Senior Scientist – Asymmetric Catalysis and High-Throughput Experimentation

Senior Scientist - Asymmetric Catalysis and High-Throughput Experimentation

AstraZeneca is a global biopharmaceutical company focused on innovating and delivering life-saving medicines while prioritizing sustainability and minimizing our environmental impact. We foster a collaborative, inclusive culture where colleagues are empowered to share ideas and feel valued and rewarded.

Pharmaceutical Technology & Development (PT&D) transforms cutting-edgescience into medicines for millions, working across the value chain to design, develop, and scale up drug products from early research through commercial manufacture.

In Chemical Development, we combine scientific expertiseand innovation to create and optimizesustainable, commercially viableprocesses for active pharmaceutical ingredients. By collaborating widely and embracing new technologies, we continually improve how we deliver medicines.

Catalysis and High-Throughput Experimentation (HTE) facilitatethe development of efficient and sustainable processes, allowing innovative routes to API (Active Pharmaceutical Ingredient) molecules that are increasing in complexity. The catalysis and HTE group support the development and manufacture of drug projects across the portfolio, from late-discovery to launch, with key expertisein a range of technologies such as cross-coupling, asymmetric reactions, and the use of gases in synthesis.

Job description:

We are offering an exciting Senior Scientist position in asymmetric catalysis and HTE in ourvibrant team, with the successful candidate joining a cutting-edge pharmaceutical lab with access to gloveboxes and state of the artHTE equipment. The responsibilities and requirements of the position are outlined below.

The role is based at the Macclesfield Campus, Cheshire.

Key responsibilities:

• Lab based role involving the design and execution of catalytic reactions with the ability to interpret data, analyse results and plan the next steps accordingly.

• Has a good understanding of reactions relevant to the pharmaceutical industry and an up-to-dateknowledge of the literature in relevant areas of asymmetric catalysisand synthesis.

• Seeks out the most appropriate methodsfor carrying out experimental work to a high standard utilizinghigh-pressure equipment, high-throughput experimentationand automation where appropriate.

• Collaborateswith other members of the catalysis team, drug project teamsor external academic collaborators to contribute to the development of new medicines.

Essential Requirements:

• A PhD aligned to organic synthesisand/or catalysis,orBSc/MScwithrelevant industrial experience to an equivalent level.

• Experience in high-throughput experimentation (HTE) and running pressure reactions, with a strong understanding of safe laboratory practices and relevant experimental procedures.

• An excellent understanding of synthetic reagents and methodologies, reaction mechanismsand modern analytical techniques.

• A record ofscientificinnovation, through publication authorship, patent inventorship, or conferencepresentation.

• The ability to work effectively within a team environment.

Desirable experience and attributes:

• Lab-based pharmaceutical industry and/or process development experiencewith awareness of considerations for design of synthetic routes for scale-up and manufacture of APIs.

• The confidence to coach and drive performance and development among your peers.

• Excellent communication skills, with the ability to communicateacross interfaces of scientific disciplines, culture, and expertiseboth internally and externally.

Please note applications must include your current CV and a coveringletter which presents your key areas of strength and why you should be considered for the role.

Why AstraZeneca?

Make a more meaningful impact to patients’ lives around the globe

With science at its heart, this is where breakthroughs born in the lab become transformative medicines - for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward as we lead the way for healthcare and society.

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development

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