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Salary
$178k – $240k per year
Location
Hybrid (Cambridge, United States)
Seniority
Architect · 8+ years exp
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Confirmed on the employer's own hiring board on Oct 23, 2026. First seen by Alion on Oct 14, 2026.

Overview
Company
Impact
Profile match
Alnylam Pharmaceuticals is a biopharmaceutical company headquartered in Cambridge, Massachusetts, that develops and commercialises RNA interference therapeutics for rare and common diseases, including ATTR amyloidosis and acute hepatic porphyria. Founded in Cambridge in 2002 and listed on the Nasdaq, it has six approved medicines available in more than 70 countries, a manufacturing site in Norton, Massachusetts, a European base in Maidenhead and an affiliate in Tokyo. It hires research and biology scientists, quality control analysts, clinical science and regulatory affairs staff, field reimbursement and key account managers, and IT, cyber defense and HR technology leaders.

Associate Director, Program Management

                                                                  

Overview

 

At Alnylam, development-stage programs are managed by Program Leadership Teams, led by a Program Leader and a Program Manager, responsible for harnessing cross-functional expertise to define the best scientific, clinical, and commercial strategies and plans for the success of the Program. 

The role of the Associate Director, Program Management is to partner with Program Leaders to drive program strategy and execution of assets in Alnylam’s portfolio. The candidate will be responsible for providing a combination of drug development, stewardship, and program expertise to the Program Leadership Team. This role, through partnership with members of the Program Leadership Team, has significant responsibility for developing, driving, operationalizing, and executing the program strategy.  

The candidate will also be responsible for driving the identification/implementation of Program Management best practices within Alnylam.  In this capacity, the candidate will call upon prior experience and program management insights to continually help the Program Management team increase its efficiency and value.

This position is hybrid and will be primarily located in Cambridge, MA.

Key Responsibilities

 

  • Partner closely with Program Leader to shape and execute the Program strategy, goals and plans and ensure alignment within Program Team and across Expertise Areas.
  • Lead development and drive execution of Program integrated development plans,  risks and mitigations.
  • Drive coordination of cross-functional activities and promote effective communications (e.g., Team meetings, program updates) and integration of people involved with the program (e.g. clarity of responsibilities). For efficiency, this is done through coordination of critical, defined sub-teams.
  • In partnership with the Program Leader, ensure clear, timely, and substantive updates on Program progress and issues to Senior Leadership.
  • Manage Program Leadership Team meetings, including leading discussions to drive to decision-making, creating agendas, preparing meeting minutes and ensuring Program Team members have ready access to these materials.
  • Serve as a key point person for Program Team members and governance teams.
  • Align with finance on financial aspects of the Program, including liaising with collaboration partner, if applicable.
  • Provide expertise on program management initiatives including alignment of processes, tools, and technologies that aid in program management across the portfolio.

Qualifications

 

  • 8+ years total experience in pharmaceutical or biotechnology industry with in depth knowledge of the drug discovery, research, and development processes.
  • Direct clinical-stage drug development program management experience.
  • Strong leadership skills and ability to set team priorities, and drive results within a matrixed, collaborative, and dynamic team environment.
  • Excellent written and oral communication, including presentation and facilitation skills.
  • Strong analytical and problem-solving skills; ability to combine attention to detail within broader strategic context. 
  • Ability to thrive in a fast-paced environment with strong ability to simultaneously handle multiple activities, prioritizing and pivoting as necessary.
  • Passion for helping patients and developing transformative treatments for patients in need; motivated by patient focus and personal commitment to high performance and results. 
  • Bachelor’s degree required.

 #LI-AB1 #LI-Hybrid 

About Alnylam

We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's Candidate  Privacy Notice  regarding how Alnylam handles Personal Data you provide with your application for employment.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:  https://www.alnylam.com/careers

U.S. Pay Range

$177,500—$240,100 USD

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