{"id":4300541,"url":"https://alion.io/job/astrazeneca-senior-scientist-bioconjugation","title":"Senior Scientist Bioconjugation","company":{"id":13195,"name":"AstraZeneca","domain":"astrazeneca.com","url":"https://alion.io/company/astra-zeneca","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":93,"open_postings":201,"ghost_share":0.02,"stale_share":0.348,"repost_share":0.129,"time_to_fill_p50_days":19,"computed_at":"2026-11-14T05:58:10Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Macclesfield, United Kingdom"],"countries":["GB"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"GLP","optional":false},{"name":"HPLC","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-11-13T00:00:00Z","employer_posted_date":"2026-11-13","last_verified_at":"2026-11-14T13:03:09Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"Job Description\nThis is an exciting opportunity for a laboratory-based scientist to join the Bioconjugation and Analytical group in Oncology Targeted Discovery (OTD) at The Discovery Centre (DISC), Cambridge UK. You will become part of a team of Bioconjugation scientists and play a pivotal role in the delivery of robust and high-quality data to support drug discovery projects within the Oncology portfolio. Working collaboratively with other disciplines across AstraZeneca, you will have the opportunity to contribute to the research and development for early phase projects. You should have a background in Oncology/Biology/Chemical Biology and a strong passion for experimental work, automation and delivering data from the laboratory. You will use your scientific judgement, strong ability to analyse experimental data and use effective communication skills to contribute to decision making for early-stage drug discovery programmes. As a Bioconjugation Scientist, you'll have a deep understanding of the range of analytical procedures relating to bioanalysis/bioscience. You will expertly design and conduct laboratory projects/experiments, develop automation workflows and analytical methods, and generate, interpret, and report scientific data to relevant stakeholder.\nWhat you’ll do\nDevelop, optimise and scale up drug discovery research lab experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffolds\nDevelop, implement and optimise HT bioconjugation workflows using automation e.g. liquid handlers\nPerform routine interpretation of data with little or no guidance, with a clear understanding of its implications within drug discovery and effectively communicate to relevant stakeholders in a clear and concise manner\nWorks independently within a team and collaboratively with internal and external stakeholder\nMaintains a well-developed understanding of approaches to targeted delivery of therapeutics within Oncology\nRemain up to date with relevant recent advances and relevant technology including published papers/patents with peers\nAuthoring and reviewing relevant documents including laboratory notebooks, protocols and reports\nEnsures own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations\nSkills and Experience\nPh.D in Chemistry, Biochemistry, Bio/Chemical engineering or relevant discipline\nM.Sc or B.Sc in above disciplines with significant relevant industrial experience\nStrong foundation in chemistry, protein biochemistry and bioconjugation\nHands on experience of performing a range of protein/bioconjugate characterisation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC and LCMS, ideally with Antibody-Drug Conjugates\nExperience with executing preparative chromatography purifications using AKTA and TFF systems\nExperience with programming, implementing and optimising automation workflows e.g. with liquid handlers is highly desirable\nKnowledge and strong understanding of developing and optimising robust analytical methods for protein/bioconjugate characterisation might be beneficial\nA track-record of protein/related scaffold modification experience\nProficiency in AI tools and their effective implementation might be beneficial\nWhy AstraZeneca?\nAt AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.\nSo, what’s next?\nAre you already imagining yourself joining our team? Good, because we can’t wait to hear from you.\nAre you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.\nWhere can I find out more?\nOur Social Media,\nFollow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/\nFollow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/\nDate Posted\n13-nov.-2026Closing Date\n27-nov.-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.","description_format":"text","description_chars":4811,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Oncology Therapeutics","Rare Disease Therapeutics","Cardiometabolic Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-14T02:57:44Z"}],"visa":[{"country":"GB","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"Licensed UK visa sponsor (Graduate Trainee, Senior or Specialist Worker, Skilled Worker)","filings_12m":null,"filings_prev_12m":null,"green_card_filings_12m":null,"median_offered_wage_usd":null,"route":"Global Business Mobility: Graduate Trainee; Global Business Mobility: Senior or Specialist Worker; Skilled Worker","cap_exempt":false,"checked_at":"2026-11-14T07:33:33+00:00","sources":["UK Home Office: register of licensed sponsors (workers)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":1,"expected_fill_days":19,"reasons":["conf:3","velocity","win:early","comp:brand"],"computed_at":"2026-11-14T05:58:10Z"},"pay":null,"html_url":"https://alion.io/job/astrazeneca-senior-scientist-bioconjugation","json_url":"https://alion.io/job/astrazeneca-senior-scientist-bioconjugation.json","meta":{"generated_at":"2026-11-14T13:06:40Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":13202,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-15T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":13195},"rest":"https://alion.io/mcp/rest/get_company?id=13195"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fastrazeneca-senior-scientist-bioconjugation"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"free","price":{"credits":0,"usd":0},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fastrazeneca-senior-scientist-bioconjugation"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fastrazeneca-senior-scientist-bioconjugation"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/astrazeneca-senior-scientist-bioconjugation\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fastrazeneca-senior-scientist-bioconjugation"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":4300541}},{"tool":"search_jobs","arguments":{"company":"astrazeneca.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":4300541},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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