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Salary
$120k – $170k per year
Location
In office (Aliso Viejo)
Seniority
Middle · 5+ years exp
Employment
Full-Time

Confirmed on the employer's own hiring board on Sep 24, 2026. First seen by Alion on Sep 11, 2026.

Overview
Company
Impact
Profile match
Ambry Genetics is a company built by scientists, genetic counselors and physicians, dedicated to leading the clinical genomic diagnostic industry. Ambry boasts the largest genetic sequencing lab in the world; is CAP-accredited, CLIA-licensed and, as part of the Konica Minolta family, has access to the most complete suite of diagnostic technology in the world. Ambry Genetics' scope of clients includes some of the world's most respected academic institutions, pharmaceutical companies and leading treatment hospitals.

Compensation:

$120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

  • Provide structural biology support for variant analyses through structure-function relationship interpretation.

  • Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.

  • Partner with statisticians and data scientists to validate algorithms and data collection workflows.

  • Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.

  • Write testable, production-grade code adhering to SDLC standards and code review best practices.

  • Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.

  • Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion

  • Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

  • Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.

  • Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.

  • Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

PRIVACY NOTICES

To review Ambry’s Privacy Notice, Click here: https://www.ambrygen.com/legal/privacy-policy

To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics

To review the UKG privacy notice, click here: California Privacy Notice | UKG

Equal Opportunity Employer

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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