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Overview
Case-based studies and essays on blood that cover historical perspectives, the identity crisis of the hematologist, the definition of blood disease as a construct, fascinating blood tales in nature, and more.
News
Iron Toxicity and Iron Overload in Transfused Hemoglobinopathies
In this video lecture, Dr. Thomas Coates discusses: How non-transferrin-bound and reactive iron drive tissue toxicity in transfused hemoglobinopathies. How erythropoietic activity, transferrin saturation, and duration of iron exposure influence organ dama
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Gene Therapy for Beta Thalassemia
In this video lecture, Dr. Janet Kwiatkowski discusses: How gene therapy addresses the globin-chain imbalance underlying transfusion-dependent beta-thalassemia. The mechanisms and clinical outcomes of approved gene addition and CRISPR-Cas9 gene editing ap
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Complications of Thalassemia
In this video lecture, Professor Khaled Musallam discusses: How complication profiles differ between non-transfusion-dependent and transfusion-dependent thalassemia. The roles of chronic anemia, iron overload, and hypercoagulability in driving morbidity i
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Fibrinogen Deficiencies
In this video lecture, Dr. Alessandro Casini discusses: The diagnostic approach to quantitative and qualitative hereditary fibrinogen disorders using fibrinogen activity, antigen, and genetic testing. How fibrinogen level, genotype, and clot properties co
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Diagnosis of Select Rare Coagulation Disorders
In this video lecture, Dr. Amy Shapiro discusses: The diagnosis of factor XIII deficiency and rare disorders affecting key components of the fibrinolytic pathway. The distinct clinical and laboratory features of alpha-2 antiplasmin, PAI-1, and plasminogen
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