{"id":1239124,"url":"https://alion.io/job/cascadebio-process-engineer","title":"Process Engineer","company":{"id":3802036,"name":"Cascade Biocatalysts","domain":"cascadebio.com","url":"https://alion.io/company/cascadebio","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Breezy","truth_index":null},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Denver, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":70000,"max_usd":128000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":4330},"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-09-21T18:04:08Z","employer_posted_date":"2026-09-21","last_verified_at":"2026-11-12T14:20:31Z","board_verified":true,"closed_at":null,"days_open":52,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":52},"description":"Job Title: Process Engineer\nLocation: Denver, CO (on-site)\nType: Full-time\nJob Description:\nCascade Biocatalysts is building the next generation of industrial biocatalysts and is seeking a hands-on Process Development Scientist to join and lead our process development, intensification, and scale-up efforts.\nThis is a foundational role at Cascade Bio. You will be the person who builds our process development function, setting technical direction, establishing SOPs and standards, and owning the path from bench-scale proof of concept to a process that works at commercial scale. You will work directly with the founding team, with ownership over outcomes and the opportunity to shape not just the science but the culture and direction of the company.\nThe right candidate is a subject matter expert on process development and is as comfortable running reactions at the bench as they are thinking about cost per kilogram and scale-up implications. The ideal candidate comes from a CDMO or industrial process chemistry group, and is now ready to bring that instinct and experience to a place where their work will have direct and visible impact.\nKey Responsibilities\nOwn process development end-to-end, from initial catalyst hits to optimized ready to scale processes\nRun and optimize enzymatic reactions, driving process intensification by improving space-time yield, reducing catalyst loading, extending catalyst lifetime, and lowering overall process costs\nCollaborate with our enzyme immobilization team to evaluate and implement heterogeneous catalyst formats\nEvaluate and implement new equipment and process analytical technology solutions\nLead and grow a small process development team over time, mentoring junior scientists while maintaining a technical culture and standards\nBuild and maintain techno-economic models tracking key process metrics: E-factor, PMI, catalyst cost contribution, and downstream processing implications\nInterface with protein engineering efforts, translating process bottlenecks into enzyme engineering targets and back-integrating improved variants\nContribute broadly across the organization: at this stage of the company, the most impactful team members bring their expertise to problems beyond their core scope\nStrong communication skills and ability to balance multiple priorities in a fast-paced, cross-functional and dynamic environment across a variety of programs\nQualifications\nPhD or MS in biochemistry, chemical engineering, organic chemistry, or a related field with a strong catalysis, biocatalysis or heterogeneous catalysis focus\nMinimum of 4 years of experience in process development including scale up, continuous improvements and commercial catalyst development\nDemonstrated ability to improve process performance against real commercial targets, including yield, cost, throughput, not just feasibility\nExperience with techno-economic modeling and process analytical tools\nFamiliarity with DOE-driven development and comfort using data systematically to guide decisions\nExperience working across disciplines, including protein engineering, analytical chemistry, and engineering, and translating between scientific and commercial priorities\nPrior experience at a biocatalysis-focused company, CDMO, or industrial process chemistry group strongly preferred\nComfort operating in an early-stage environment with limited resources, ambiguity, and ambitious goals\nAbout Cascade Biocatalysts\nCascade Bio is an equal opportunity employer. We welcome and encourage diversity in the workplace and strongly encourage candidates from all backgrounds to apply.\nAt Cascade Biocatalysts, we are commercializing our Body Armor for Enzymes™, a polymer science innovation that makes enzymes rugged and reliable for cost-effective biomanufacturing. Our platform unlocks the power of enzymes to replace traditional, unsustainable chemical processes and supports the buildout of a resilient and clean chemical industry.\nWe are a small and growing team, passionate about bridging biology and chemistry to build the future of manufacturing. 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