{"id":1258117,"url":"https://alion.io/job/alnylam-supervisor-manufacturing-first-shift","title":"Supervisor, Manufacturing - First Shift","company":{"id":1776651,"name":"Alnylam","domain":"alnylam.com","url":"https://alion.io/company/alnylam","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":100,"open_postings":3,"ghost_share":0,"stale_share":0,"repost_share":0.333,"time_to_fill_p50_days":21,"computed_at":"2026-10-27T05:46:45Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Norton, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":103500,"max":140100,"currency":"USD","period":"year","gross":null,"usd_annual":140100},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CAPA","optional":false},{"name":"GMP","optional":false},{"name":"LIMS","optional":false},{"name":"Microsoft Office","optional":false}],"status":"live","first_seen_at":"2026-09-14T14:08:11Z","employer_posted_date":"2026-10-15","last_verified_at":"2026-10-27T10:07:54Z","board_verified":true,"closed_at":null,"days_open":42,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":42},"description":"Overview\nThe Supervisor, Manufacturing is an integral part of the Norton Internal Manufacturing team. This role will initially be involved in the start-up of Norton’s new commercial Drug Substance manufacturing train, including support for equipment commissioning & qualification, generation of GMP documentation, and successful execution of Drug Substance engineering and PPQ batches all the way through commercial production and launch. The Supervisor is responsible for hiring and managing manufacturing technicians to support the start-up activities and successful execution of manufacturing campaigns. \nThis position is a first-shift on-site role in Norton, MA that will report to the Manufacturing Sr. Manager. The role is executed primarily on the floor inside the manufacturing suite.\nKey Responsibilities\nDay-to-Day People ManagementLead, coach, and develop a team of technicians to ensure safe, compliant, and efficient operations.\nRecruit, hire, onboard, and train new team members.\nFoster a positive, safety-focused culture aligned with Alnylam's values and leadership principles.\nSet clear goals and expectations, provide regular feedback, and support employee development.\nConduct routine 1:1s, performance reviews, and training assessments to drive engagement and performance.\nProvide floor leadership, balancing operational priorities, project work, and team development.\nAddress employee relations and performance issues in partnership with Human Resources as needed.\nBuild a high-performing team focused on quality, continuous improvement, and operational excellence.\n\nCommercial Train Start-UpSupport for new equipment commissioning & qualification testing, including attending Factory Acceptance Tests (FAT’s), reviewing/approving protocols as the end user subject matter expert, and assisting on-the-floor protocol execution\nCreation and approval of GMP documentation, including SOP’s and batch records\nAssisting with planning and directing an efficient layout of equipment and flow of materials\nAssisting with design and implementation of electronic logbooks, batch records, and workflows within a new Manufacturing Execution System\n\nIndependent Resolution of Complex ProblemsMonitor process and troubleshoot upset conditions that may arise (equipment issues, opening deviations, inability to follow SOP, etc.)\nThorough understanding of GMP Standards, leading by example and escalating problems through the quality and manufacturing organization as needed\nTechnical process experience assessing equipment output to ensure it meets process expectations Independently assess situations and respond with appropriate sense of urgency to issues as they occur\nGain a thorough understanding of equipment operation and process automation systems\n\nEnsure smooth operation of production activitiesEvaluate production plans and proactively assess upcoming processes (including materials needed vs. current inventory, planned operator time off, conflicting priorities, etc.) to identify and resolve issues in advance\nEnsure trained operators are available for all operations and determine where backup support may be needed\nReview schedule for feasibility and work closely with Manufacturing Scheduler to resolve scheduling conflicts\nGeneral oversight of operation readiness\nDevelop continuous improvement mindset through KPI’s and best practices, eg regular Gemba Walks\nParticipates in KPI generation, reporting and countermeasures involving schedule adherence, right-first-time documentation, deviation reduction, training compliance, safety performance, throughput, and continuous improvement outcomes\nInterfaces with MTS, Engineering, Maintenance, Automation, Supply Chain, Warehouse, QC, EHS, Validation, and Scheduling\nDrives daily performance through Tier Management to ensure Safety, Quality, Delivery, Cost, and People are in line with site KPIs\nFosters Collaboration and Accountability to ensure that Action Items are owned, and resolved on time\n\nQuality and ComplianceRole model GMP compliance for team\nPerform batch record reviews as needed and support team with errors or corrections to limit document revisions\nDrive excellence through document reviews\nInterface with Quality Assurance and other support groups to ensure operators can focus on execution\nMaintain inspection-ready areas, supporting audits/regulatory inspections, and coaching technicians on inspection behaviors.\nSupport/lead deviation investigations, root cause analysis, CAPA execution, change controls, or audit inspection support\nAccountable for EHS compliance, safe work permits, PPE, safety observations, incident escalation, and investigation support\nIndividual possesses a Quality by Design Mindset striving toward Right First Time Standard of Excellence\nPerforms real time review of documentation to ensure GMP quality and drive optimum batch turnaround time\n\nOther duties as assigned\n Qualifications\nPreferred education background of BA/BS in science, engineering, or related discipline\nFive (5) or more years experience in a biotech/pharmaceutical GMP manufacturing role\nTwo (2) or more years experience leading teams in a GMP environment, coaching hourly/non-exempt staff, managing performance, and supporting shift operations\nKnowledge of GMP regulations (CFR, Eudralex, ICH, etc)\nIn-depth understanding of commercial GMP manufacturing, continuous improvement, and cGMP regulations.\nProven ability to work independently, leadership aptitude, and good people skills with the desire and ability to work in a fast-paced, start-up environment\nStrong collaboration and team-building, communication, and organizational skills required\nProficiency with Microsoft Office applications\nProficiency with process automation software, SAP, LIMS, electronic document management system\nPrior experience with MES/eBR execution and design strongly preferred\nAbility to support shift hours including days, nights, weekends, rotating shifts, on-call coverage, or campaign-based extended hours.\nAbout Alnylam\nWe are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.\nAt Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.\nBefore applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.\nThe pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).\nAlnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.\nLearn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers\nU.S. Pay Range\n$103,500—$140,100 USD","description_format":"text","description_chars":8565,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Rare Disease Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-25T19:36:08Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 36 · green card filings: 9","filings_12m":36,"filings_prev_12m":48,"green_card_filings_12m":9,"median_offered_wage_usd":157500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":17,"band":"cold","label":"Long shot","p_open":1,"p_active":0.614,"p_room":0.28,"age_days":42,"expected_fill_days":21,"reasons":["conf:0","win:tail","crowd:brand"],"computed_at":"2026-10-27T05:46:45Z"},"pay":{"stated_usd_annual":140100,"is_top_pay":true},"html_url":"https://alion.io/job/alnylam-supervisor-manufacturing-first-shift","json_url":"https://alion.io/job/alnylam-supervisor-manufacturing-first-shift.json","meta":{"generated_at":"2026-10-27T12:35:35Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":316,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-28T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1776651},"rest":"https://alion.io/mcp/rest/get_company?id=1776651"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Falnylam-supervisor-manufacturing-first-shift"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Falnylam-supervisor-manufacturing-first-shift"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Falnylam-supervisor-manufacturing-first-shift"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/alnylam-supervisor-manufacturing-first-shift\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Falnylam-supervisor-manufacturing-first-shift"}]}