{"id":3652793,"url":"https://alion.io/job/abzena-sr-manager-bioconjugation-development","title":"Sr Manager, Bioconjugation Development","company":{"id":2138905,"name":"Abzena","domain":"abzena.com","url":"https://alion.io/company/abzena","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"A","score":91,"open_postings":8,"ghost_share":0,"stale_share":0.375,"repost_share":0,"time_to_fill_p50_days":36,"computed_at":"2026-11-08T05:47:12Z"}},"role":"HR","role_family":"HR","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Bristol, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CAPA","optional":false},{"name":"Chromatography","optional":false},{"name":"Design of Experiments","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-11-02T22:15:06Z","employer_posted_date":"2026-11-02","last_verified_at":"2026-11-08T04:38:41Z","board_verified":true,"closed_at":null,"days_open":5,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":5},"description":"The Senior Manager, Bioconjugation is a people leader, program leader, and scientific-technical leader responsible for the successful execution of assigned bioconjugation process development programs. Reporting to the Head of Bioconjugation Development, this role leads and develops a team of scientists, serves as the primary technical point of contact for assigned customers, and ensures delivery of robust, scalable, phase-appropriate processes for various process development programs. This role is also accountable for strengthening day-to-day operating discipline in the Process Development laboratory, including procedural adherence, contemporaneous and complete documentation, data integrity, rigorous data analysis and reporting, laboratory safety, and 5S standards.\nResponsibilities\nPeople Leadership, Coaching, and Performance\nLead, coach, and develop direct reports, including Principal Scientists and other scientific staff, through clear objectives, regular feedback, development planning, and differentiated accountability.\n\nEstablish clear expectations for scientific quality, execution discipline, collaboration, customer focus, and ownership; address performance or behavioral gaps promptly and constructively.\n\nBuild technical depth and succession capability through mentoring, knowledge sharing, cross-training, and purposeful delegation.\n\nPlan and allocate resources across assigned programs, balancing customer commitments, technical risk, laboratory capacity, and employee development.\n\nCreate an inclusive, respectful, and high-accountability team environment in which issues are surfaced early and resolved at the appropriate level.\n\nProgram and Customer Leadership\nLead end-to-end execution of assigned bioconjugation Process Development programs across conjugation chemistry, downstream purification, scale-up, process analytics, technology transfer, and manufacturing support.\n\nServe as the primary scientific and technical point of contact for assigned customer programs; communicate program status, data, conclusions, recommendations, risks, decisions, and mitigation plans with clarity and credibility.\n\nCoordinate cross-functional teams spanning Analytical Services, MSAT, Manufacturing, Quality, Regulatory Affairs, Project Management, and other functions to deliver integrated program outcomes.\n\nEstablish development strategies, technical milestones, decision points, and program priorities; ensure effective use of resources and timely escalation of risks or scope changes.\n\nDrive proactive issue resolution using structured data review, root-cause thinking, risk assessment, and documented action plans.\n\nEnsure successful scale-up, technology transfer, and manufacturing support, including readiness assessments, process risk reviews, training, and review of master batch records and supporting technical documentation.\n\nScientific and Technical Leadership\nApply strong understanding of bioconjugation chemistry and bioprocess engineering and provide scientific direction for the development of robust, reproducible, scalable, and manufacturable bioconjugation and purification processes.\n\nGuide experimental strategy, including use of design of experiments (DoE), process characterization, critical process parameter evaluation, scale-down models, and phase-appropriate control strategies.\n\nEnsure technical conclusions and recommendations are evidence-based, appropriately qualified, and connected to customer, quality, regulatory, and manufacturing requirements.\n\nChampion platform technologies, standard work, process improvements, and innovative approaches that improve robustness, speed, reproducibility, and knowledge transfer.\n\nProvide on-the-floor or in-lab scientific support for complex development, scale-up, technology transfer, and manufacturing activities as needed.\n\nDocumentation, Data, Safety, and Laboratory Standards\nOwn team adherence to approved procedures, protocols, SOPs, and established development workflows; verify that work is performed as written and that deviations are identified, escalated, and addressed.\n\nEnsure laboratory notebooks, electronic records, protocols, development reports, batch records, technical presentations, and other documents are complete, accurate, contemporaneous, traceable, and reviewed on time.\n\nRaise the standard of data analysis and reporting by requiring appropriate calculations, statistical treatment, data visualization, interpretation, conclusions, and linkage to predefined objectives and acceptance criteria.\n\nImplement routine technical and documentation reviews to improve right-first-time quality and prevent incomplete records, unsupported conclusions, transcription errors, and late reports.\n\nLead and sustain 5S in the Process Development laboratory, including ownership for organization, labeling, material and equipment control, housekeeping, visual standards, and routine audits.\n\nPromote a strong safety culture by identifying and correcting unsafe conditions, reinforcing safe work practices, ensuring completion of required risk assessments and training, and stopping work when conditions are not safe.\n\nPartner with Quality and EHS to ensure compliance with applicable GxP expectations, company policies, procedures, and laboratory safety requirements.\n\nOrganizational Contribution\nSupport scientific and commercial activities, including technical scoping, proposal development, customer discussions, and bid defenses, as assigned.\n\nParticipate in recruiting, interviewing, onboarding, and capability-building for the Bioconjugation Process Development organization.\n\nMaintain current knowledge of advances in bioconjugation, bioprocessing, analytical technologies, and relevant regulatory expectations.\n\nCommunicate effectively with customers, colleagues, leaders, and staff; operate to high ethical standards and perform other duties as assigned.\n\nQualifications\nPhD in chemistry, biochemistry, bioorganic chemistry, chemical biology, chemical engineering, biochemical engineering, or a related discipline, with typically 8+ years of relevant industry experience; or an MS with typically 12+ years of relevant industry experience. Equivalent combinations of education and experience may be considered.\n\nDemonstrated expertise in bioconjugation or biotherapeutic conjugate process development, such as ADCs, AOCs/ARCs, PDCs, DACs, or related modalities.\n\nPrior experience leading scientists and technical teams, including direct people-management responsibility or substantial team-lead experience with readiness to assume direct people leadership.\n\nDemonstrated success as a customer-facing technical or program lead in a CDMO, biotechnology, or pharmaceutical environment.\n\nHands-on experience with conjugation process development, preparative chromatography, normal-flow filtration, TFF/UF-DF, scale-up, and technology transfer.\n\nWorking knowledge of cGMP operations, GxP principles, development documentation, data integrity, and phase-appropriate CMC expectations.\n\nExperience applying DoE, statistical analysis, data visualization, and structured technical report writing to process-development decisions.\n\nStrong communication, conflict-resolution, prioritization, and decision-making skills, with the ability to lead across functions without relying solely on formal authority.\n\nPreferred:\nExperience developing and transferring bioconjugation processes from bench through pilot, toxicology, clinical, or GMP manufacturing scale.\n\nExperience with large-scale and single-use bioprocess equipment, including process vessels, pumps, biowelders, biosealers, rocker systems, chromatography skids, and single-use assemblies.\n\nExperience leading laboratory 5S, continuous-improvement, documentation-quality, or safety-culture initiatives.\n\nExperience supporting regulatory filings, process validation strategy, deviation investigations, CAPA, or manufacturing troubleshooting.","description_format":"text","description_chars":7899,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["CRO & CDMO Services"],"lifecycle":[{"event":"open","at":"2026-11-03T00:39:42Z"}],"visa":[],"liveness":{"score":95,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.946,"p_room":1,"age_days":5,"expected_fill_days":36,"reasons":["conf:1","urgency","win:early"],"computed_at":"2026-11-08T05:47:12Z"},"pay":null,"html_url":"https://alion.io/job/abzena-sr-manager-bioconjugation-development","json_url":"https://alion.io/job/abzena-sr-manager-bioconjugation-development.json","meta":{"generated_at":"2026-11-08T07:29:48Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":16319,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-09T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2138905},"rest":"https://alion.io/mcp/rest/get_company?id=2138905"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fabzena-sr-manager-bioconjugation-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fabzena-sr-manager-bioconjugation-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fabzena-sr-manager-bioconjugation-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/abzena-sr-manager-bioconjugation-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fabzena-sr-manager-bioconjugation-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3652793}},{"tool":"search_jobs","arguments":{"company":"abzena.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3652793},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}