Research Associate RA/Sr. RA - RNA Process Development and Manufacturing

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Job description:

Addition Therapeutics is seeking a highly motivated scientist with experience in RNA or related modality manufacturing. This position is at the Research Associate/Senior Research Associate level. The ideal candidate will contribute to RNA production and broad operationalization of the production process.  The successful candidate is detailed-oriented and who is excited by new challenges and cross-functional teamwork. This position has vast learning opportunities in the field of permanent gene insertion into the genome.

About the Role: The day-to-day responsibilities of this role will include but are not limited to:

• Producing RNA in small to mid-scale sized reactions
• Preparing reagents, sub-aliquoting, maintaining reagent logs and inventory
• Supporting reagent selection and vendor qualification
• Contribute to creating and documenting protocols and techniques.
• Collaborate with the analytical team to determine purity and levels of undesired impurities in DNA and RNA products.
• Support QC assays
• Collect and prepare accurate and timely data summaries and review written reports.
• Stay current with relevant scientific literature and implement new techniques or practices to improve quality and efficiency

Requirements:

Highly desired:

• Experience with manufacturing DNA, RNA or gene therapy related modalities (GMP or non-GMP)
• Good documentation practice with experience in an electronic notebook
• Thrives in a fast-moving, results-oriented startup environment
• Self-motivated, passionate, and eager to continuously learn
• Experience with external vendor communications.

Significant Plus:

• Experience with tangential flow filtration, AKTA purification, and bioreactors
• Experience with QC assays including Qubit, Fragment Analyzer, LAL Endotoxin
• Familiarity and hands-on experience in molecular biology and cell biology
• Familiarity with JMP statistical software

Education: Bachelor’s or master’s degree in chemistry, Biochemistry or related field with 2-4 years of experience 

Compensation: The hourly rate for this position is $55-$70.

Location: South San Francisco, California

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.