancer vaccinesThe past and present of TAA/CTA cancer vaccines The upcoming era o
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The ballad of TIGIT
There exist drug classes that seem, in retrospect, cursed. As these chemicals worm their way through the clinical trial system, they consume billions of dollars along the way, and squelch through thousands of sick patients. When finally it dawns on everyo
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