{"id":2326666,"url":"https://alion.io/job/alector-senior-associate-scientist-bioanalytical-sciences","title":"Senior Associate Scientist, Bioanalytical Sciences","company":{"id":2939952,"name":"Alector","domain":"alector.com","url":"https://alion.io/company/alector","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":125000,"max":140000,"currency":"USD","period":"year","gross":null,"usd_annual":140000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-09-02T18:17:03Z","employer_posted_date":"2026-09-02","last_verified_at":"2026-10-13T09:13:15Z","board_verified":true,"closed_at":null,"days_open":40,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":40},"description":"This role is based at Alector’s headquarters in South San Francisco, CA. Regular onsite presence is essential given the combination of hands-on laboratory work, scientific leadership, and close collaboration with multidisciplinary teams\nWe are seeking a Senior Associate Scientist, Bioanalytical Sciences to support bioanalytical assay development and execution across Alector’s nonclinical and clinical programs. You will be a hands-on laboratory scientist responsible for independently developing, optimizing, troubleshooting, and qualifying bioanalytical assays while also managing selected activities performed at external CROs.\nYou will bring strong experience with ligand-binding assays for pharmacokinetic, immunogenicity and biomarker assessments, including independent, hands-on development of PK, anti-drug antibody (ADA) and/or biomarker assays in biological samples such as CSF, serum/plasma, and tissue lysates. You must also have direct bioanalytical experience supporting a range of therapeutic modalities, such as antibodies, bispecific antibodies, and/or conjugated siRNA/ASOs.\nThis is an individual-contributor position with no people-management responsibilities. You will work closely with colleagues across Research, Toxicology, Clinical Development, and external partners to generate high-quality bioanalytical data that supports program decisions.\nKey Goals & Accountabilities\nIndependently develop PK, ADA and biomarker assays! Design, develop, optimize, troubleshoot, and qualify ligand-binding assays across biological matrices including CSF, serum/plasma, and tissue lysates.\nSupport diverse therapeutic modalities! Apply your bioanalytical expertise to antibodies, bispecific antibodies, conjugated siRNAs, and other emerging therapeutic approaches.\nStay hands-on in the laboratory! Plan and execute experiments using platforms such as ELISA and MSD, evaluate assay performance, investigate matrix effects and interference, and deliver reproducible, decision-ready data.\nManage external bioanalytical work! Coordinate assay transfer, validation, sample analysis, troubleshooting, data review, timelines, and study deliverables with CRO partners while maintaining scientific ownership and supporting work conducted in accordance with applicable GLP and regulatory expectations.\nHelp us work smarter! Integrate innovative technologies-including laboratory automation, AI, and large language models-to accelerate assay development, improve quality, and use resources more effectively!\nRequired Qualifications\nBS in Biology, Biochemistry, Pharmacology, Immunology, or a related scientific discipline with 5+ years of relevant biotechnology or pharmaceutical industry experience, or an MS in a related scientific discipline with 3+ years of relevant industry experience.Demonstrated ability to independently develop PK, ADA and/or biomarker assays in biological samples including CSF, serum/plasma, and tissue lysates. You have hands-on experience designing, developing, optimizing, troubleshooting, and qualifying assays rather than only executing established methods.\nDirect bioanalytical experience supporting therapeutic modalities such as antibodies, bispecific antibodies, and/or conjugated siRNA is required.\nStrong hands-on experience with ligand-binding assay platforms such as ELISA and MSD, including evaluation of sensitivity, selectivity, precision, matrix effects, drug tolerance, and assay interference.\nExperience authoring and reviewing bioanalytical method protocols, qualification and validation plans, SOPs, data summaries, and technical reports.\nStrong knowledge of GLP requirements and regulatory guidance from FDA, ICH, and EMA related to bioanalytical assay development, qualification, and validation.\nExperience working with external CROs on assay transfer, validation, sample analysis, troubleshooting, and data review; strong experimental documentation and communication skills; and active use of large language models with a strong interest in evolving AI\nPreferred Qualifications\nExperience developing neutralizing antibody assays or other immunogenicity assessments.\nExperience supporting regulated bioanalytical method validation and sample analysis.\nExperience with automated liquid- or sample-handling platforms such as Agilent Bravo, Hamilton or Tecan.\nExperience in Gyrolab and fit-for-purpose biomarker assay qualification\nExperience with Benchling, Watson LIMS, Graphpad Prism, Softmax Pro or comparable electronic laboratory and bioanalytical data systems.\nExperience introducing new assay technologies, automation, or data-analysis approaches into laboratory workflows.\nCollaboration\nYou will partner closely with colleagues across Research, Toxicology, Clinical Development, and other multidisciplinary teams. We expect you to communicate experimental results, assay limitations, risks, and recommendations clearly. We share knowledge openly, solve problems together, and adapt quickly as program needs evolve.","description_format":"text","description_chars":4972,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Health Care","Neurology & CNS Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-12T07:35:51Z"}],"visa":[],"liveness":{"score":18,"band":"cold","label":"Long shot","p_open":1,"p_active":0.501,"p_room":0.36,"age_days":40,"expected_fill_days":24,"reasons":["conf:0","win:tail","crowd:junior"],"computed_at":"2026-10-13T05:45:00Z"},"pay":{"stated_usd_annual":140000,"is_top_pay":true},"html_url":"https://alion.io/job/alector-senior-associate-scientist-bioanalytical-sciences","json_url":"https://alion.io/job/alector-senior-associate-scientist-bioanalytical-sciences.json","meta":{"generated_at":"2026-10-13T10:32:38Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":16126,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-14T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2939952},"rest":"https://alion.io/mcp/rest/get_company?id=2939952"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Falector-senior-associate-scientist-bioanalytical-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Falector-senior-associate-scientist-bioanalytical-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Falector-senior-associate-scientist-bioanalytical-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/alector-senior-associate-scientist-bioanalytical-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Falector-senior-associate-scientist-bioanalytical-sciences"}]}