{"id":3496783,"url":"https://alion.io/job/exelixis-senior-scientist-ii-2","title":"Senior Scientist II","company":{"id":1917987,"name":"Exelixis","domain":"exelixis.com","url":"https://alion.io/company/exelixis-com","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Alameda, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":149000,"max":188000,"currency":"USD","period":"year","gross":null,"usd_annual":188000},"salary_estimate":null,"experience_years_min":9,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-10-29T00:00:00Z","employer_posted_date":"2026-10-29","last_verified_at":"2026-11-04T23:24:19Z","board_verified":true,"closed_at":null,"days_open":7,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":7},"description":"SUMMARY: We are seeking a Senior Scientist II in Computational Chemistry to join our small-molecule discovery organization. The successful candidate will apply physics-based molecular modeling, cheminformatics, and data-driven methods to advance drug discovery programs. This role is designed for a scientist with a strong foundation in computational chemistry and a particular interest in connecting molecular simulation with cheminformatics, workflow automation, and practical machine learning. The individual will contribute to molecular dynamics, free-energy calculations, structure-based design, and compound prioritization while developing reliable computational and machine learning workflows that increase the impact of predictive methods across discovery portfolio. Strong scientific judgment, programming ability, communication, and collaboration skills are essential. The successful candidate will work closely with medicinal chemists, structural biologists, biologists, pharmacologists, and bioinformatics scientists in a fast-paced, interdisciplinary research environment.\nESSENTIAL DUTIES AND RESPONSIBILITIES:\nApply ligand- and structure-based computational methods to support small-molecule discovery programs.\nPlan, execute, analyze, and communicate molecular dynamics simulations and free-energy calculations for compound prioritization and molecular design.\nApply molecular docking, protein-ligand interaction analysis, conformational analysis, similarity searching, and other computational approaches to generate experimentally testable design hypotheses.\nUse cheminformatics methods to analyze compound collections, explore structure-activity relationships, assess chemical diversity, and support virtual library design and prioritization.\nEvaluate and apply appropriate machine-learning methods for molecular property or activity prediction, in combination with physics-based modeling and experimental data.\nAssess machine-learning model performance and applicability using scientifically appropriate validation methods, and clearly communicate limitations and uncertainty. Apply and develop cheminformatics and machine learning models to enable predictive analytics across the pipeline\nContribute to virtual screening campaigns using structure-based, ligand-based, and fragment-based approaches.\nIntegrate computational results into collaborative discovery platforms and project workflows, including tools such as LiveDesign and Spotfire.\nCollaborate closely with medicinal chemists, structural biologists, biologists, pharmacologists, and other project stakeholders to interpret data and influence compound-design decisions.\nPresent computational analyses, recommendations, assumptions, and uncertainties clearly to scientific project teams.\nStay current with emerging methods in molecular simulation, free-energy calculations, cheminformatics, machine learning, and computer-aided drug design.\nContribute to the continued development of computational chemistry capabilities and a predict-first culture within the discovery organization.\nEDUCATION & EXPERIENCE:\nBachelor’s degree in related discipline and a minimum of 9 years of relevant experience; or,\nMaster’s degree in related discipline and a minimum of 7 years of relevant experience; or,\nPhD in Computational Chemistry, Cheminformatics or related discipline, with at least 2 years of relevant experience in the biotechnology or pharmaceutical industry; or,\nEquivalent combination of education and experience.\nKNOWLEDGE & SKILLS:\nStrong foundation in molecular modeling and the physical principles governing protein-ligand interactions. Hands-on experience with one or more structure-based drug-design methods, such as molecular docking, molecular dynamics, free-energy calculations, conformational analysis, or protein-ligand interaction analysis.\nProficiency in Python for scientific computing, data analysis, or computational workflow development.\nWorking knowledge of cheminformatics concepts, such as molecular representations, fingerprints, molecular descriptors, similarity searching, substructure searching, clustering, or compound-library analysis.\nFamiliarity with open-source cheminformatics or molecular-modeling tools, such as RDKit, OpenMM, GROMACS, AMBER, or comparable platforms.\nAbility to analyze computational and experimental data critically and translate results into clear, testable molecular-design hypotheses. Understanding of structure-activity relationships and the physicochemical characteristics relevant to small-molecule drug discovery.\nStrong written, oral, and presentation communication skills. Ability to work effectively in cross-functional teams and communicate computational findings to scientists from different technical backgrounds.\nScientific curiosity and willingness to learn new methods as program needs and technologies evolve.\nADDITIONAL SKILLS & ABILITIES:\nStrategic thinker with a passion for applying computational & ML approaches to solve practical problems in drug discovery\nCollaborative team player, able to work seamlessly across disciplines\nProactive, innovative, and adaptable in a fast-paced environment\nStrong balance of technical depth and project impact orientation\nStrong written, oral, and presentation communication skills\nLocation: Alameda, CA\n\nRange for this position: $149,000 - $188,000\n\nThe base pay offered will take into account job-related knowledge, skills, experience and internal equity, among other factors.In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.\nIf you have a disability and need an accommodation in relation to the recruiting process, please email us at: .\nWORKING CONDITIONS:\nOur office is a modern space that fosters collaboration and creativity. Teams work closely together, sharing ideas and solutions in a supportive atmosphere. We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable workspace.\nDISCLAIMER:\nThe preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.\nWe are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.","description_format":"text","description_chars":7237,"description_truncated":false,"requirements":{"experience_years_min":9,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Oncology Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-30T01:41:16Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 33 · green card filings: 10","filings_12m":33,"filings_prev_12m":37,"green_card_filings_12m":10,"median_offered_wage_usd":192733,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.902,"p_room":1,"age_days":6,"expected_fill_days":20,"reasons":["conf:2","velocity","win:early"],"computed_at":"2026-11-04T06:34:25Z"},"pay":{"stated_usd_annual":188000,"is_top_pay":true},"html_url":"https://alion.io/job/exelixis-senior-scientist-ii-2","json_url":"https://alion.io/job/exelixis-senior-scientist-ii-2.json","meta":{"generated_at":"2026-11-05T01:40:29Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":2172,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-06T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1917987},"rest":"https://alion.io/mcp/rest/get_company?id=1917987"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fexelixis-senior-scientist-ii-2"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fexelixis-senior-scientist-ii-2"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fexelixis-senior-scientist-ii-2"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/exelixis-senior-scientist-ii-2\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fexelixis-senior-scientist-ii-2"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3496783}},{"tool":"search_jobs","arguments":{"company":"exelixis.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3496783},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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