{"id":3817024,"url":"https://alion.io/job/astrazeneca-associate-principal-ai-engineer-mathematical-optimisation","title":"Associate Principal AI Engineer - Mathematical Optimisation","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":93,"open_postings":165,"ghost_share":0.006,"stale_share":0.388,"repost_share":0.103,"time_to_fill_p50_days":19,"computed_at":"2026-11-05T05:54:30Z"}},"role":"AI/ML","role_family":"AI/ML","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Cambridge, United Kingdom"],"countries":["GB"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CI/CD","optional":false},{"name":"LLM","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-11-05T16:28:20Z","employer_posted_date":"2026-11-05","last_verified_at":"2026-11-06T03:33:39Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"Role: Associate Principal AI Engineer - Mathematical Optimisation\nLocation: Cambridge UK\nSalary: Competitive + Excellent Benefits\nDo you have expertise in, and passion for Operations Research and AI? Would you like to apply your modelling expertise in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the place for you!\nDisrupt an industry and change lives\nAt AstraZeneca, we are committed to being a great place to work, where people are empowered to push the boundaries of science and make a meaningful impact on patients, medicine, and society. We foster an inclusive culture built on diversity, collaboration, and continuous learning.\nIn technology, you will be encouraged to take ownership, challenge the status quo, and drive innovation. By enabling the business to operate faster and more effectively, you will help deliver solutions that ultimately improve lives around the world.\nWhat you’ll do\nThe ideal candidate will bring proven experience in designing, developing, and supporting end-to-end AI and optimisation solutions across a broad range of business challenges.\nThis role offers the opportunity to work on some of the most complex and high-impact AI and optimisation engineering problems in the pharmaceutical industry. As part of a global team of AI engineers, data scientists, scientists, and software developers, you will help design, build, and support tools that transform how AstraZeneca operates at scale, improving efficiency in our mission to benefit millions of patients worldwide.\nYou will work closely with engineering and product teams to deliver and support scalable solutions within the AstraZeneca technology landscape, while championing software engineering best practices across the organisation.\nWe are looking for an engineer who can build and maintain robust, accurate, and reliable end-to-end AI solutions used across AstraZeneca. You should be comfortable working with complex systems and applying AI and optimisation at scale to drive productivity and business impact.\nKey Accountabilities\nContribute to design and development of end-to-end AI solutions that include mathematical optimisation, modelling, and simulation approaches.\nVisualise complex datasets and model outputs using the latest front-end technologies.\nWork together with senior optimisation engineers and AI engineers in the team, focused on product delivery and support.\nLiaise with other engineers to enhance our technological stack, to enable the adoption of the latest advances in AI and software engineering.\nContribute to various solutions and applications that may cover a broad range of business areas, sometimes at once.\nBe self-driven, curious, innovative, deeply technical and learn continuously.\nEssential for the role\nExperience and demonstrable technical skills in developing operations research solutions for complex real-world problems.\nDemonstrated experience using mathematical optimisation software such as CPLEX, Gurobi, SCIP, or OR-Tools.\nExperience with heuristic and meta-heuristic algorithms as an alternative to the above software.\nA working knowledge of optimisation, simulation, and statistical concepts.\nA working knowledge of LLM tools.\nExperience in good software development practice, ideally including Python, and deployment practices such as CI/CD, testing, version control.\nA track record of understanding and translating complex business challenges into well-defined engineering problems.\nCreative, collaborative, & product focused.\nMSc or above.\nDesirable for the role\nExperience of adjacent topics such as control and robotics.\nExperience in the deployment of AI tools.\nExperience in developing and deploying interactive applications (e.g., full-stack apps, dashboarding).\nSo, what’s next?\nBe part of something where your work directly impacts a big purpose: to develop life-changing medicines. Join Us!\nWhere can I find out more?\nOur Social Media,\nFollow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/\nFollow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/\nFollow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en\nWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.\nDate Posted\n05-Nov-2026Closing Date\n20-Nov-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. 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