{"id":462034,"url":"https://alion.io/job/bighat-biosciences-scientist-ii-developability","title":"Scientist II, Developability","company":{"id":177947,"name":"BigHat Biosciences","domain":"bighatbio.com","url":"https://alion.io/company/bighat-biosciences","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Pinpoint","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Mateo, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":145000,"max":165000,"currency":"USD","period":"year","gross":null,"usd_annual":165000},"salary_estimate":null,"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Antibody Engineering","optional":false},{"name":"ELISA","optional":false},{"name":"LIMS","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-09-05T11:22:38Z","employer_posted_date":"2026-10-22","last_verified_at":"2026-10-25T15:10:25Z","board_verified":true,"closed_at":null,"days_open":50,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":50},"description":"The Role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.\n*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that \nresponsibilities and title would adjust as appropriate. \nKey Responsibilities\nLead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat’s toolkit.\nDrive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.\nSupport late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.\nServe as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.\nWork cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.\nProactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.\nSkills Knowledge and Expertise\nPhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.\nStrong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.\nTrack record of translating complex data into clear results and recommended actions.\nExperience with protein structures and antibody engineering.\nEnthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.\nNice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation. \nTotal Rewards\nThe salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.\nWhat BigHat Offers:\nRange of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)\nDental, and vision coverage through Guardian\nAdditional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more\n401(k) with company match \nDTO, two weeks of company-wide shutdown, and 12 company holidays\nPaid parental leave","description_format":"text","description_chars":3035,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Health insurance","Parental leave"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery","Biologics & Biosimilars","Drug Discovery AI"],"lifecycle":[{"event":"open","at":"2026-09-06T11:22:38Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 2","filings_12m":2,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":102500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":25,"band":"fade","label":"Fading","p_open":1,"p_active":0.546,"p_room":0.45,"age_days":49,"expected_fill_days":31,"reasons":["conf:1","win:tail"],"computed_at":"2026-10-25T05:49:26Z"},"pay":{"stated_usd_annual":165000,"is_top_pay":true},"html_url":"https://alion.io/job/bighat-biosciences-scientist-ii-developability","json_url":"https://alion.io/job/bighat-biosciences-scientist-ii-developability.json","meta":{"generated_at":"2026-10-25T18:10:22Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":26005,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-26T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":177947},"rest":"https://alion.io/mcp/rest/get_company?id=177947"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fbighat-biosciences-scientist-ii-developability"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fbighat-biosciences-scientist-ii-developability"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fbighat-biosciences-scientist-ii-developability"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/bighat-biosciences-scientist-ii-developability\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fbighat-biosciences-scientist-ii-developability"}]}