Senior Scientist - Cell Therapy Safety

Job Title: Senior Scientist(CLD)-Cell TherapySafety

Location: Cambridge, UK

Do you have a background in cell therapy safety assessment and want to shape the safety strategy for innovative cellular therapeutics? Are you excited to expand yourexpertisein the non-clinical safety assessment of next-generation cellular modalities? If yes, AstraZeneca could have the role for you.

About the role

We areseekinga highly motivated Senior Scientist to join our laboratory-based Cell TherapySafety TeamwithinCell Therapy Translational and Safety Sciences. This role is based at ourstate-of-the-artDiscovery Centre in Cambridge, UK, offering a collaborative environment across disciplines to drive innovation in 21st-century pharmaceutical research.

At AstraZeneca, we value diverse perspectives and inclusive collaboration. We believe teams are most creative when individuals contribute different ideas and experiences in an environment where those differences are welcomed and respected. This is how we foster continuous innovation, learning, and growth-for our people and for patients.

Whatyou’lldo

You will primarily support our growingcellular medicineportfolio;includingautologous,allogeneicand in vivo CAR-T. You will design and execute assays and applymolecular biology andimmunology/cell biologyapproaches to develop methods for assessingpre-clinicalsafety.

Key responsibilities include:

• Model development: Develop andvalidatenew in vitro models to predict and assess toxicity, immunogenicity, and tumorigenicity for cellular therapeutics; contribute to broader non-clinical toxicology packages for novel modalities.

• Scientific problem-solving:Identifyand solve complex scientific problems;championscientific and technological innovations that advance strategic capabilities.

• External engagement: Collaborate with leading academics; publish in high-quality journals; actively contribute to scientific networks and communities.

• Innovation: Drive innovation to support internal and external presentations and publications to strengthen AstraZeneca’s scientific leadership.

• Cross-functional collaboration: Work closely with scientists across CPSS and partnered functions to translate biological insights into safety strategies for pioneering therapeutics.

Essential qualifications and experience

• PhD or equivalent in immunology, cellular biology, or a related discipline.

• Strong scientifictrack recordinimmunologyand/or molecular biologyandcell therapydevelopment, with practical experience inmolecular biology,flow cytometry, cell therapy discovery, andideallytoxicology assessment; post-doctoral experience preferred.

• Experience designing and/or executing in vitro and/or in vivo studies todeterminesafety and/or efficacy of cellular therapeutics.

• Preferably, experience as a safety scientist incell therapy development from project conception throughtocandidateselection.

• Demonstrated ability to work effectively in multi-disciplinary teams withstrong communicationskills (presenting, manuscript preparation, influencing, relationship building).

• Excellent publication record,commensuratewith career stage.

• Ability tooperatein compliance with Good Laboratory Science standards, Safety, Health & Environment requirements, and relevant external regulations.

Who you are

You are a motivated, creative, and innovative scientist with a collaborative, team-oriented mindset. You enjoy solving complex problems with a goal-focused approach and havestrong communication

and presentation skills. You thrive in an open, positive, and collaborative working environment.

Why AstraZeneca

At AstraZeneca, curiosity and courage drive our science.We’reinspired by the possibility of doing what has not been done before. Empowered to step up, we challenge fear of failure, explore the biology of complex diseases, and make bold decisions-celebrating successes and learning from setbacks along the way.We have the ambition to be a world leader in cell therapydevelopment to meet the unmetcurativeneeds in oncology and autoimmune diseases.

What’snext

Are you imagining yourself in this role? We invite you to apply today.

Pleasesubmityour application bySeptember2026.

For further details, contact Recruiting Manager: Mick Fellows at [email protected].

Date Posted

Closing Date