{"id":1460133,"url":"https://alion.io/job/crisprtx-director-lnp-discovery","title":"Director, LNP Discovery","company":{"id":1892348,"name":"crisprtx","domain":"crisprtx.com","url":"https://alion.io/company/crisprtx","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":75,"open_postings":4,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-09-30T05:45:00Z"}},"role":"Sales","role_family":"Sales","seniority":"head","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":195000,"max":215000,"currency":"USD","period":"year","gross":null,"usd_annual":215000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-05-19T00:00:00Z","employer_posted_date":"2026-05-19","last_verified_at":"2026-09-29T11:54:35Z","board_verified":true,"closed_at":null,"days_open":135,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":134},"description":"Job Description:\nCompany Overview\nSince its inception over a decade ago, CRISPR Therapeutics hastransformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics hasestablished strategic partnerships with leading companies including Vertex Pharmaceuticals. CRISPRTherapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPRTherapeutics, Inc., and R&D operations based in Boston, Massachusetts and SanFrancisco, California.\nPosition Summary\nCRISPR Therapeutics is seeking an individual with deep expertise in the RNA delivery space to lead our mRNA delivery efforts. Reporting to the Head of Translational Biology, they will oversee the development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery. The successful candidate must be able to work in a fast paced and highly dynamic Biotech environment. The ideal candidate will be a leader and a great team player with excellent communication skills and an effective, inspiring management style.\nResponsibilities\nOversee the development of novel LNPs (e.g., lipid chemistry, composition, formulation process)\nOversee the development of cell-based assays and animal models for LNP testing.\nLead LNP Delivery biology efforts, including protein design and bioconjugation to ensure successful LNP optimization\nCollaborate cross-functionally with pharmacology and programming teams to achieve key milestones\nDrive the company’s RNA extrahepatic delivery strategy, with a particular emphasis on IP and key deliverables\nStay up to date on RNA delivery literature and prepare technical reports and white papers\nPrepare technical documents and manuscripts for IP filings and publications\nPresent scientific findings internally and externally at key scientific conferences and industry events\nMinimum Qualifications\nPhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field\n10+ years of experience with lipid nanoparticles, siRNA, and protein design\nDemonstrated experience successfully translating animal models from mouse to non-human primate\nExcellent communication skills (oral and written)\nTrack record of innovation in LNP research, spanning bioconjugation, protein design and/or binder design\nStrict record keeping skills (eLN)\nProven team leader with a track record of strong research team leadership\nAbility to synthesize various inputs and make recommendations on strategic approaches we can take as a company in the area of LNP research\nAbility to operate effectively in both detail and high-level settings and strength in navigating\nAbility to think strategically and influence others, and approach challenges with a proactive, ownership mindset\nPreferred Qualifications\nBiotech Industry experience\nKnowledge of the drug development process\nCompetencies\nCollaborative - Openness, One Team\nUndaunted - Fearless, Can-do attitude\nResults Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.\nEntrepreneurial Spirit - Proactive. Ownership mindset.\nDue to the nature of their work, our manufacturing and lab-based positions are located fully on-site.\nDirector, LNP Discovery: Base pay range of $195,000 to $215,000+ bonus, equity and benefits\nThe range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.\nCRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.\nTo view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy","description_format":"text","description_chars":4403,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Health Care","Cell & Gene Therapy"],"lifecycle":[{"event":"open","at":"2026-09-29T11:54:35Z"}],"liveness":{"score":14,"band":"cold","label":"Long shot","p_open":1,"p_active":0.515,"p_room":0.28,"age_days":134,"expected_fill_days":34,"reasons":["conf:17","win:tail","crowd:"],"computed_at":"2026-09-30T05:45:00Z"},"pay":{"stated_usd_annual":215000,"is_top_pay":false},"html_url":"https://alion.io/job/crisprtx-director-lnp-discovery","json_url":"https://alion.io/job/crisprtx-director-lnp-discovery.json","meta":{"generated_at":"2026-10-01T01:50:33Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","usage":{"tier":"crawler","counted_by":"address","units_charged":1,"used_today":1368,"day_limit":5000,"remaining_today":3632,"minute_limit":60,"resets_at":"2026-10-02T00:00:00Z"}}}