{"id":3654990,"url":"https://alion.io/job/crisprtx-scientist-i-computational-biology","title":"Scientist I, Computational Biology","company":{"id":1892348,"name":"crisprtx","domain":"crisprtx.com","url":"https://alion.io/company/crisprtx","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":87,"open_postings":3,"ghost_share":0,"stale_share":0.333,"repost_share":0,"time_to_fill_p50_days":63,"computed_at":"2026-11-04T06:34:25Z"}},"role":"Biotech","role_family":"Biotech","seniority":"junior","employment_type":"full_time","work_mode":"remote","remote_scope":"stated_countries","remote_scope_basis":"board_field","remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":["US"],"hiring_countries_total":1,"salary":{"min":120000,"max":130000,"currency":"USD","period":"year","gross":null,"usd_annual":130000},"salary_estimate":null,"experience_years_min":8,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"AWS","optional":false},{"name":"CRISPR","optional":false},{"name":"Exa","optional":false},{"name":"Linux","optional":false},{"name":"Python","optional":false},{"name":"Angular","optional":true},{"name":"Django","optional":true},{"name":"Flask","optional":true},{"name":"Java","optional":true},{"name":"JavaScript","optional":true},{"name":"Machine Learning","optional":true},{"name":"MySQL","optional":true},{"name":"Next-Generation Sequencing","optional":true},{"name":"TypeScript","optional":true}],"status":"live","first_seen_at":"2026-11-02T00:00:00Z","employer_posted_date":"2026-11-02","last_verified_at":"2026-11-04T19:13:04Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Job Description:\nCompany Overview\nFounded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogeneautotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependentbeta thalassemia. CRISPRTherapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics hasestablished strategic collaborations with leading biopharmaceutical partners, including VertexPharmaceuticals. CRISPRTherapeutics AG is headquartered in Zug, Switzerland,with its wholly-owned U.S. subsidiary, CRISPRTherapeutics, Inc., and R&D operations based in Boston, Massachusetts and SanFrancisco, California.\nPosition Summary\nWe are seeking a Computational Biology Scientist to join the Genomics and Computational Biology team at CRISPR Therapeutics. The scientist in this role will apply computational genomics to advance next-generation gene editing therapies toward the clinic, including characterizing gene-editing safety, tackling challenging bioinformatics and computational biology problems, and maintaining and developing the computational infrastructure, analysis platforms, and internal web applications that support this work. The successful candidate will collaborate closely with cross-functional research groups across the organization. The position requires strong computational biology and genomics skills, scientific rigor, attention to detail, and a passion for creating new medicines for patients.\nResponsibilities\nLead computational biology and genomics activities in a cross-functional drug development setting\nDevelop and implement novel computational biology pipelines and methods in close collaboration with cell/molecular biologists to support therapeutic development and research activities\nPerform computational analyses to thoroughly characterize off-target gene editing to ensure the safety of CRISPR-based drug products\nGenerate and test hypotheses on genome-scale data using analytical and statistical methods\nAuthor scientifically rigorous research reports to support IND submissions and other regulatory filings, and routinely present scientific findings to leadership to guide decision-making for therapeutic programs\nMaintain and develop the computational infrastructure and platforms used for reproducible genomic data analysis, including dedicated cloud computing environments\nMaintain and develop internal web applications that make analysis methods and results accessible to scientific stakeholders\nMinimum Qualifications\nPh.D. in computational biology, bioinformatics, genomics, computer science, or a related field, with 0-2+ years of industry experience. An M.S with an exceptional track record and eight or more years of relevant experience will also be considered\nDemonstrated record of developing successful computational pipelines for high-throughput DNA sequencing data and of using common bioinformatics tools (e.g., BWA, SAMtools, BEDTools, GATK, IGV)\nProficiency in Python is essential\nExperience with Linux and with handling large-scale genomic datasets, and working knowledge of the development and maintenance of computational infrastructure in a cloud computing environment (e.g., AWS)\nAbility to work independently and effectively in a matrix environment, prioritize and manage multiple tasks simultaneously, and balance competing priorities\nCommitment to scientific rigor, accuracy, and meticulous attention to detail\nPreferred Qualifications\nAt least two years of industry experience developing bioinformatics tools for gene editing and/or clinical diagnostic applications\nFamiliarity with programming languages, such as R and Java, and with workflow managers such as Nextflow\nProficiency with the application of NGS tools to characterize the on-target, off-target, and translocation profiles of gene-edited cellular products\nFamiliarity with sequencing platforms (Illumina, PacBio, Oxford Nanopore, 10x Genomics) and NGS library preparation methods\nExperience with web development frameworks (e.g., Django, Flask), front-end frameworks (e.g., React, Angular), and relational databases (e.g., MySQL)\nProficiency with statistical and machine learning methods, and experience applying them to genomic data\nExcellent writing and presentation skills, with the ability to author rigorous scientific reports and communicate findings to diverse audiences; demonstrated record of authoring research reports to support regulatory filings (e.g., IND modules, Investigator's Brochures)\nCompetencies\nCollaborative - Openness, One Team\nUndaunted - Fearless, Can-do attitude\nResults Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.\nEntrepreneurial Spirit - Proactive. Ownership mindset.\nCRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect. Certain lab based and manufacturing positions are located fully on-site.\nScientist I: Base pay range of $120,000 to $130,000+ bonus, equity and benefits\nCRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.\nTo view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy","description_format":"text","description_chars":6359,"description_truncated":false,"requirements":{"experience_years_min":8,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Bioinformatics","Biotechnology","Health Care","Cell & Gene Therapy"],"lifecycle":[{"event":"open","at":"2026-11-03T01:31:47Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":2,"expected_fill_days":63,"reasons":["conf:1","win:early","comp:junior"],"computed_at":"2026-11-04T06:34:25Z"},"pay":{"stated_usd_annual":130000,"is_top_pay":true},"html_url":"https://alion.io/job/crisprtx-scientist-i-computational-biology","json_url":"https://alion.io/job/crisprtx-scientist-i-computational-biology.json","meta":{"generated_at":"2026-11-05T03:14:16Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":4255,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-06T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1892348},"rest":"https://alion.io/mcp/rest/get_company?id=1892348"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fcrisprtx-scientist-i-computational-biology"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fcrisprtx-scientist-i-computational-biology"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fcrisprtx-scientist-i-computational-biology"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/crisprtx-scientist-i-computational-biology\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fcrisprtx-scientist-i-computational-biology"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3654990}},{"tool":"search_jobs","arguments":{"company":"crisprtx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3654990},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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