{"id":1968958,"url":"https://alion.io/job/astrazeneca-associate-principal-scientist-formulation-and-process-design","title":"Associate Principal Scientist - Formulation and Process Design","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":91,"open_postings":124,"ghost_share":0,"stale_share":0.508,"repost_share":0.056,"time_to_fill_p50_days":20,"computed_at":"2026-10-23T05:54:15Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Durham, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":138000,"max":207000,"currency":"USD","period":"year","gross":null,"usd_annual":207000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Digital Twin","optional":false}],"status":"closed","first_seen_at":"2026-10-06T18:27:22Z","employer_posted_date":"2026-10-06","last_verified_at":"2026-10-23T12:34:02Z","board_verified":false,"closed_at":"2026-10-23T12:34:02Z","days_open":16,"trust":{"level":"not_scored","repost_count":null,"flags":[],"days_open":16},"description":"About AstraZeneca:\nAstraZeneca is a global, science-led biopharmaceutical company and our innovative medicines are used by millions of patients worldwide. This is the place to make an impact. Here we ensure everyone can reach their full potential, perform at their best and make a valued contribution to the enterprise!\nAbout Pharmaceutical Technology & Development (PT&D) and Global Product Development (GPD):\nPT&D is the bridge that turns brilliant science into real medicines, spanning the entire value chain-from early toxicology and clinical supplies to technology that enables robust commercial manufacture. Within PT&D, GPD leads the late-stage design and development of drug products across a range of dosage forms. We develop the formulation, manufacturing process, and scientific understanding needed to scale, launch, and sustain new medicines. You’ll collaborate in highly multidisciplinary teams with engineers and pharmaceutical scientists to advance life-changing medicines for patients.\nThe Opportunity:\nWe are seeking an Associate Principal Scientist within Formulation and Process Design, that can balance formulation development and process engineering with a passion for application of digital tools with experience in solid dosage product development (tablets, capsules).\nIn this role you will work closely with a team of colleagues in a multi-disciplinary environment to assess, design, develop and deliver high quality clinical and commercial formulations and processes. You can expect to contribute to programs at laboratory scale with line of sight for commercial manufacture by using modelling and simulation approaches as first intent combined with hands-on experimental work as needed. You will play a key role in leading the formulation aspects of projects in late-stage development spanning an exciting portfolio of oral solid dosage forms (including Continuous Direct Compression). You will be an important member of a multidisciplinary team, providing input to the overall product development, designing and executing lab based and pilot plant work packages and driving the development and implementation of in silico tools to support and accelerate development.\nYou will be a recognized problem solver and team player who thrives under pressure and has a passion for ensuring product robustness through the development of manufacturing processes which are well understood, controlled, and capable of meeting long-term commercial and patient needs.\nKey Responsibilities:\nLead formulation input for the design and development of robust oral solid dosage forms.\nLab-based formulation and process development: plan and execute lab-scale experiments to facilitate project decisions.\nShape the scientific and technical direction of product development activities through formulation understanding and process design and control.\nHelp define and optimize critical process parameters (CPPs) and integrate them into control strategies.\nLead or contribute to technology transfer, risk assessment, process validation and scale-up.\nApply modelling, simulation, digital twins and predictive tools to enhance process understanding.\nSolve key technical challenges with direct impact on current project delivery.\nDrive a culture of creativity, innovation and scientific excellence.\nCross-functional collaboration: Contribute to integrated drug product development plans within a multidisciplinary team.\nWork hands-on to generate data as well as work collaboratively with other experimentalists with different backgrounds to identify/use/drive digital applications as first intent to strategically direct experimentation.\nBe part of cross-functional project teams focusing on developing drug products ranging from both early to late-stage development.\nBe a key player to drive and further develop the digital transformation within Formulation & Process Design (FPD).\nEstablish strong working relationships with the Modelling & Simulation team members and with other colleagues in Global Product Development to enable an impact-driven application of modelling and simulation tools.\nManage your own work to achieve drug development and improvement project targets, in a timely fashion, and to agreed quality standards, by applyingtechnical knowledge and expertise as well as interpreting results and adapting investigations as appropriate.\nParticipate in scientific and/or technology networks to increase base-line knowledge and create awareness of new developments in relevant areas\nEssential Skills and Experience:\nBachelor’s degree in Related Discipline (e.g - Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences) with 5 - 10 years of relevant industrial experience.\nExperience in oral solid dose development.\nExperience in late-stage product development, technology transfer, scale-up and process validation.\nStrong interest in applying modelling and simulation to deliver value in transferring projects from early to late phase development of pharmaceutical drug products. \nFundamental understanding of control strategy and risk management.\nBasic understanding of predictive science, artificial intelligence, modelling and simulation.\nA rational approach to problem solving, and an ability to make judgements based on sound reasoning.\nOperates confidently and collaboratively within a global organization, with an integrating mind-set\nDesirable Skills and Experience:\nMasters or PhD in Life Sciences (e.g. - Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences).\nExperience formulating/Drug Product development for a range of oral solid dosage units and operations e.g. continuous manufacturing, granulation, compression, coating.\nExperience of applying modelling and simulation tools \nExperience with regulatory authoring and defense.\nExperience with CMOs/CROs and outsourced development.\nThe annual base pay for this position ranges from$138 K to $207K. Our positions offer eligibility for multiple incentives an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.\nDate Posted\n06-Oct-2026Closing Date\n22-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.","description_format":"text","description_chars":6769,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Oncology Therapeutics","Rare Disease Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-06T18:27:22Z"},{"event":"close","at":"2026-10-23T12:34:02Z"}],"visa":[],"liveness":null,"pay":{"stated_usd_annual":207000,"is_top_pay":true},"html_url":"https://alion.io/job/astrazeneca-associate-principal-scientist-formulation-and-process-design","json_url":"https://alion.io/job/astrazeneca-associate-principal-scientist-formulation-and-process-design.json","meta":{"generated_at":"2026-10-23T15:49:15Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":23748,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-24T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":13195},"rest":"https://alion.io/mcp/rest/get_company?id=13195"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fastrazeneca-associate-principal-scientist-formulation-and-process-design"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fastrazeneca-associate-principal-scientist-formulation-and-process-design"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fastrazeneca-associate-principal-scientist-formulation-and-process-design"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/astrazeneca-associate-principal-scientist-formulation-and-process-design\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fastrazeneca-associate-principal-scientist-formulation-and-process-design"}]}