{"id":4044319,"url":"https://alion.io/job/abzena-sr-scientist-lcms","title":"Sr Scientist, LCMS","company":{"id":2138905,"name":"Abzena","domain":"abzena.com","url":"https://alion.io/company/abzena","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"A","score":86,"open_postings":9,"ghost_share":0,"stale_share":0.556,"repost_share":0,"time_to_fill_p50_days":36,"computed_at":"2026-11-12T10:38:37Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Bristol, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Mass Spectrometry","optional":false},{"name":"GMP","optional":true}],"status":"live","first_seen_at":"2026-11-10T18:09:48Z","employer_posted_date":"2026-11-10","last_verified_at":"2026-11-12T10:53:04Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"We are seeking an experienced LC-MS scientist to develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities. This individual will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.\nThe successful candidate will play a key role in developing and implementing advanced LC-MS workflows for structural characterization, impurity analysis, linker-payload assessment, DAR determination, peptide mapping, and comparability studies to support clinical development programs.\nResponsibilities\nLead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugate therapeutics.\nDesign and execute mass spectrometry studies for characterization of intact proteins/antibodies, fragment antibodies, small format proteins, peptides, linker-payloads, oligonucleotides, and conjugated species.\nPerform characterization activities including DAR analysis, peptide mapping, PTM identification, conjugation site analysis, aggregation and fragmentation assessment, disulfide scrambling, free payload and linker impurity analysis, and stability studies. \nSupport analytical investigations related to process development, manufacturing deviations, comparability, and product quality assessments.\nCollaborate closely with process development, bioassay, formulation, and quality teams to establish analytical control strategies and critical quality attributes (CQAs). \nDevelop robust sample preparation workflows for proteins, peptides, oligonucleotides, and conjugated modalities for LC-MS analyses.\nInterpret complex analytical datasets and communicate findings to cross-functional project teams and client sponsors.\nAuthor technical reports, analytical development summaries, regulatory documentation, SOPs, protocols, and method qualification reports. \nSupport regulatory submissions including IND, BLA, and IMPD analytical sections.\nMaintain instrumentation including general maintenance, troubleshooting and scheduling of performative maintenance and vendor repair services. \nQualifications\nPh.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 0 years of industry experience; or M.S. with 2+ years of relevant experience.\nExtensive hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.\nHands-on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.\nExperience with analytical characterization techniques including intact/reduced, subunit mass analysis, and peptide mapping. \nStrong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development. \nExperience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms. \nExcellent technical writing, problem-solving, and communication skills. \nPreferred Qualifications\nExperience specifically supporting ADCs, AOCs, radioconjugates, or oligonucleotide therapeutics.\nFamiliarity with linker-payload chemistry and conjugation process development.\nExperience with multi-attribute methods (MAM) and advanced characterization workflows. \nKnowledge of regulatory expectations for biologics and conjugated therapeutics. \nExperience supporting method qualification, validation, and comparability studies.\nDemonstrated experience supporting CMC development and CGMP environments. \nPrior experience working with CDMOs and external analytical laboratories.","description_format":"text","description_chars":3690,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["CRO & CDMO Services"],"lifecycle":[{"event":"open","at":"2026-11-10T23:18:03Z"}],"visa":[],"liveness":{"score":95,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.946,"p_room":1,"age_days":1,"expected_fill_days":36,"reasons":["conf:5","urgency","win:early"],"computed_at":"2026-11-12T10:38:37Z"},"pay":null,"html_url":"https://alion.io/job/abzena-sr-scientist-lcms","json_url":"https://alion.io/job/abzena-sr-scientist-lcms.json","meta":{"generated_at":"2026-11-12T16:09:23Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":33781,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-13T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2138905},"rest":"https://alion.io/mcp/rest/get_company?id=2138905"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fabzena-sr-scientist-lcms"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fabzena-sr-scientist-lcms"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fabzena-sr-scientist-lcms"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/abzena-sr-scientist-lcms\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fabzena-sr-scientist-lcms"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":4044319}},{"tool":"search_jobs","arguments":{"company":"abzena.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":4044319},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); 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