{"id":1460131,"url":"https://alion.io/job/crisprtx-senior-scientist-analytical-development","title":"Senior Scientist, Analytical Development","company":{"id":1892348,"name":"crisprtx","domain":"crisprtx.com","url":"https://alion.io/company/crisprtx","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":75,"open_postings":4,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-10-23T05:54:15Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":140000,"max":155000,"currency":"USD","period":"year","gross":null,"usd_annual":155000},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Cell Culture","optional":false},{"name":"CRISPR","optional":false},{"name":"Exa","optional":false},{"name":"Flow Cytometry","optional":false},{"name":"FlowJo","optional":false},{"name":"GraphPad Prism","optional":false},{"name":"JMP","optional":false},{"name":"Next-Generation Sequencing","optional":false},{"name":"PCR","optional":false}],"status":"live","first_seen_at":"2026-07-20T00:00:00Z","employer_posted_date":"2026-07-20","last_verified_at":"2026-10-22T07:02:16Z","board_verified":true,"closed_at":null,"days_open":96,"trust":{"level":"stale","repost_count":0,"flags":["stale"],"days_open":95},"description":"Job Description:\nCompany Overview\nFounded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY®(exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependentbeta thalassemia. CRISPRTherapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics hasestablished strategic collaborations with leading biopharmaceutical partners, includingVertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug,Switzerland, with its wholly-owned U.S. subsidiary, CRISPRTherapeutics, Inc., and R&D operations based in Boston, Massachusetts and SanFrancisco,California.\nJob Summary\nReporting to the Director of Analytical Development, theSenior Scientistwillberesponsiblefordevelopment, implementation, and qualification of cell-basedassays(potency, immunogenicity, etc.).The candidate will leadcell-basedanalytical technology transfers from Analytical Development to collaborators within and outside CRISPR Therapeutics.They will also authorsections of regulatory briefing packages or submissions related to technicalrole.\nResponsibilities\nLead a team responsible for the development, optimization, and technology transfer and qualification of cell-based assays for Drug Products and Drug Substances across the CRISPR portfolio, including potency assays for ex-vivo and in-vivo programs. Lead the team in qualifying andmaintainingcell lines for various potency assays.\n\nExpertise in flow cytometry-based assays required to support various cell-based testing.Lead team responsible for trending potency data andestablishingspecifications for lot release and stability studies.\n\nProvide technical and operational oversight to contract labs supporting cell-based potency tests for multiple products across the portfolio.\n\nMaintain awareness of applicable regulatory guidelines inareaof expertise, including but not limited to guidelines from ICH, USP, EP, and JP.\n\nMinimum Qualifications\nPh.D. in Biology, Chemistry, ChemicalEngineeringor related discipline with4 -8+years ofpost-PhDrelevant industry experience, or non-PhD with 12-15 years of relevant experience.\n\nProficient in mammalian cell culture, flow cytometry, droplet digital PCR, sanger sequencing, and amplicon next generation sequencing platforms.\n\nProficient in statisticalanalysessoftware, including JMP,GraphPAD,Qubas,Softmax,FlowJo,MACSQuantify.\n\nProficient in parallel line analysis for interpretation of potency data.\n\nExpertiseapplied to both ex-vivo and in-vivo cell and gene therapy platforms.\n\nExperience in leading assay lifecycle management for Cell and Gene Therapy products is strongly desired.\n\nPreferred Qualifications\nAbility to mentor a team of scientistsinto increasingresponsibility.\n\nExperience with authoring regulatory submission documents.\n\nExperience with leading analytical method transfer and supporting process technology transfer.\n\nAwareness of regulatory guidelines in FDA and EMA guidance documents, CFR, ICH, USP, and Ph. Eur.\n\nProficient in risk assessments to support comparability assessments, process and method changes, andestablishdrug product critical quality attributes.\n\nAbility to work in cross functional teams supporting product development and tech transfers.\n\nCompetencies\nCollaborative - Openness, One Team\n\nUndaunted - Fearless, Can-do attitude\n\nResults Orientation - Delivering progress toward our mission.Senseof urgency in solving problems.\n\nEntrepreneurial Spirit - Proactive. Ownership mindset.\n\nDue to the nature of their work, our manufacturing and lab-based positions are located fully on-site.\nSenior Scientist, Analytical Development: Base pay range of $140,000 to $155,000+ bonus, equity and benefits\nThe range provided is CRISPR Therapeutics’ reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.\nCRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.\nTo view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy","description_format":"text","description_chars":5051,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Health Care","Cell & Gene Therapy"],"lifecycle":[{"event":"open","at":"2026-09-29T11:54:35Z"}],"visa":[],"liveness":{"score":13,"band":"cold","label":"Long shot","p_open":1,"p_active":0.47,"p_room":0.28,"age_days":95,"expected_fill_days":36,"reasons":["conf:22","win:tail","crowd:"],"computed_at":"2026-10-23T05:54:15Z"},"pay":{"stated_usd_annual":155000,"is_top_pay":false},"html_url":"https://alion.io/job/crisprtx-senior-scientist-analytical-development","json_url":"https://alion.io/job/crisprtx-senior-scientist-analytical-development.json","meta":{"generated_at":"2026-10-24T03:55:10Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":6154,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-25T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1892348},"rest":"https://alion.io/mcp/rest/get_company?id=1892348"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fcrisprtx-senior-scientist-analytical-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fcrisprtx-senior-scientist-analytical-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fcrisprtx-senior-scientist-analytical-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/crisprtx-senior-scientist-analytical-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fcrisprtx-senior-scientist-analytical-development"}]}