{"id":3875404,"url":"https://alion.io/job/astrazeneca-associate-director-principal-engineer-2","title":"Associate Director Principal Engineer","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":93,"open_postings":167,"ghost_share":0.012,"stale_share":0.383,"repost_share":0.108,"time_to_fill_p50_days":19,"computed_at":"2026-11-08T05:47:12Z"}},"role":"Leadership","role_family":"Leadership","seniority":"head","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Mount Vernon, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GMP","optional":false},{"name":"ITIL","optional":false},{"name":"Statistical Process Control","optional":false}],"status":"live","first_seen_at":"2026-11-04T00:00:00Z","employer_posted_date":"2026-11-04","last_verified_at":"2026-11-08T18:53:20Z","board_verified":true,"closed_at":null,"days_open":4,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":4},"description":"The Associate Director Principal Engineer is responsible providing technical support for process manufacturing, including investigation and correction of process-related problems and deviations from standards. Serves as a Subject Matter Expert for multiple processing operations and provides technical leadership within the Process Engineering team. May lead and manage Technology Transfers to and from the site.\nResponsibilities\nProvides technical support for formulation areas, including investigation and correction of process related problems and deviations from standards.\nResponsible for identifying and executing projects to reduce product cost, improve product quality, improve yield, and reduce material usage.\nCollaborates with Production, Engineering, Automation, and Quality to optimize productivity, yield, product quality, and supply reliability.\nAssists in designs and execution of process qualifications and validations for approved changes.\nInitiates process manufacturing area change proposals as required for projects managed by the Formulation or Process Engineering group.\nAuthors, updates, reviews, and approves area procedures to ensure correct content and compliance with Good Manufacturing Practices.\nAuthors, reviews, and approves formulation master batch records.\nServes as a subject matter expert for technical projects affecting formulation during internal audits and regulatory inspections.\nLeads technology transfer and implementation of new technologies, equipment, and processes from R&D and other sites, to the Mount Vernon site.\nEnhances quality and effectiveness of manufacturing systems related to existing products as the Product Owner. This includes the design, execution, and evaluation of experimental plans to ascertain the required process capabilities, specifications, and robustness.\nExecutes site PAT strategy to monitor and control existing manufacturing processes.\nResponsible for providing pharmaceutical process support to new and existing oral solid dose form (tablet and capsule) products/processes.\nTrains and mentors new Process Engineers and interns. •Develops Product/Process knowledge in multiple product streams and technologies.\nLeads product scale up activities related to volume increases and/or product demand.\nResponsible for Technology Transfer for new solid oral dosage form (tablet and capsule) products being transferred to the site as required.\nDesigns and executes Process Validation Studies supporting the commercialization of the TT products.\nIdentifies, recommends, and implements equipment modifications to ensure improved/optimized process performance.\nContributes to Equipment URS development and retrofit. Participates in Equipment FATs, SATs, etc.\nJustifies processing parameters and conducts scale-up activities.\nIntroduces new manufacturing processes, technologies (including Process Analytical Technologies), and systems including the definition of equipment and facilities needed.\nExecutes the transfer and startup of new products/processes through plant trial runs and or clinical/pivotal stability lots, guaranteeing implementation of a robust and efficient process. Provides technical support for process manufacturing areas, including investigation and correction of manufacturing technical/quality issues that could potentially lead to a disruption in product supply.\nCollaborates with Production, Engineering, Automation, and Quality to optimize productivity, yield, product quality, and supply reliability.\nConducts statistical process control and process capability analyses for TT projects and existing products.\nInvestigates and conducts troubleshooting and root-cause analysis of unexpected trends or results related to product quality and financial aspects due to material and/or process related factors during the execution of TT or routine production.\nIdentifies best practices in industry related to technology transfers and pharmaceutical manufacturing technologies; implements effective best practices to create a competitive advantage for the site.\nAccountabilities\nConduct activities and interactions consistent with Company values and in compliance with the Code of Ethics and supporting Policies and Standards relevant to your role. Complete all required training on the AZ Code of Ethics and supporting Policies and Standards on time. Report potential issues of non-compliance.\nEnsures compliance with AZ Corporate Policies and Directives, site Standard Operating Procedures, site policies, work instructions, regulatory requirements, and industry best practice (cGMPs, GAMP, ITIL, PMI).\nMaintains a safe work environment and performs work in accordance with site, Safety, Health, and Environment (SHE) policies and procedures.\nImmediately report potential unsafe conditions to management.\nSupports internal, external, and regulatory inspections including FDA, EMEA, and third party inspections.\nParticipates in the investigation and resolution of product quality problems.\nExecutes work in compliance with cGMPs, site policies, work instructions, and SOPs.\nEssential Requirements\nBachelor’s degree required, preferably in Science, Chemical Engineering, or other related technical discipline.\nMinimum of 10 years’ experience in pharmaceutical production, process engineering, project engineering, or project management. Experience in the OSD pharmaceutical industry required.\nStrong understanding of cGMPs; demonstrated leadership, management, and technical capabilities. •Thorough knowledge of product and process development, manufacturing scale-up, continuous process improvement, and troubleshooting tools and analysis.\nExcellent verbal, written, and interpersonal communication skills are essential. •Must have demonstrated ability to effectively manage multiple major projects at the same time with minimum supervision.\nMust have a proven ability to influence\nDesired Requirements\nMaster’s degree and/or PhD is highly desirable.\nExperience with IQ/OQ/PQ and Lean Manufacturing is highly desirable. Six Sigma certification is preferred.\nProven experience with Statistical Process Control, Process Capability Analysis.\nDate Posted\n04-Nov-2026Closing Date\n10-Nov-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.","description_format":"text","description_chars":6589,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Oncology Therapeutics","Rare Disease Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-06T16:07:20Z"}],"visa":[],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":4,"expected_fill_days":19,"reasons":["conf:2","velocity","win:early","comp:brand"],"computed_at":"2026-11-08T05:47:12Z"},"pay":null,"html_url":"https://alion.io/job/astrazeneca-associate-director-principal-engineer-2","json_url":"https://alion.io/job/astrazeneca-associate-director-principal-engineer-2.json","meta":{"generated_at":"2026-11-08T21:46:58Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":45471,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-09T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":13195},"rest":"https://alion.io/mcp/rest/get_company?id=13195"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fastrazeneca-associate-director-principal-engineer-2"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fastrazeneca-associate-director-principal-engineer-2"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fastrazeneca-associate-director-principal-engineer-2"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/astrazeneca-associate-director-principal-engineer-2\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fastrazeneca-associate-director-principal-engineer-2"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3875404}},{"tool":"search_jobs","arguments":{"company":"astrazeneca.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3875404},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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