{"id":3688603,"url":"https://alion.io/job/alnylam-director-epidemiology","title":"Director, Epidemiology","company":{"id":1776651,"name":"Alnylam","domain":"alnylam.com","url":"https://alion.io/company/alnylam","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":100,"open_postings":3,"ghost_share":0,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":30,"computed_at":"2026-11-05T05:54:30Z"}},"role":"Biotech","role_family":"Biotech","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":207100,"max":280100,"currency":"USD","period":"year","gross":null,"usd_annual":280100},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-11-03T14:54:03Z","employer_posted_date":"2026-11-03","last_verified_at":"2026-11-05T22:02:00Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"Director, Epidemiology\n\nOverview\nThe Director, Epidemiology is responsible for representing the Epidemiology function at Alnylam providing expertise, strategic vision, and oversight of epidemiology and real-world evidence (RWE) activities in support of all clinical development programs and marketed RNAi therapeutics. In this role, you will work closely with Clinical Research, Global Patient Safety and Risk Management (GPSRM, Regulatory Affairs, and Biostatistics, to inform clinical development and to answer product- and disease-area research questions for Alnylam RNAi therapeutics using observational studies and real-world evidence. The Director, Epidemiology sits within the Quantitative Sciences team and reports to the Senior Director and Head, Epidemiology. \n\nKey Responsibilities\nProvide a rigorous assessment of the incidence and prevalence of disease targets using literature reviews, database analysis, or extrapolation of estimates\nGuide and advise clinical development study teams on the design and collection of natural history data to better understand disease progression including risk factors and optimal endpoints for use in clinical trials\nUse real-world and clinical data to refine population size and characteristics for disease targets as clinical development progresses, in both rare disease and prevalent disease areas.\nPartner with Clinical Research and GPSRM to help interpret and refine potential safety signals during drug development.\nPartner with Biostatisticians and Statistical Programming to implement, provide technical oversight of analyses from natural history & other observational studies to support clinical development and the preparation of scientific publications, presentations and abstracts.\nProvide strategic and tactical expertise on the development of RWE for external comparators including advisement on the appropriate methodology for the use of RWE for regulatory purposes.\nSupport regulatory submission activities including authoring epidemiology sections of orphan or breakthrough designation applications and dossiers and provide scientific leadership on the design post-marketing commitment studies\nPartner with GPSRM to deliver and provide oversight for REMS, risk management plans and post-approval safety studies. Author epidemiology sections of DSURs and PRBERs. Investigate and understand potential safety signals for marketed RNAi therapeutics.\nEstablish real-world data partnerships in collaboration with Medical Affairs and Commercial and coordinate acquisition of real-world data to avoid duplication\nProvide leadership in the development of innovative RWE approaches, techniques, and standards to be used across teams\nMentor junior epidemiologists and RWE/observational analysts to ensure competence in epidemiologic skills and knowledge\nQualifications\nPhD in Epidemiology or other Quantitative Public Health discipline\nExperience applying epidemiologic methods in at least one disease area, preferably using pharmacoepidemiologic techniques\nOphthalmology experience highly preferred\nAbility to deliver complex epidemiological studies in a regulated environment with moderate supervision\nAt least 5 years of experience in the pharmaceutical industry or equivalent experience in an academic or government setting\nCurrent knowledge of emerging guidance from various regulatory authorities on the design of observational studies and the use of real-world data to support decision making.\nCurrent knowledge and expertise in emerging analytical methodologies, tools and applications to ensure fit-for-purpose and innovative approaches on the use of RWD to address pertinent questions.\nEffective communication skills both at the lay and technical level to inform stakeholders on the utility of RWE across the product lifecycle and drive use of study/analysis results to support internal and external decisions\nAbility to succeed in a matrixed environment with multiple stakeholders\nAbility to successfully manage priorities, resources, and performance targets\nKnowledge of private and public use datasets for the conduct of epidemiological studies\nBasic knowledge of regulatory requirements in the pharmaceutical industry\nProficient written and communication skills\n#LI-AB1 #LI-Virtual\nAbout Alnylam\nWe are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.\nAt Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.\nBefore applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.\nThe pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).\nAlnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.\nLearn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers\nU.S. Pay Range\n$207,100—$280,100 USD","description_format":"text","description_chars":6837,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Public Health & Prevention","Cell & Gene Therapy","Rare Disease Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-03T15:47:21Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 36 · green card filings: 9","filings_12m":36,"filings_prev_12m":48,"green_card_filings_12m":9,"median_offered_wage_usd":157500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":1,"expected_fill_days":30,"reasons":["conf:4","win:early"],"computed_at":"2026-11-05T05:54:30Z"},"pay":{"stated_usd_annual":280100,"is_top_pay":false},"html_url":"https://alion.io/job/alnylam-director-epidemiology","json_url":"https://alion.io/job/alnylam-director-epidemiology.json","meta":{"generated_at":"2026-11-06T02:15:13Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3658,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-07T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1776651},"rest":"https://alion.io/mcp/rest/get_company?id=1776651"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Falnylam-director-epidemiology"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Falnylam-director-epidemiology"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Falnylam-director-epidemiology"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/alnylam-director-epidemiology\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Falnylam-director-epidemiology"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3688603}},{"tool":"search_jobs","arguments":{"company":"alnylam.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3688603},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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