{"id":4205776,"url":"https://alion.io/job/egenesis-principal-research-associate-analytical-development","title":"Principal Research Associate, Analytical Development","company":{"id":5997,"name":"eGenesis","domain":"egenesis.com","url":"https://alion.io/company/egenesis","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"A","score":94,"open_postings":9,"ghost_share":0,"stale_share":0.222,"repost_share":0,"time_to_fill_p50_days":57,"computed_at":"2026-11-12T10:38:37Z"}},"role":"Biotech","role_family":"Biotech","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":103700,"max":122000,"currency":"USD","period":"year","gross":null,"usd_annual":122000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Cell Culture","optional":false},{"name":"ELISA","optional":false},{"name":"Flow Cytometry","optional":false},{"name":"qPCR","optional":false}],"status":"live","first_seen_at":"2026-11-12T16:19:44Z","employer_posted_date":"2026-11-12","last_verified_at":"2026-11-12T23:35:11Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"POSITION SUMMARY\nWe are seeking a highly motivated Principal Research Associate to join the Analytical Development team. This is an opportunity to develop analytical methods supporting gene-edited xenotransplantation products in a dynamic environment focused on molecular and cellular engineering.\nIn this role, you will independently develop analytical assays from initial concept and feasibility through optimization, qualification, and transfer. Responsibilities include assessing transgene expression and biological function in genetically modified porcine cells, with a particular emphasis on developing robust, mechanism-relevant potency assays. The successful candidate will be expected to select appropriate assay formats and biological readouts, establish controls, understand critical assay variables, and solve complex development challenges with limited supervision.\nThe position involves significant hands-on cell culture, including the isolation, growth, and maintenance of porcine primary cells. Methods may include cell-based functional assays, flow cytometry, ELISA, and real-time PCR. 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