{"id":3340818,"url":"https://alion.io/job/dayhoff-labs-research-scientist-computational-enzymology","title":"Research Scientist, Computational Enzymology","company":{"id":4403902,"name":"Dayhoff Labs","domain":"dayhofflabs.com","url":"https://alion.io/company/dayhoff-labs","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"B","score":75,"open_postings":6,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":null,"computed_at":"2026-11-05T05:54:30Z"}},"role":"AI/ML","role_family":"AI/ML","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States","London, United Kingdom"],"countries":["US","GB"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":132000,"max_usd":293000,"period":"year","method":"role_country_seniority_unknown","sample_n":4425},"experience_years_min":null,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-08-14T13:20:24Z","employer_posted_date":"2026-08-14","last_verified_at":"2026-11-06T03:50:01Z","board_verified":true,"closed_at":null,"days_open":83,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":83},"description":"About us\nWe're reverse-engineering the origin of life - one of the great unsolved problems in science, and one we think AI finally makes tractable. Understanding this transition, from geochemistry to biochemistry, is what will let us orchestrate molecular networks and build systems that are more capable, adaptive, and efficient.\nIf we succeed, the applications are vast: catalysis, green synthesis, ab initio synthetic biology, programmable matter. Understanding and harnessing these processes could let ten billion of us thrive on this planet - and let life keep evolving beyond it.\nWe're a small, diverse team of AI engineers, computational scientists, and bench scientists. We hold ourselves to the rigor of a research institute, but we ship like an engineering firm. Global team, HQs in Cambridge, MA and London, UK.\nThe role\nYou'll simulate enzyme-catalysed reactions from the physics up. Using reactive and free-energy methods you'll map how reactions proceed in the active site, compute transition states and barriers, and work out where the catalysis actually comes from: why a step has the barrier it does, which residues do the work, and how mutations move it. You'll work with the wider simulation and ML teams, but also directly with our bench scientists - seeing your predictions tested in vitro and getting experimental feedback on fast, tight loops.\nWhat you'll do\nCharacterise mechanisms, transition states, and activation barriers in the active site, and compare computed barriers against measured kinetics\n\nPin down the origins of catalysis - the residues, interactions, and dynamics that set rate and selectivity - and use MD to understand how active-site motion shapes the reaction\n\nTurn results into concrete, testable proposals for the wet lab, and fold the resulting data back into your models\n\nHelp physics-based and learned methods strengthen each other as we build them out\n\nEssential experience.\nExpertise in enzymatic reaction modelling using QM/MM and a variety of free energy methods\n\nA solid grasp of enzyme catalysis: mechanism, kinetics, cofactors, and how active-site chemistry and conformational dynamics sets rate and selectivity\n\nSound judgement about method selection, good understanding o methodological limitations and computational cost\n\nHighly preferred\nExperience in protein design for enzymatic optimization\n\nYou've run design-test-refine cycles with a wet lab before\n\nExperience with reactive machine-learned potentials, or coupling physics-based modelling with ML\n\nLogistics\nCompensation is highly competitive. We're also able to sponsor visas for the right candidate.","description_format":"text","description_chars":2616,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Artificial Intelligence","AI for Science"],"lifecycle":[{"event":"open","at":"2026-10-27T15:25:28Z"}],"visa":[],"liveness":{"score":10,"band":"cold","label":"Long shot","p_open":1,"p_active":0.356,"p_room":0.28,"age_days":82,"expected_fill_days":30,"reasons":["conf:3","win:tail","crowd:"],"computed_at":"2026-11-05T05:54:30Z"},"pay":null,"html_url":"https://alion.io/job/dayhoff-labs-research-scientist-computational-enzymology","json_url":"https://alion.io/job/dayhoff-labs-research-scientist-computational-enzymology.json","meta":{"generated_at":"2026-11-06T05:41:26Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":10007,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-07T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4403902},"rest":"https://alion.io/mcp/rest/get_company?id=4403902"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fdayhoff-labs-research-scientist-computational-enzymology"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fdayhoff-labs-research-scientist-computational-enzymology"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fdayhoff-labs-research-scientist-computational-enzymology"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/dayhoff-labs-research-scientist-computational-enzymology\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fdayhoff-labs-research-scientist-computational-enzymology"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3340818}},{"tool":"search_jobs","arguments":{"company":"dayhofflabs.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3340818},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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