{"id":4300536,"url":"https://alion.io/job/astrazeneca-director-portfolio-management","title":"Director, Portfolio Management","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":94,"open_postings":188,"ghost_share":0.011,"stale_share":0.356,"repost_share":0.112,"time_to_fill_p50_days":19,"computed_at":"2026-11-12T10:38:37Z"}},"role":"Finance","role_family":"Finance","seniority":"head","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Gaithersburg, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":159180,"max":208924,"currency":"USD","period":"year","gross":null,"usd_annual":208924},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Agile","optional":false},{"name":"Azure DevOps","optional":false},{"name":"GDPR","optional":false},{"name":"ServiceNow","optional":false},{"name":"Azure","optional":true},{"name":"Scrum","optional":true},{"name":"Waterfall","optional":true}],"status":"live","first_seen_at":"2026-11-13T00:00:00Z","employer_posted_date":"2026-11-13","last_verified_at":"2026-11-14T02:57:44Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"WHY JOIN US?\nAt AstraZeneca, we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030, there is no better place to make a difference in medicine, for patients, and in society.\nJoin us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration, and we are always committed to lifelong learning, growth, and development. As part of our team, you'll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca, where your work will have a real impact on improving people's lives.\nRecognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.\nAbout AISI\nAstraZeneca AI for Science Innovation (AISI) is driving the convergence of artificial intelligence and life sciences at enterprise scale. AISI brings together data foundations, AI and machine-learning technology, strategic partnerships, process reinvention, and business-facing AI to accelerate drug discovery, development, and delivery. Success depends on connecting and scaling existing capabilities, promoting reuse, and translating innovation into measurable scientific, patient, and enterprise value.\nThe Opportunity\nThe Director, Portfolio Management will lead the design, governance, and continuous improvement of AISI's portfolio management capability across strategic initiatives, AI and data platforms, external partnerships, projects, suppliers, managed services, and operational investments. The role ensures that strategy is translated into an executable portfolio, investments and resources are directed to the highest-value opportunities, delivery performance is transparent, and financial and operational risk, and compliance governance are embedded throughout the portfolio lifecycle.\nOperating at the intersection of AISI leadership, scientific and therapeutic-area stakeholders, Data Science, Engineering, Finance, Procurement, HR, and external partners, the Director will establish scalable ways of working, strengthen evidence-based decision-making, and deliver outcomes through cross-functional teams and managed-service providers. The role sits within AISI Operations and reports to the Head of AISI Operations.\nScope and Core Accountabilities\n\nPortfolio Strategy, Planning, and Governance\nTranslate AISI strategy and scientific priorities into an integrated portfolio of investments, initiatives, platforms, products, partnerships, and operational services.\nEstablish and continuously improve demand intake, assessment, value-based prioritization, funding, resource allocation, stage-gate review, delivery assurance, and benefits-realization processes.\nMaintain an integrated portfolio view, identifying opportunities to stop, sequence, accelerate, consolidate, reuse, or scale initiatives as priorities and evidence evolve.\nLead portfolio governance forums and provide clear executive reporting on investment, demand, delivery health, dependencies, risks, issues, decisions, capacity, financial performance, and expected value.\nDevelop standardized dashboards and management information that enable timely, transparent, evidence-based decisions without creating unnecessary bureaucracy.\nFinancial and Investment Management\nPartner with Finance and senior leaders to manage long-term investment planning, business cases, budgets, forecasts, and Run and Change expenditure.\nOversee forecast-versus-budget analysis, variance management, accruals, cross-charges, resource recharges, purchase orders, and supplier-related financial commitments.\nEnsure financial information is accurate, timely, transparent, and connected to portfolio priorities, delivery milestones, and benefits realization.\nDefine and track financial and non-financial value measures, including scientific impact, speed, adoption, reuse, risk reduction, productivity, and enterprise scalability.\nOperating Model and Process Excellence\nDesign and evolve the portfolio operating model, decision rights, governance forums, escalation pathways, and RACI frameworks required to manage a complex, global portfolio.\nDrive standardization, simplification, automation, and continuous improvement across portfolio, project, financial, supplier, contracting, resource, onboarding, and service-management processes.\nIntroduce fit-for-purpose Agile, Lean Portfolio Management, Design Thinking, incremental delivery, and hybrid governance practices where appropriate.\nEnsure processes are practical, adopted, and supported by reliable data and fit-for-purpose tools, including ServiceNow, Azure DevOps, and portfolio or financial-management platforms.\nPartnership, Contracting, and Supplier Governance\nProvide end-to-end portfolio oversight of strategic alliances, AI and data partnerships, technology providers, suppliers, and managed services.\nPartner with Legal, Procurement, Finance, Privacy, Information Security, and technical leaders across the contracting lifecycle, from intake, due diligence, term-sheet development, and negotiation through execution, performance review, renewal, and exit.\nImplement supplier and partner governance through scorecards, service-level agreements, periodic business reviews, delivery-quality measures, commercial-health monitoring, risk mitigation, and value-for-money assessments.\nEnsure partner commitments, dependencies, milestones, financial obligations, and benefits are integrated into portfolio planning and reporting.\nResource and Capacity Management\nLead resource and capacity-management practices across projects, products, platforms, partnerships, and operational services.\nOversee workforce planning, allocation, utilization, people recharges, onboarding, and prioritization of scarce scientific, AI, engineering, and portfolio-management capabilities.\nWork with functional leaders to identify capability gaps, resolve constraints, improve onboarding, and align internal and external capacity with strategic priorities.\nRisk, Compliance, and Delivery Assurance\nEstablish portfolio-level approaches to risk, issue, dependency, assumption, and decision management, ensuring material concerns are identified early, escalated appropriately, and managed through resolution.\nProvide oversight of scope, schedule, cost, quality, benefits, adoption, operational readiness, and delivery performance across the portfolio.\nEnsure portfolio activities and external arrangements comply with relevant pharmaceutical and technology requirements, including data governance, GDPR and privacy, information security, intellectual property, procurement, ethical, quality, and regulatory frameworks.\nAnticipate and manage delivery underperformance, supplier failure, commercial disputes, IP complexity, changing priorities, financial pressure, data and technology dependencies, and regulatory constraints.\nStakeholder Engagement and Change Enablement\nBuild trusted relationships with AISI and Enterprise AI leaders, therapeutic and scientific areas, Data Science, Engineering, Finance, Procurement, Legal, HR, Operations, and external partners.\nFacilitate alignment on priorities, investment choices, delivery expectations, trade-offs, and accountabilities across a global matrix organization.\nCommunicate complex portfolio, financial, commercial, and delivery matters clearly to senior leaders and diverse stakeholder groups.\nChampion adoption of portfolio standards, transparent governance, and collaborative delivery while preserving the speed and experimentation required for AI innovation.\nLeadership\nLead and develop high-performing portfolio management, governance, and business-operations capabilities, directly and through matrix teams and managed-service providers.\nCreate a culture of accountability, collaboration, customer focus, continuous improvement, reuse, and measurable value delivery.\nSet clear standards and build scalable capabilities from the ground up, enabling consistent ways of working across functions and geographies.\nContribute to AISI functional strategy and operating model evolution as the organization, technology landscape, and partnership ecosystem mature.\nQualifications and Experience\n\nEssential\nBachelor's degree in business, technology, finance, life sciences, project management, law, data science, or a related discipline; a Master's degree or equivalent extensive professional experience is preferred.\n10+ years of progressive experience across portfolio management, program or project management, business operations, financial management, alliance or partnership management, supplier governance, contracting, or a related discipline in a complex global organization.\nDemonstrated experience leading portfolio management and process-transformation initiatives, including demand intake, value-based prioritization, governance, investment planning, resource allocation, delivery assurance, and benefits realization.\nStrong financial acumen, including business-case development, long-term planning, investment tracking, forecasting, budget management, accruals, variance analysis, cross-charges, purchase orders, and resource recharges.\nExperience managing suppliers, strategic partners, external collaborations, or managed services, including contracts, service levels, performance, commercial risk, value for money, and issue resolution.\nExperience designing and implementing operating models, decision rights, governance forums, processes, RACI frameworks, dashboards, and management information.\nProven success influencing senior leaders and delivering through cross-functional teams, matrix structures, third parties, and managed-service providers.\nAbility to operate with limited direction in ambiguous, fast-moving environments and make sound decisions that balance scientific and strategic value, risk, cost, capacity, compliance, and delivery feasibility.\nExceptional written, verbal, influencing, relationship management, and organizational skills.\nDesirable\nExperience in pharmaceutical, biotechnology, healthcare, life sciences, or another highly regulated technology environment.\nWorking knowledge of AI and machine-learning ecosystems, data partnerships, cloud platforms, digital products, technology platforms, and platform-based delivery models.\nUnderstanding of pharmaceutical research and development and how AI, data, platforms, and external partnerships create scientific and competitive advantage.\nExperience establishing or scaling portfolio management, alliance management, PMO, or business-operations function.\nExperience with Agile, Scrum, SAFe, Lean Portfolio Management, Waterfall, Design Thinking, or hybrid delivery approaches.\nExperience with ServiceNow, Azure DevOps, and comparable portfolio, project, financial, procurement, or service-management tools.\nKnowledge of data governance, privacy, information security, intellectual property, quality, regulatory compliance, and IT risk management.\nProfessional qualifications such as PMP, PRINCE2, MSP, Scrum, SAFe, or equivalent portfolio, program, commercial, or supplier-management credentials.\nLeadership Capabilities\nStrategic thinking: Connects scientific and enterprise strategy to investment choices, delivery priorities, and measurable value.\nEnterprise perspective: Optimizes across the portfolio, promotes reuse and scalability, and avoids isolated solutions.\nExecution discipline: Establishes clear governance and follows through to achieve reliable delivery and benefits realization.\nCommercial and financial judgment: Balances value,...","description_format":"text","description_chars":15673,"description_truncated":true,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Retirement plans"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Oncology Therapeutics","Rare Disease Therapeutics","Cardiometabolic 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