{"id":2413564,"url":"https://alion.io/job/alector-scientist-biology","title":"Scientist, Biology","company":{"id":2939952,"name":"Alector","domain":"alector.com","url":"https://alion.io/company/alector","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":145000,"max":155000,"currency":"USD","period":"year","gross":null,"usd_annual":155000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-10-12T23:49:42Z","employer_posted_date":"2026-10-12","last_verified_at":"2026-10-15T08:28:07Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"As a Scientist on our Biology team, you will design and execute in vitro studies and analytical assays that help us evaluate potential therapeutics for neurodegenerative diseases. You will work with advanced cellular models, process in vivo and in vitro samples, and generate high-quality data that inform pharmacokinetics/pharmacodynamics (PK/PD), efficacy, safety, proof-of-concept (POC), and mechanism-of-action (MOA) studies.\nYou’ll collaborate closely with colleagues across Biology, ADPE, and Preclinical teams to advance our programs. We value scientific curiosity, thoughtful experimentation, and the ability to adapt as our science and priorities evolve.\nKey Goals and Accountabilities\nAdvance our therapeutic programs!Design and execute in vitro pharmacology studies using iPSC-derived cellular models, including induced neurons, induced microglia, and co-culture and triple-culture systems.\n\nBuild disease-relevant models!Develop and optimize cellular models of neurodegenerative disease, including Alzheimer’s disease, to enable POC and MOA studies.\n\nGenerate decision-driving data!Collect and process cell lysates, media, rodent brain, and other biological samples and perform downstream biochemical and cellular analyses.\n\nTurn experiments into shared insights!Analyze, interpret, document, and communicate results while maintaining accurate experimental records, protocols, and data in our electronic lab notebook.\n\nAccelerate how we do science!Collaborate across Biology, ADPE, and Preclinical teams while identifying opportunities to integrate innovative technologies, especially AI, to expedite programs, improve scientific workflows, and save valuable resources.\n\nRequired Qualifications\nPhD in Neuroscience, Immunology, Biology, or a related scientific discipline.\n\nHands-on experience with cell culture, including iPSC-derived and/or primary rodent neuronal models.\n\nExperience with biochemical and cellular techniques such as immunoblotting, ELISA, MSD, immunocytochemistry, flow cytometry/FACS, or immunohistochemistry.\n\nDemonstrated ability to analyze and interpret experimental data and clearly communicate scientific findings.\n\nYou are an active user of large language models (LLMs) and have a strong interest in evolving AI technologies and how they can improve scientific research and productivity.\n\nPreferred Qualifications\nExperience working in a biotechnology or pharmaceutical research environment.\n\nExperience developing or optimizing cellular models of neurodegenerative 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