{"id":3343690,"url":"https://alion.io/job/amgen-senior-systems-engineer","title":"Senior Systems Engineer","company":{"id":4775,"name":"Amgen","domain":"amgen.com","url":"https://alion.io/company/amgen","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":86,"open_postings":358,"ghost_share":0,"stale_share":0.575,"repost_share":0.006,"time_to_fill_p50_days":42,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"senior","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":120000,"max_usd":227000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":6333},"experience_years_min":6,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Design Controls","optional":false},{"name":"Verification & Validation","optional":false}],"status":"live","first_seen_at":"2026-10-27T16:30:35Z","employer_posted_date":"2026-10-27","last_verified_at":"2026-10-30T04:15:22Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"Career Category\nEngineeringJob Description\nJoin Amgen’s Mission of Serving Patients\nAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.\nSince 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease, obesity and obesity-related conditions, rare diseases, inflammatory conditions and cancer. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.\nOur award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.\nSenior Systems Engineer\nWhat you will do\nLet’s do this! Let’s change the world! The Senior Systems Engineer leads development activities within a cross-functional program team to create the technical content, performance, intellectual property and quality deliverables of a combination product (device/biologic combination) development program.\nThis role leads the capture of user needs and translation into system requirements and is also responsible for the functional decomposition and allocation to subsystems. The Senior Systems Engineer owns respective systems engineering deliverables and ensures that the quality targets are satisfied, identifies and communicates technical risks and coordinates risk retirement activities on the program. Also, maintains close cross-functional interaction within Amgen to deliver on customer satisfaction through high product quality.\nThis AMA-based role requires regular collaboration during East Coast business hours and partners across engineering, quality, regulatory, supply chain, packaging, labeling, and product teams to ensure lifecycle changes are assessed, documented, and implemented in a controlled manner.\nLead systems engineering assessment, planning, and cross-functional coordination of lifecycle change controls.\nPerform system-level impact assessments for proposed changes, including impacts to requirements, design documentation, risk management, traceability, verification evidence, and combination product configurations.\nMaintain system requirements, specifications, and traceability as released systems evolve.\nDetermine and coordinate re-verification or additional verification when lifecycle changes could affect the verified state.\nMaintain systems engineering-owned design control documentation, including requirements, traceability, verification plans and reports, risk inputs, and change assessments.\nSupport supplier-, packaging-, labeling-, manufacturing-, and subsystem-driven changes that affect the combination product system.\nLead systems engineering evaluation and implementation planning for new or revised standards and regulatory requirements.\nSupport design transfer activities and implementation of approved lifecycle changes.\nDrive continuous improvement in lifecycle management processes, requirements practices, verification approaches, and reuse of engineering evidence.\nCommunicate technical assessments, recommendations, risks, and implementation status to cross-functional stakeholders and leadership.\nLead requirements development and maintenance activities, including alignment of user needs, design inputs, design outputs, and verification and validation planning.\nReview and approve completed design documentation.\nDrive systems engineering input to design reviews and facilitate cross-functional resolution of system-level technical issues.\nMentor Junior engineers.\nWhat we expect of you\nWe are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.\nBasic Qualifications:\nDoctorate degree \nOR\nMaster’s degree and 2 years of experience\nOR\nBachelor’s degree and 4 years of experience \nOR\nAssociate’s degree and 8 years of experience \nOR \nHigh school diploma / GED and 10 years of experience\nPreferred Qualifications:\n6+ years of progressive experience as an engineer within the appropriate field of study.\n5+ years of experience in product development working with mechanical medical devices, ideally combination products (device/biologics combination).\nFormal Systems Engineering training/certification.\nDemonstrated applied lean 6 Sigma competency.\nCreative problem solver and solution developer when presented with conflicting requirements, business demands and technical risks/issues.\nDemonstrated experience in systems engineering, product development, medical devices, or combination products.\nStrong lifecycle management and change-control experience in a regulated environment.\nStrong understanding of design controls, requirements management, traceability, risk management, and design verification.\nExperience conducting technically rigorous system-level impact assessments and defining verification needs for product changes.\nAbility to lead assessment of new and revised standards and regulatory requirements and translate them into actionable engineering plans.\nProven cross-functional coordination and influence skills across technical, quality, regulatory, and operational functions.\nExcellent written and verbal communication skills, including the ability to clearly document technical rationale and present complex information to diverse stakeholders.\nExperience translating stakeholder and user needs into clear, testable system requirements and maintaining end-to-end traceability.\nWorking knowledge of system integration, interface management, design reviews, and verification and validation planning.\nAbility to lead technical discussions, evaluate tradeoffs, and resolve cross-functional system-level issues.\nWhat you can expect from us\nAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.\nThe expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.\nIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:\nA comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts\nA discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan\nStock-based long-term incentives\nAward-winning time-off plans\nFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.\nApply now and make a lasting impact with the Amgen team.\ncareers.amgen.com\nIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.\nApplication deadline\nAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.\nSponsorship\nSponsorship for this role is not guaranteed.\nAs an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.\nAmgen is an Equal Opportunity employer. We make all employment decisions without regard to race, color, religion, sex or any other characteristic protected by applicable law.\nWe provide reasonable accommodations to applicants and employees with disabilities, consistent with legal requirements. Please contact us to request accommodation.\n.Salary Range\n115,494.60USD -156,257.40 USD","description_format":"text","description_chars":8626,"description_truncated":false,"requirements":{"experience_years_min":6,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"high_school","optional":false},"security_clearance":false,"languages":[]},"benefits":["Flexible schedule","Retirement plans"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[{"name":"Puerto Rico","iso":"PR"}],"relocation_offered":false,"industries":["Prescription Drugs","Biologics & Biosimilars","Immunology & Inflammation Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-27T16:30:35Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 372 · green card filings: 113","filings_12m":372,"filings_prev_12m":465,"green_card_filings_12m":113,"median_offered_wage_usd":136675,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":1,"age_days":2,"expected_fill_days":42,"reasons":["conf:1","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-10-30T05:48:23Z"},"pay":null,"html_url":"https://alion.io/job/amgen-senior-systems-engineer","json_url":"https://alion.io/job/amgen-senior-systems-engineer.json","meta":{"generated_at":"2026-10-30T09:03:36Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12955,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4775},"rest":"https://alion.io/mcp/rest/get_company?id=4775"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Famgen-senior-systems-engineer"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Famgen-senior-systems-engineer"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Famgen-senior-systems-engineer"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/amgen-senior-systems-engineer\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Famgen-senior-systems-engineer"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3343690}},{"tool":"search_jobs","arguments":{"company":"amgen.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3343690},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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