{"id":879267,"url":"https://alion.io/job/alltrna-vp-program-management-business-operations","title":"VP, Program Management & Business Operations","company":{"id":670770,"name":"Alltrna","domain":"alltrna.com","url":"https://alion.io/company/alltrna","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Operations","role_family":"Operations","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":250000,"max":330000,"currency":"USD","period":"year","gross":null,"usd_annual":330000},"salary_estimate":null,"experience_years_min":15,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-05-06T17:44:27Z","employer_posted_date":"2026-10-05","last_verified_at":"2026-10-21T11:36:01Z","board_verified":true,"closed_at":null,"days_open":167,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":167},"description":"About Alltrna \nAlltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.\nAlltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. \nFor more information, visit www.alltrna.com\nVP, Director Program Management & Business Operations\nPosition Summary:\nAlltrna is seeking a talented and highly motivated VP. Director Program Management and Business Operations, reporting to the President & CFO. The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.\nKey Responsibilities:\nProgram Management:\nWork closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability\nPossess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets\nIdentify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members\nEnsure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate\nWork closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans\nInterface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.\nBe the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines\nPoint person for alliance management and coordination, as needed\nLead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings\nOperations:\nCollaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions\nDevelop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making\nPrepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals\nLead the Scientific Communications process, working with the Scientific Communications Committee\nManage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings\nProactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)\nOther:\nSupport CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.\nAssist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities\nPromote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations\nCollect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.\nKey Competencies:\nThis is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly\nThe individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders\nThe individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs\nMinimum Qualifications:\nBS/MS Degree in a scientific discipline, ideally life science or chemistry.\nAt least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).\n10+ years of Program Management experience, preferably in early-stage drug discovery and development.\nExperience in the development of advanced therapies to treat rare genetic disease is a plus\nDemonstrated experience leading cross-functional teams; strong interpersonal and communication skills\nScientific curiosity and passion for discovering new, innovative medicines.\nOpenness to embrace new technologies and digital approaches in drug discovery\nProven track record in driving successful, collaborative drug discovery teams.\nThe salary range for this role is $250,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.\nPrivacy Notice for Applicants: When you apply for a role at Alltrna, a Flagship Pioneering portfolio company, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact .","description_format":"text","description_chars":7662,"description_truncated":false,"requirements":{"experience_years_min":15,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Drug Discovery","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-13T23:21:32Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 2","filings_12m":2,"filings_prev_12m":2,"green_card_filings_12m":0,"median_offered_wage_usd":127500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":9,"band":"cold","label":"Long shot","p_open":1,"p_active":0.322,"p_room":0.28,"age_days":167,"expected_fill_days":28,"reasons":["conf:3","win:tail","crowd:"],"computed_at":"2026-10-21T05:46:15Z"},"pay":{"stated_usd_annual":330000,"is_top_pay":true},"html_url":"https://alion.io/job/alltrna-vp-program-management-business-operations","json_url":"https://alion.io/job/alltrna-vp-program-management-business-operations.json","meta":{"generated_at":"2026-10-21T15:32:25Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":22096,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":670770},"rest":"https://alion.io/mcp/rest/get_company?id=670770"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Falltrna-vp-program-management-business-operations"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Falltrna-vp-program-management-business-operations"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Falltrna-vp-program-management-business-operations"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/alltrna-vp-program-management-business-operations\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Falltrna-vp-program-management-business-operations"}]}