{"id":1643956,"url":"https://alion.io/job/c4therapeutics-principal-scientist-formulations","title":"Principal Scientist, Formulations","company":{"id":3783547,"name":"C4 Therapeutics","domain":"c4therapeutics.com","url":"https://alion.io/company/c4therapeutics","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"ADP","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Watertown, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":230090,"max":254310,"currency":"USD","period":"year","gross":null,"usd_annual":254310},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-09-24T14:22:00Z","employer_posted_date":"2026-09-24","last_verified_at":"2026-10-31T01:11:44Z","board_verified":true,"closed_at":null,"days_open":36,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":36},"description":"About C4 Therapeutics:\nC4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.\nJob Summary\nWe are seeking an experienced and highly collaborative Small Molecule Drug Product Formulation specialist to lead the design, early-phase development, and manufacturing scale-up of our oral solid dose drug product candidates. In this role, you will drive the progression of pipeline molecules from initial pre-formulation characterization through successful technology transfer into GMP manufacturing for clinical trials. You will serve as the technical lead overseeing external contract manufacturing organizations, reviewing production records, and continuously optimizing drug product formulations to align with our target product profiles (TPP). This role requires a strong balance of hands-on technical expertise and cross-functional leadership, working in lockstep with internal Discovery, Supply Chain, Quality, and external CDMO partners.\nYour Role\nLead phase-appropriate small molecule drug product formulation development for C4T’s clinical portfolio, applying scientific principles to design, optimize, and scale robust formulations that meet target product profiles, stability requirements, and clinical delivery needs.\nOversee formulation development, process optimization, scale-up, and technology transfer activities for oral drug products, working closely with external CDMOs and contract manufacturing partners to ensure scalable, GMP-compliant manufacturing processes.\nDirect and evaluate the work of external scientists and suppliers, including vendor identification, RFP technical input, CDMO selection, and review of emerging formulation, manufacturing, and analytical data.\nProvide technical leadership for engineering, clinical, and validation batches by reviewing master batch records, executed production documents, change controls, deviations, and analytical data to ensure alignment with GMP requirements and product specifications.\nSupport CMC strategy and regulatory readiness by authoring and reviewing technical memos, specifications, and relevant sections of regulatory filings, including INDs and IMPDs.\nServe as the drug product technical representative across Discovery, Supply Chain, Quality Assurance, Tech Ops, project management, and external partners, building effective relationships and helping establish efficient process development practices.\nYour Background\nRequired:\nA PhD in in Pharmaceutical Chemistry, Formulation Sciences, or related scientific discipline with a minimum of eight years of post-graduate experience, including time spent in an industry setting with hands-on experience in formulation development, process optimization, scale-up, technology transfer, and manufacturing of solid oral and parenteral dosage forms of small molecules, developing excellent science-based problem-solving and critical-thinking abilities. \nExperience in a cross functional drug product leadership role advancing clinical-stage programs that requires frequent interaction with internal and external stakeholders relevant to early & late-stage product development, with strong written communication skills for authoring regulatory documents.\nFamiliarity with quality-by-design (QbD) approaches to drug product development, working knowledge of Good Manufacturing Practices (cGMPs) and Regulatory Guidance Documents as they relate to manufacture and quality testing of pharmaceutical products.\nExperience with creating RFPs, and managing CDMOs performance for formulation development, process optimization, and manufacturing of drug product.\nAbility to multi-task and manage several projects in parallel, interpret and present data to all levels of stakeholders, design tests, and articulate results in an effective manner with a sense of urgency to drive development progress.\nCompensation\nThe base pay range for this position at commencement of employment is expected to be between $230,090.00 and $254,310.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.\nC4 Therapeutics is an Equal Opportunity Employer.","description_format":"text","description_chars":4829,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":[],"lifecycle":[{"event":"open","at":"2026-10-01T22:49:53Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"Filed H-1B visas in the last two years","filings_12m":0,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":null,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":37,"band":"fade","label":"Fading","p_open":1,"p_active":0.676,"p_room":0.55,"age_days":35,"expected_fill_days":32,"reasons":["conf:2","win:tail"],"computed_at":"2026-10-30T05:48:23Z"},"pay":{"stated_usd_annual":254310,"is_top_pay":true},"html_url":"https://alion.io/job/c4therapeutics-principal-scientist-formulations","json_url":"https://alion.io/job/c4therapeutics-principal-scientist-formulations.json","meta":{"generated_at":"2026-10-31T04:10:15Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":5835,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-01T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":3783547},"rest":"https://alion.io/mcp/rest/get_company?id=3783547"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fc4therapeutics-principal-scientist-formulations"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fc4therapeutics-principal-scientist-formulations"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fc4therapeutics-principal-scientist-formulations"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/c4therapeutics-principal-scientist-formulations\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fc4therapeutics-principal-scientist-formulations"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1643956}},{"tool":"search_jobs","arguments":{"company":"c4therapeutics.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1643956},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); 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