{"id":597997,"url":"https://alion.io/job/amgen-senior-engineer-mathematical-modeling-and-simulation","title":"Senior Engineer: Mathematical Modeling and Simulation","company":{"id":4775,"name":"Amgen","domain":"amgen.com","url":"https://alion.io/company/amgen","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":83,"open_postings":334,"ghost_share":0,"stale_share":0.668,"repost_share":0.015,"time_to_fill_p50_days":43,"computed_at":"2026-11-09T06:03:00Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":115494,"max":156257,"currency":"USD","period":"year","gross":null,"usd_annual":156257},"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Abaqus","optional":true},{"name":"ANSYS","optional":true},{"name":"Design Controls","optional":true},{"name":"MATLAB","optional":true},{"name":"Python","optional":true}],"status":"live","first_seen_at":"2026-09-10T17:16:14Z","employer_posted_date":"2026-09-10","last_verified_at":"2026-11-09T05:14:05Z","board_verified":true,"closed_at":null,"days_open":59,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":59},"description":"Career Category\nEngineeringJob Description\nJoin Amgen’s Mission of Serving Patients\nAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.\nSince 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.\nOur award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.\nSenior Engineer Mathematical Modeling and Simulation\nWhat you will do\nLet’s do this. Let’s change the world. Amgen's Combination Product Operations Digital and Data Strategies group is a process development team that develops and deploys innovative advanced simulation technologies towards improved process understanding, robustness and monitoring, and prediction and optimization of the manufacturing of combination products.\nIn this vital role you will support the team by incorporating physics and empirical techniques to develop rigorous finite element models (FEM) and numerical models of drug delivery devices (in-silico modeling assets) and improving the way Amgen manages and uses in-silico models to enhance decision making within the organization.\nThe candidate will apply engineering principles to develop efficient and trustworthy models addressing a wide variety of challenging problems associated with advanced material modelling, device design, characterization, verification, validation, manufacturing and tolerance analysis.\nThe ideal candidate enjoys tackling challenges and excels at developing functional in-silico models of combination products that enable insights for root cause investigation and design robustness supporting lifecycle management activities and complaint reduction.\nResponsibilities:\nImplementing explicit and implicit FEM structural models. Ensuring that the approach and simplifications used to build these models is efficiently representing the physical system.\nApplying engineering principles like kinematic, structural, and tolerance analysis combined with material characterization and testing to create in-silico models able to capture the behavior of the device during use, assembly and transport.\nContinuous improvement of in-silico models, managing the lifecycle of the model and improving methods and workstreams to guarantee efficiency and trustworthiness of the models.\nDemonstrating critical and analytical thinking skills to explore new opportunities in in-silico and data-driven computational models. Modeling real-world scenarios with the adequate level of detail and help inform the decision making in a reduced time frame.\nSimulate complaints and real-world issues within lifecycle of combination products. Being able to apply an analytical approach to create models that accurately represent the real world scenarios and helps identify the root cause analysis of any complaint.\nProviding positive leadership and delivering work in a fast-paced, multi-project, cross-functional environment. Delivering predictions and insight on time to solve challenging production and customer problems..\nModel ownership, responsible for developing and managing backlog of in-silico product projects. Being able to concisely communicate on the modelling scope, limitations and assumptions to stakeholders with a technical and not technical background. Mentor also other simulation experts in the best use of simulation technologies.\nIt is expected that the Senior Engineer - Modeling and Simulation will not only lead and collaborate heavily with internal team members, but also document and communicate the underlying technical basis of the models for the benefit of and use by the broader engineering and scientific community responsible for design and manufacture of drug delivery devices.\nWhat we expect of you\nWe are all different, yet we all use our unique contributions to serve patients. The Engineer professional we seek is an individual with these qualifications.\nBasic Qualifications:\nDoctorate degree\nOR\nMaster’s degree and 2 years of Engineering experience\nOR\nBachelor’s degree and 4 years of Engineering experience\nOR\nAssociate’s degree and 8 years of Engineering experience\nOr\nHigh school diploma / GED and 10 years of Engineering experience\nPreferred Qualifications:\nFinite element model experience with a commercial platform like SIMULIA, ANSYS, ALTAIR or COMSOL.\nExperience in explicit FEM modelling and non-linear structural models; contact modelling, large deformations, plasticity, and hyperelasticity.\nKnowledge of statistic and robustness analysis principles, being able to create models capturing the inherent variability in the process and device dimensions.\nSkilled in programming in Python, and/or MATLAB for engineering purposes. Scripting using commercial software codes like abaqus user subroutines, Tcl/Tk to automate model creation and post/processing.\nExperience with combination products and device regulatory requirements, medical device development and design controls, and knowledge of process controls.\nExcellent communication, presentation, and technical documentation skills are highly desired.\nIntellectual curiosity with ability to learn new concepts/frameworks, algorithms, and technology rapidly as needs arise.\nAbility to manage multiple competing priorities simultaneously and work in highly collaborative, cross-functional environments.\nWhat you can expect of us\nAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.\nThe expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.\nIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:\nA comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts\nA discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan\nStock-based long-term incentives\nAward-winning time-off plans\nFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.\nApply now and make a lasting impact with the Amgen team.\ncareers.amgen.com\nIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.\nAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.\nSponsorship\nSponsorship for this role is not guaranteed.\nAs an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.\nAmgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.\nWe will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.\n.Salary Range\n115,494.60USD -156,257.40 USD","description_format":"text","description_chars":8902,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"high_school","optional":true},"security_clearance":false,"languages":[]},"benefits":["Flexible schedule","Retirement plans"],"hiring_locations":[],"hiring_excludes":[{"name":"Puerto Rico","iso":"PR"}],"relocation_offered":false,"industries":["Prescription Drugs","Biologics & Biosimilars","Immunology & Inflammation Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-10T17:16:14Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 372 · green card filings: 113","filings_12m":372,"filings_prev_12m":465,"green_card_filings_12m":113,"median_offered_wage_usd":136675,"route":null,"cap_exempt":false,"checked_at":"2026-11-09T07:32:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":25,"band":"fade","label":"Fading","p_open":1,"p_active":0.567,"p_room":0.44,"age_days":59,"expected_fill_days":43,"reasons":["conf:0","stale_co","velocity","win:tail","crowd:brand"],"computed_at":"2026-11-09T06:03:00Z"},"pay":{"stated_usd_annual":156257,"is_top_pay":true},"html_url":"https://alion.io/job/amgen-senior-engineer-mathematical-modeling-and-simulation","json_url":"https://alion.io/job/amgen-senior-engineer-mathematical-modeling-and-simulation.json","meta":{"generated_at":"2026-11-09T10:44:12Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11781,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-10T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4775},"rest":"https://alion.io/mcp/rest/get_company?id=4775"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Famgen-senior-engineer-mathematical-modeling-and-simulation"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Famgen-senior-engineer-mathematical-modeling-and-simulation"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Famgen-senior-engineer-mathematical-modeling-and-simulation"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/amgen-senior-engineer-mathematical-modeling-and-simulation\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Famgen-senior-engineer-mathematical-modeling-and-simulation"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":597997}},{"tool":"search_jobs","arguments":{"company":"amgen.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":597997},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}