{"id":3652790,"url":"https://alion.io/job/abzena-sr-scientist-bioconjugation","title":"Sr Scientist, Bioconjugation","company":{"id":2138905,"name":"Abzena","domain":"abzena.com","url":"https://alion.io/company/abzena","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"A","score":88,"open_postings":6,"ghost_share":0,"stale_share":0.5,"repost_share":0,"time_to_fill_p50_days":36,"computed_at":"2026-11-03T05:54:40Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Bristol, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"GMP","optional":false},{"name":"HPLC","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-11-02T22:33:55Z","employer_posted_date":"2026-11-02","last_verified_at":"2026-11-04T00:23:52Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"The Bioconjugation Process Development Senior Scientist is responsible for leading bioconjugation downstream process development activities to support Abzena Bristol’s development and manufacturing operations.\nResponsibilities\nOperate to the highest ethical and moral standards.\n\nComply with Abzena's policies and procedures.\n\nCommunicate effectively with clients, supervisors, colleagues and staff.\n\nParticipate effectively as a team player in all aspects of Abzena's business.\n\nAdhere to quality standards set by regulations and Abzena policies, procedures, and mission.\n\nPerform other duties as assigned.\n\nContribute to assigned laboratory operations including instrument and equipment operations, material shipment preparation, consumables procurement.\n\nFocus on developing downstream conjugation bioprocesses to manufacture conjugated biotherapeutics including antibody-drug conjugates, conjugate vaccines, protein-oligonucleotide conjugates, peptide-protein conjugates, chelator-antibody conjugates, etc.\n\nWork collaboratively in the development, optimization, and scale-up of bioconjugation reactions, purification steps, and characterization approaches for conjugate biotherapies.\n\nHands-on execution of chromatographic purifications (affinity, hydrophobic interaction, and ion exchange chromatography), membrane filtrations (normal and tangential flow filtrations), buffer and solution preparation, conjugation reaction work-up.\n\nPerform, develop and optimize bioanalytical characterization (HPLC, UPLC, LC-MS, MALDI, MALS, colorimetric assays, etc.) of bioconjugate products.\n\nAuthoring and review of relevant documentation including laboratory notebooks, process development reports, protocols, batch records, SOPs, technical presentations.\n\nMaintain strong technical understanding of advancements in bioconjugation/bioprocessing through literature searches and review.\n\nServe independently as bioconjugation PD technical lead and subject-matter expert for internal and external project communications.\n\nManagement and supervision of technical team line reports.\n\nQualifications\nA PhD or BS/MS degree in biochemical sciences or bio-engineering with industry experience (>1 year + PhD, >3 years + MS/BS) in biotherapeutic development or bioconjugation.\n\nExperience in preparative purification of biological molecules (antibodies, carrier proteins, viruses, viral vectors, or other biological molecules).\n\nExpertise in normal flow filtrations and tangential flow filtrations (TFF, UF/DF).\n\nKnowledge of strategies for the optimization of bioprocesses and experimental design (DoE).\n\nThorough hands-on experience with preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer, etc.), and manual or automated TFF skids.\n\nExpertise with quantitative determination of scalable process parameters for normal flow filtrations, tangential flow filtrations, and preparative chromatographic separations.\n\nKnowledge of cGMP manufacturing operations and GxP principles.\n\nStrong knowledge of bioconjugation reactions, techniques and approaches.\n\nExperience with protein bioanalytical techniques (HPLC, LC-MS, UV-spectrophotometry, etc.)\n\nExperience with large scale bioprocess equipment (pallet tanks, pumps, biowelders, biosealers, bio-rockers, single-use assemblies).","description_format":"text","description_chars":3282,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["CRO & CDMO Services"],"lifecycle":[{"event":"open","at":"2026-11-03T00:39:42Z"}],"visa":[],"liveness":{"score":95,"band":"hot","label":"Hiring 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