{"id":3875399,"url":"https://alion.io/job/astrazeneca-manufacturing-manager","title":"Manufacturing Manager","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":93,"open_postings":167,"ghost_share":0.012,"stale_share":0.383,"repost_share":0.108,"time_to_fill_p50_days":19,"computed_at":"2026-11-07T05:47:08Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Los Angeles, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":94692,"max":142039,"currency":"USD","period":"year","gross":null,"usd_annual":142039},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CAPA","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-11-06T16:07:20Z","employer_posted_date":"2026-11-06","last_verified_at":"2026-11-07T08:05:09Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"Job Description / Capsule\nThe Manufacturing Manager leads a manufacturing team or assigned shift supporting TCR T, CAR T, and allogeneic cell therapy programs. This role is accountable for safe, compliant, and reliable execution on the direct manufacturing floor, with responsibility for resource management, workload management, right first time execution, schedule adherence, team development, Tier 2 performance management, and cross-functional escalation.\nPurpose and Scope\nThe Manufacturing Manager translates manufacturing strategy into daily execution. This includes managing staffing, scheduling, floor readiness, production flow, deviation support, training progress, and continuous improvement. The role is expected to lead through presence on the floor, strong communication, coaching, one-on-ones, disciplined escalation, and standard work. This role serves as the direct leadership layer between on-floor execution and Associate Director-level strategy.\nTypical Accountabilities\nLead daily manufacturing operations for an assigned shift, area, or functional team.\nProvide on-floor support and oversight as a meaningful portion of the role, with a focus on safety, quality, execution discipline, and team coaching.\nEnsure production activities are executed safely, compliantly, and according to approved procedures.\nManage staffing, scheduling, work assignments, workload management, and production readiness to meet patient supply demand.\nEnsure personnel, materials, equipment, documentation, electronic systems, and cleanroom areas are ready before manufacturing activities begin.\nOversee successful execution of manufacturing batch records, work instructions, and SOPs with a focus on right first time performance.\nMaintain schedule adherence and cycle time expectations by identifying risks early and escalating impacts to Manufacturing leadership.\nLead daily communication to team members, including shift huddles, Tier 1 and Tier 2 meetings, and shift handover expectations.\nOwn or support the Tier 2 manufacturing performance review process, cross-functional board, metrics, action tracking, and escalation to Tier 3 and site leadership when required.\nSupport SQDCP or SQSCP communication by reviewing safety, quality, delivery or supply, cost, and people performance.\nEnsure production updates, shift notes, and action items are clear, accurate, complete, timely, and inspection ready.\nPartner with Quality, MSAT, Process Development, Supply Chain, EHS, and Facilities and Engineering to resolve issues and maintain production flow.\nCreate, own, or support deviation, non-conformance, OOS, CAPA, change control, and manufacturing-related quality records as assigned.\nReview and approve manufacturing documentation as assigned, including SOPs, batch records, logbooks, training materials, and operational procedures.\nLead implementation of new processes, technology transfer activities, engineering runs, process changes, and digital manufacturing tools within the manufacturing area.\nCoach, mentor, and develop Associate Specialists, Manufacturing Specialists, and Lead Cell Therapy Specialists.\nConduct regular one-on-one meetings and maintain development plans for direct reports.\nConduct performance discussions, support career development, and address performance concerns in partnership with HR and leadership.\nIdentify and develop future Lead Specialists and Manufacturing leaders through coaching, delegation, stretch assignments, and succession planning.\nSupport workforce planning, staffing models, capacity planning, and shift structure recommendations to meet current and future demand.\nIdentify and lead continuous improvement initiatives that improve safety, quality, schedule adherence, throughput, cost awareness, and team effectiveness.\nSupport audit and inspection readiness by ensuring the team maintains compliant behaviors, documentation, cleanroom discipline, and visual inspection readiness.\nControl expenses within area of influence, including overtime, supplies, consumables, and resource utilization.\nPerform additional responsibilities and project-based assignments as needed to support Manufacturing operations and business objectives.\nYou Are Accountable For\nSafe, compliant, and right first time execution of assigned manufacturing operations.\nDelivery of production schedules and patient supply commitments.\nEffective management of people, materials, equipment, documentation, electronic systems, and cleanroom readiness.\nTimely escalation of safety, quality, schedule, staffing, material, equipment, facility, or patient supply risks.\nEffective Tier 1/Tier 2 communication, shift handover, and cross-functional escalation.\nManufacturing team performance, development, engagement, accountability, and one-on-one cadence.\nDeviation support, CAPA execution, quality record management, and timely closure of assigned manufacturing actions.\nMaintaining visual inspection qualification coverage and visual inspection readiness within assigned area.\nMaintaining inspection readiness and GMP discipline within assigned area.\nDriving continuous improvement and operational excellence within the team.\nBuilding leadership capability and maintaining succession readiness within the team.\nBuilding a culture of safety, quality, teamwork, accountability, inclusion, and patient focus.\nRequired Qualifications\nMinimum of a High School Diploma with significant relevant experience.\nMinimum of 8-10 years of relevant experience with 3-5 years of leadership experience\nExperience leading teams in a GMP manufacturing environment.\nStrong understanding of cGMP, SOPs, batch records, cleanroom operations, safety requirements, quality systems, and regulated manufacturing environments.\nExperience with cell therapy, biologics, pharmaceutical, biotech, or vector manufacturing.\nDemonstrated ability to manage daily operations, staffing, scheduling, resource management, workload management, and production readiness.\nStrong people leadership, coaching, communication, organization, time management, and decision-making skills.\nAbility to troubleshoot operational issues and assess risk to product, people, plant, and patient supply.\nAbility to work effectively in a fast-paced, complex, and changing manufacturing environment.\nAbility to collaborate and influence across Manufacturing, Quality, MSAT, Process Development, Supply Chain, EHS, and Facilities and Engineering.\nWorking knowledge of FDP visual inspection qualification coverage and defect escalation processes, as applicable\nPreferred Qualifications\nBachelor or Master degree in science, engineering, life sciences, business, or a related discipline.\nExperience in cell therapy manufacturing.\nExperience supporting clinical manufacturing, commercial manufacturing, technology transfer, engineering runs, process validation readiness, or commercial readiness.\nPrior supervisory or people management experience.\nExperience leading deviation investigations, CAPAs, change controls, SOP revisions, batch record improvements, or inspection readiness activities.\nExperience with electronic batch records, MES, inventory systems, quality management systems, or scheduling systems.\nExperience implementing Lean, 5S, visual management, standard work, Tier 2 boards, problem solving, or other operational excellence tools.\nExperience developing Leads or front-line leaders.\nKey Relationships\nInternal: Manufacturing Management, Manufacturing Shop Floor, Quality, MSAT, Process Development, Supply Chain, EHS, Facilities and Engineering, HR, Training, and Site Leadership as needed.\nExternal: Vendors or external partners as assigned.\nWorking Conditions\nMust be able to work in a cleanroom environment that requires gowning as needed to support operations.\nMust be able to work in an office environment with computer screens and artificial overhead lighting.\nMust be able to stand, walk, or sit for extended periods of time.\nMust be able to support manufacturing operations on the floor for moderate to extended periods of time.\nMay work in classified cleanroom environments and with sophisticated automated cell processing, cell expansion, and filling equipment.\nMay work in areas with strong magnets or specialized manufacturing equipment.\nMay work in areas where human blood products or other biological materials are handled.\nMay work in areas with exposure to vapor phase liquid nitrogen or cryogenic materials.\nMay be required to support assigned shifts, weekends, holidays, and overtime based on manufacturing schedule and business need.\nMust follow all safety, contamination control, gowning, documentation, and cGMP requirements.\nGeneral Statement\nThis job description describes the general nature and level of work expected for this role. It does not list every responsibility, duty, or skill required. Employees in this role may be asked to perform other job-related duties as needed to support Manufacturing operations, patient supply, site readiness, commercial readiness, and business priorities.\nThe annual base pay (or hourly rate of compensation) for this position ranges from $94,692.80 - 142,039.20. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.\nDate Posted\n06-Nov-2026Closing Date\n26-Nov-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. 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