{"id":2736344,"url":"https://alion.io/job/abogenbio-sr-or-pri-scientist-protein-engineering","title":"Sr or Pri Scientist, Protein Engineering","company":{"id":2067005,"name":"Abogen Biosciences","domain":"abogenbio.com","url":"https://alion.io/company/abogenbio","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Moka","truth_index":{"grade":"A","score":88,"open_postings":12,"ghost_share":0,"stale_share":0.5,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-26T05:57:25Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Suzhou, China"],"countries":["CN"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":27000,"max_usd":62000,"period":"year","method":"global_role_cell_scaled_by_country","sample_n":1296},"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-08-24T10:32:57Z","employer_posted_date":"2026-08-31","last_verified_at":"2026-10-26T18:48:35Z","board_verified":true,"closed_at":null,"days_open":63,"trust":{"level":"ok","repost_count":0,"flags":[],"days_open":62},"description":"Responsibilities\n1.Design novel or engineered protein variants (antibodies, enzymes, binders, scaffolds, or other biologics) using structure-based design, molecular dynamics, and generative deep learning (e.g., RFdiffusion, ProteinMPNN, ESM, AlphaProteo, or internally developed architectures);\n2.Design and optimize protein antigens and therapeutic proteins for mRNA-encoded expression, including sequence-humanization, stability engineering, and developability assessment to ensure efficient in vivo translation and expression from LNP-delivered mRNA;\n3.Build and apply predictive models for protein stability, binding affinity, specificity, immunogenicity, developability, and expression;\n4.Design and prioritize variant libraries for high-throughput screening and directed evolution campaigns (including language-model-guided evolution, e.g., EVOLVEpro);\n5.Benchmark and integrate new structure-prediction and design models as the field evolves (e.g., AlphaFold3, Chai, Boltz-2);\n6.Collaborate closely with platform teams to translate computational predictions into experimental designs;\n7.Communicate findings, model performance, and design rationale clearly to both computational and experimental stakeholders, including cross-functional and leadership audiences;\n8.(Principal level) Set technical strategy for computational protein design efforts, mentor junior scientists, and represent the computational function in cross-functional program planning.\nRequirements\n1.PhD in Computational Biology, Biophysics, Bioengineering, Computer Science, Computational Chemistry, or a related field.\n2.5+ years (Senior) or 8+ years (Principal) of hands-on experience in computational protein design/engineering in an academic or industry setting.\n3.Deep familiarity with protein structure prediction and design tools (e.g., Rosetta, AlphaFold/AlphaFold-Multimer, RFdiffusion, ProteinMPNN, ESM, Chai, Boltz) and molecular dynamics simulation (e.g., GROMACS, OpenMM, Desmond).\n4.Strong programming skills; experience building and maintaining computational pipelines.\n5.Experience partnering with wet-lab teams to design experiments and interpret biophysical/functional data.\n6.Track record of taking computational designs from hypothesis through experimental validation, ideally within a therapeutic or industrial biologics context.\n7.Excellent written and verbal communication skills; ability to explain computational concepts to non-computational colleagues.\n8.Publication record and/or patents in protein engineering, structural biology, or computational biology is a plus.","description_format":"text","description_chars":2570,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Financial Services","Health Care"],"lifecycle":[{"event":"open","at":"2026-10-16T19:10:08Z"}],"visa":[],"liveness":{"score":10,"band":"cold","label":"Long shot","p_open":1,"p_active":0.345,"p_room":0.28,"age_days":62,"expected_fill_days":28,"reasons":["conf:1","stale_co","win:tail","crowd:"],"computed_at":"2026-10-26T05:57:25Z"},"pay":null,"html_url":"https://alion.io/job/abogenbio-sr-or-pri-scientist-protein-engineering","json_url":"https://alion.io/job/abogenbio-sr-or-pri-scientist-protein-engineering.json","meta":{"generated_at":"2026-10-26T23:33:07Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":32195,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-27T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2067005},"rest":"https://alion.io/mcp/rest/get_company?id=2067005"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fabogenbio-sr-or-pri-scientist-protein-engineering"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fabogenbio-sr-or-pri-scientist-protein-engineering"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fabogenbio-sr-or-pri-scientist-protein-engineering"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/abogenbio-sr-or-pri-scientist-protein-engineering\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fabogenbio-sr-or-pri-scientist-protein-engineering"}]}