{"id":3035899,"url":"https://alion.io/job/broad-institute-postdoctoral-associate-computational-biology-xavier-lab","title":"Postdoctoral Associate, Computational Biology - Xavier Lab","company":{"id":15717,"name":"Broad Institute","domain":"broadinstitute.org","url":"https://alion.io/company/broad-institute","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Avature","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":null,"employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":115000,"max_usd":263000,"period":"year","method":"role_country_seniority_unknown","sample_n":1243},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CRISPR","optional":false},{"name":"Next-Generation Sequencing","optional":false},{"name":"PubMed","optional":false},{"name":"Python","optional":false},{"name":"Single-Cell Sequencing","optional":false}],"status":"live","first_seen_at":"2026-10-21T21:22:04Z","employer_posted_date":"2026-10-21","last_verified_at":"2026-11-05T06:04:26Z","board_verified":true,"closed_at":null,"days_open":14,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":14},"description":"The Broad Institute of MIT & Harvard is seeking a highly motivated Postdoctoral Associate to join the Xavier Lab and Klarman Cell Observatory and lead data analysis and algorithm development designed to determine the underlying factors contributing to health and disease, with a strong focus on discovering disease mechanisms at the level of their molecular and cellular pathways.\nWe are an interdisciplinary group with expertise in computational biology, functional genomics, microbiology, and immunology. The candidate for this position will be working closely with computational and experimental biologists, including Principal Investigators, graduate students, and staff scientists in the group. They will contribute by directing, planning, and executing the analyses of large multi-omic datasets with the goal of identifying biological features (e.g., variants, genes, microbes) that are relevant to human health.Prospective applicants should have made significant contributions to their area of study, as evidenced by a strong publication record. We are seeking creative and highly motivated individuals who want to work in a dynamic, multi- disciplinary research environment.\nThe ideal candidate will be the computational analysis lead for projects discovering the mechanisms behind inflammatory and autoimmune diseases. They should have excellent technical expertise while being driven to make a biological impact. In particular, we are seeking a postdoc to take primary leadership for analyzing spatial and single-cell multiomics datasets collected from human tissue samples as well as mouse models.\nResponsibilities\nOversee data generation and data analysis across various internal and external collaborations. Includes working datasets such as single-cell RNA-Seq, single-cell ATAC-Seq, spatial transcriptomics, proteomics, metabolomics, and/or microbiome data.\n\nDemonstrate flexibility to execute tasks requiring various skill levels and learn new skills as needed.\n\nPerform analyses using current processes and identify, propose, and implement improvements to ensure output of high-quality datasets.\n\nWork with other team members and leadership to plan project requirements and timelines, shift priorities as needed, and efficiently execute project tasks.\n\nIdentify and help solve methodological problems, including adjustments to experimental and computational protocols to ensure generation of high-quality datasets suited to answer core biological questions.\n\nUse single cell and spatial transcriptomic approaches to understand tissue organization and how they are altered in disease environments such as chronic inflammation.\n\nUse a systems medicine approach to understand inflammatory and other diseases.\n\nDevelop novel methods to facilitate exploration of unstructured datasets.\n\nWrite well-crafted, maintainable, scalable, and performant code.\n\nLead and carry out projects with minimal supervision.\n\nParticipate in writing papers and grant proposals.\n\nPresent project progress during group meetings.\n\nQualifications\nPh.D. in Computational Biology, Computer Science, Physics, Math, Statistics, or related quantitative fields and strong knowledge of a variety of biological areas of research with 0+ years of experience within the field.\n\nScientific and numerical programming in Python or R and knowledge of class ML methods and deep learning methods.\n\nWell versed in a variety of bioinformatic analyses, including Next Generation Sequencing pipelines (single-cell RNA-Seq, single-cell ATAC-Seq, spatial transcriptomics analyses etc...).\n\nExcellent critical thinking, research, and analytical skills.\n\nExcellent communication and interpersonal skills and the ability to work with biologists, computational biologists, data scientists, and software engineers.\n\nMust be able to work independently as well as part of a team in a fast-paced, highly collaborative environment.\n\nDemonstrated ability to carry out a variety of tasks in parallel, recognize and solve problems effectively, and shift priorities rapidly.\n\nSelected Publications\nIntra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis\nhttps://pubmed.ncbi.nlm.nih.gov/31348891/\nThe landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon\nhttps://pubmed.ncbi.nlm.nih.gov/36720220/\nBidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit\nhttps://pubmed.ncbi.nlm.nih.gov/41501466/\nPopulation-scale multiome immune cell atlas reveals complex disease drivers\nhttps://www.medrxiv.org/content/10.1101/2025.11.25.25340489v1\nA structure-informed deep learning framework for modeling TCR-peptide-HLA interactions\nhttps://www.biorxiv.org/content/10.64898/2026.03.31.715361v2.full\nBridging AI and biology: Foundation models meet human physiology and disease\nhttps://pubmed.ncbi.nlm.nih.gov/41519120/\nThe expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.\nThe expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.\nAt Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.\nThe Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.\nShould you need a reasonable accommodation to complete the application or interview process, please contact  for assistance.","description_format":"text","description_chars":6676,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Retirement plans"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Bioinformatics","Genomics & Genetic Testing","Nonprofits & Foundations","Research Institutes"],"lifecycle":[{"event":"open","at":"2026-10-21T21:22:04Z"}],"visa":[],"liveness":{"score":34,"band":"fade","label":"Fading","p_open":1,"p_active":0.611,"p_room":0.55,"age_days":14,"expected_fill_days":12,"reasons":["conf:5","velocity","win:tail"],"computed_at":"2026-11-05T05:54:30Z"},"pay":null,"html_url":"https://alion.io/job/broad-institute-postdoctoral-associate-computational-biology-xavier-lab","json_url":"https://alion.io/job/broad-institute-postdoctoral-associate-computational-biology-xavier-lab.json","meta":{"generated_at":"2026-11-05T11:19:14Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":14520,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-06T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":15717},"rest":"https://alion.io/mcp/rest/get_company?id=15717"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fbroad-institute-postdoctoral-associate-computational-biology-xavier-lab"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fbroad-institute-postdoctoral-associate-computational-biology-xavier-lab"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fbroad-institute-postdoctoral-associate-computational-biology-xavier-lab"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/broad-institute-postdoctoral-associate-computational-biology-xavier-lab\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fbroad-institute-postdoctoral-associate-computational-biology-xavier-lab"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3035899}},{"tool":"search_jobs","arguments":{"company":"broadinstitute.org","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3035899},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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