{"id":1460114,"url":"https://alion.io/job/crisprtx-scientist-ii-crispr-x-gene-insertion","title":"Scientist II, CRISPR-X - Gene Insertion","company":{"id":1892348,"name":"crisprtx","domain":"crisprtx.com","url":"https://alion.io/company/crisprtx","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":75,"open_postings":3,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-28T05:59:10Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":130000,"max":140000,"currency":"USD","period":"year","gross":null,"usd_annual":140000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Cell Culture","optional":false},{"name":"CRISPR","optional":false},{"name":"Exa","optional":false},{"name":"Next-Generation Sequencing","optional":false},{"name":"qPCR","optional":false}],"status":"live","first_seen_at":"2026-09-04T00:00:00Z","employer_posted_date":"2026-09-04","last_verified_at":"2026-10-28T15:19:18Z","board_verified":true,"closed_at":null,"days_open":54,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":54},"description":"Job Description:\nCompany Overview\nFounded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogeneautotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependentbeta thalassemia. CRISPRTherapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics hasestablished strategic collaborations with leading biopharmaceutical partners, including VertexPharmaceuticals. CRISPRTherapeutics AG is headquartered in Zug, Switzerland,with its wholly-owned U.S. subsidiary, CRISPRTherapeutics, Inc., and R&D operations based in Boston, Massachusetts and SanFrancisco, California.\nPosition Summary\nAre you passionate about developing next-gen CRISPR therapies? We are seeking a highly motivated and creative Scientist II to grow our diverse, innovation-focused CRISPR-X team that pioneers novel gene editing therapies for human disease. We are part of CRISPR Therapeutics, a leading gene editing company with a broad clinical portfolio. The successful candidate will be an integral part of our team, whose aim is to research, develop and advance the next generation of genome editing modalities and genetic therapies for a wide range of human indications. The position requires enthusiasm, passion, outstanding skills in the art, attention to detail, and a desire to create new medicines for patients\nResponsibilities\nLead, design, and optimize research with the aims of exploring and developing next-generation gene editing strategies, primarily gene insertions, using CRISPR-based tools and beyond, and synthetic immunology.\nDesign, execute, and interpret research requiring molecular biology techniques including cloning, qPCR/ddPCR, NGS, RNA and DNA analysis, cell culture, and other cell-based assays.\nUse knowledge of immune cell biology to guide construct design, target selection, and interpretation of phenotypic outcomes of in-vivo CAR T and other immune studies.\nDissect published literature to find novel solutions to gene editing and immunology problems. \nDevelop a deep understanding of the biology underlying new disease indications and design translational assays and experimental strategies to enable evaluation of gene editing and CAR approaches across in vitro and in vivo systems.\nMinimum Qualifications\nPrior experience with gene editing, including experience applying and developing next generation gene editing technologies, such as recombinases, retrotransposons or other integration approaches, in an academic and/or industry setting, with a track record demonstrating significant contributions.\nHands-on experience with chimeric antigen receptor (CAR) T cell engineering, including CAR construct design, gene editing and/or transgene delivery in primary human T cells, and functional characterization of the resulting CAR-T cells.\nPh.D. in biology, bioengineering, immunology, or related discipline with 2-5+ years of professional experience, or non-PhD and 10-12+ years of progressive, relevant experience.\nOutstanding problem-solving skills and attitude to think outside the box.\nExcellent writing, reviewing, and presentation skills.\nChallenges oneself continuously to enhance scientific capabilities.\nAbility to work independently as well as collaboratively in a results-oriented research team environment.\nMust possess critical thinking and self-reliance to solve tasks independently.\nSelf-motivated and scientifically rigorous, with outstanding organization and multitasking capability.\nEntrepreneurial spirit showing resourcefulness, accountability, agility to pivot, transparency, and productivity.\nPreferred Qualifications\nPrior experience with protein and/or RNA engineering. \nPrior experience establishing next-generation CAR T cells ex-vivo and/or in-vivo CAR T cells. \nPrior experience with diverse delivery technologies, including transfection/nucleofection, lipid nanoparticles, and viral vectors/particles.\nPrior experience designing and executing in vivo studies, including downstream tissue processing.\nExperience managing and mentoring junior scientists.\nCompetencies\nCollaborative - Openness, One Team\n\nUndaunted - Fearless, Can-do attitude\n\nResults Orientation - Delivering progress toward our mission. Sense of urgency in solving problems.\n\nEntrepreneurial Spirit - Proactive. Ownership mindset.\n\nDue to the nature of their work, our manufacturing and lab-based positions are located fully on-site.\nScientist II: Base pay range of $130,000 to $140,000+ bonus, equity and benefits\nThe range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.\nCRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.\nTo view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy","description_format":"text","description_chars":5848,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Biotechnology","Health Care"],"lifecycle":[{"event":"open","at":"2026-09-29T11:54:35Z"}],"visa":[],"liveness":{"score":28,"band":"fade","label":"Fading","p_open":1,"p_active":0.616,"p_room":0.45,"age_days":54,"expected_fill_days":29,"reasons":["conf:4","win:tail"],"computed_at":"2026-10-28T05:59:10Z"},"pay":{"stated_usd_annual":140000,"is_top_pay":true},"html_url":"https://alion.io/job/crisprtx-scientist-ii-crispr-x-gene-insertion","json_url":"https://alion.io/job/crisprtx-scientist-ii-crispr-x-gene-insertion.json","meta":{"generated_at":"2026-10-28T17:25:57Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":23717,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-29T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1892348},"rest":"https://alion.io/mcp/rest/get_company?id=1892348"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fcrisprtx-scientist-ii-crispr-x-gene-insertion"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fcrisprtx-scientist-ii-crispr-x-gene-insertion"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fcrisprtx-scientist-ii-crispr-x-gene-insertion"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/crisprtx-scientist-ii-crispr-x-gene-insertion\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fcrisprtx-scientist-ii-crispr-x-gene-insertion"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1460114}},{"tool":"search_jobs","arguments":{"company":"crisprtx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1460114},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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