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KRAS and SKIL Mutations Jointly Drive Pancreatic Cancer by Degrading Smad4
Pancreatic cancer may gain its most dangerous advantages not from a single genetic alteration, but from a molecular partnership that dismantles one of the cell's key safeguards, according to a study published in the Journal of Experimental & Clinical Canc
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AKR1B10 Drives Breast Cancer Glycolysis and Growth Through IGF2R-PGK1-H4K12la-mTOR Signaling
A metabolic enzyme that helps breast-cancer cells turn sugar into fuel may also be rewiring gene activity to accelerate tumor growth, according to a study that maps an unexpected chain of molecular events from glycolysis to proliferation. The research ide
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Drone Imagery Reliably Identifies Trash and Tires for Aedes aegypti Breeding-Site Surveillance
A mosquito-control breakthrough may be taking shape above the rooftops of Kenya, where researchers have shown that high-resolution drone images can be used to identify discarded tires and accumulations of trash-two of the most important clues in the searc
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Study Compares BBB-Crossing AAV Capsids for Efficient Central Nervous System Delivery
A new study in mice has sharpened one of gene therapy's most stubborn problems: getting therapeutic genetic material across the blood-brain barrier without leaving large amounts of viral vector behind in the rest of the body. Researchers compared three en
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Modeling Reveals How Infant Gut Microbes May Affect Tyrosine Availability in Phenylketonuria
Phenylketonuria, or PKU, has long been understood as a disorder of a single missing enzymatic step. But a new study suggests that the condition's biology may also depend on an ecosystem living inside the intestine. Using computer models that combine infan
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Brief diet-exercise interventions alter CD86-Faecalibaculum link to adipose inflammation after high-fat diets
A brief change in diet and exercise may help untangle the inflammatory damage associated with long-term high-fat eating, according to a mouse study that links immune cells in fat tissue with specific gut bacteria. The research, published in Gut Pathogens,
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Chlorine-Free Bleaching Produces Cellulose Nanofibers from Sugar Beet Pulp
Sugar beet pulp, the fibrous residue left behind after sugar is extracted from beets, could become the raw material for advanced sustainable biomaterials under a new chlorine-free processing route. Researchers at the University of Copenhagen have shown th
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flexiAsCas12a and Other Variants Expand Cas12a Nuclease Applications in Prime Editing
A new generation of CRISPR genome-editing enzymes could make it possible to rewrite DNA sequences that have remained out of reach for one of the field's most precise technologies. Researchers in Hungary have developed a series of Cas12a variants with more
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Metabolic mapping reveals spatially distinct host carbon reprogramming during Trichinella spiralis infection
A Parasitic Worm Rewires Metabolism in Two Places at Once, Study Finds A parasitic infection caused by Trichinella spiralis appears to reprogram the host's metabolism differently in the bloodstream and the intestine, according to a mouse study that offers
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Hydroponic Platform Reveals Grass Nodal Root Development, Cell Wall Thickening, Hormone Responses
Scientists have developed a hydroponic platform that makes it possible to watch and measure a part of grass biology that has long been difficult to study: the development of nodal roots emerging from the plant's stem. The system, described in Plant Method
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