{"id":2370587,"url":"https://alion.io/job/colossal-scientist-genome-engineering","title":"Scientist, Genome Engineering","company":{"id":673658,"name":"Colossal","domain":"colossal.com","url":"https://alion.io/company/colossal-4","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Dallas, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":65000,"max_usd":176000,"period":"year","method":"role_country_seniority_unknown","sample_n":3131},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-10-12T14:48:55Z","employer_posted_date":"2026-10-12","last_verified_at":"2026-10-13T07:05:31Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"An affiliate of Colossal is hiring a Scientist to develop and implement genome engineering strategies for non-model mammalian organisms. The candidate will design and produce reagents for CRISPR/Cas9, prime editing, base editing, and additional modalities as needed; develop strategies for multiplex genome editing coupled with comprehensive genotyping assays; and independently analyze editing outcomes using appropriate bioinformatics tools. This hands-on role requires a scientist with established technical expertise who can contribute immediately, innovate, and collaborate closely with Cell Engineering teams responsible for cellular delivery and production of edited cell lines.\nThis position is based on-site in Dallas, TX. Relocation assistance is available.\nDuties and Responsibilities:\nDesign, execute, and optimize CRISPR/Cas9, prime editing, and base editing strategies, including multiplex editing of multiple genomic targets.\nDesign and generate guide RNAs, pegRNAs, donor templates, expression constructs, and other genome editing reagents; oversee their validation and quality control.\nInnovate and troubleshoot editing strategies to improve efficiency, specificity, reproducibility, and scalability in non-model mammalian systems.\nApply knowledge of molecular genetics and DNA repair pathways to guide editing strategy, reagent design, troubleshooting, and interpretation of complex editing outcomes.\nIndependently design comprehensive genotyping assays to confirm intended edits, quantify editing efficiencies, and identify unintended or complex editing outcomes.\nAnalyze Sanger and next-generation sequencing data using appropriate bioinformatics tools and pipelines; interpret allelic outcomes and use results to guide experimental decisions.\nWork closely with Cell Engineering scientists to coordinate reagent transfer, experimental designs, editing readouts, and optimization of workflows.\nPlan and execute experiments to meet project milestones; communicate results through reports, presentations, and team meetings.\nMaintain accurate experimental records, reagent documentation, and organized laboratory workflows.\nRequired Skills and Abilities:\nDemonstrated hands-on expertise in mammalian CRISPR/Cas9 genome editing and at least one advanced editing modality (prime editing or base editing), with working knowledge of the other.\nDemonstrated experience designing and executing multiplex genome editing strategies and troubleshooting complex editing outcomes.\nStrong foundational knowledge of molecular genetics, genome organization, and DNA repair mechanisms, including mismatch repair (MMR), homology-directed repair (HDR), and non-homologous end joining (NHEJ), and their implications for editing efficiency, precision, and outcomes.\nAdvanced molecular biology skills, including guide design, DNA assembly and cloning, nucleic acid reagent preparation, and sequence verification.\nProven ability to independently design robust genotyping assays, including junction and allele-specific PCR, sequencing-based assays, and quantitative evaluation of editing outcomes.\nHands-on proficiency with bioinformatics tools for analysis of long- and short-read NGS editing data, including interpretation of indels, substitutions, and mixed or multiplex genotypes.\nDemonstrated scientific innovation, independent experimental design, critical data analysis, and creative problem-solving.\nAbility to execute established workflows independently from the outset and adapt quickly in a fast-paced, collaborative startup environment.\nStrong organizational skills, attention to detail, and written and oral communication skills.\nPreferred Experience:\nHands-on experience with both prime editing and base editing, including editor and guide optimization.\nExperience with complex genomic modifications, HDR donor design, large insertions, or integrase/recombinase-based approaches.\nExperience with in vitro transcription, RNA purification, and reagent QC.\nExperience evaluating off-target editing, structural variants, copy number, and allele phasing using sequencing or orthogonal molecular assays.\nExperience with genome editing analysis pipelines and reproducible computational workflows.\nRequired Education and Experience:\nPhD in genetics, molecular biology, genome engineering, synthetic biology, or a related field.\nDemonstrated independent, hands-on experience developing and applying genome editing strategies in mammalian systems; candidates must be ready to contribute immediately with minimal technical training.\nWhat Colossal Offers Full-Time Employees:\nMedical, dental, and vision coverage\nExcellent paid time off and company holidays so you can rest and recharge \nFlexible spending accounts (FSA)\nCompany matched 401k retirement plan\nPaid parental leave at 100% salary for up to 12 weeks\nEducation reimbursement \nAn opportunity to help us return the Earth to a healthier state\nThe team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. \nThrough it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.\nColossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. \nEEO is the Law \nSearch Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. \nColossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:\n#1 on the 50 Best Startups to Work For in Dallas in 2023!\n100 Best Midsize Places to Work in Dallas in 2024 & 2025\n100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.\nBuilt In 2026 Award Lists\nGreat Place to Work Certification Page\nMost Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.\nNewsweek's Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!","description_format":"text","description_chars":6664,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Parental leave","Relocation assistance","Retirement plans"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":true,"industries":["Synthetic Biology","Environmental Biotechnology"],"lifecycle":[{"event":"open","at":"2026-10-12T17:29:32Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":0,"expected_fill_days":48,"reasons":["conf:1","win:early"],"computed_at":"2026-10-13T05:45:00Z"},"pay":null,"html_url":"https://alion.io/job/colossal-scientist-genome-engineering","json_url":"https://alion.io/job/colossal-scientist-genome-engineering.json","meta":{"generated_at":"2026-10-13T09:42:22Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":14725,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-14T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":673658},"rest":"https://alion.io/mcp/rest/get_company?id=673658"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fcolossal-scientist-genome-engineering"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fcolossal-scientist-genome-engineering"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fcolossal-scientist-genome-engineering"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/colossal-scientist-genome-engineering\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fcolossal-scientist-genome-engineering"}]}