{"id":3413845,"url":"https://alion.io/job/flagship-pioneering-principal-data-engineer","title":"Principal Data Engineer","company":{"id":8393,"name":"Flagship Pioneering","domain":"flagshippioneering.com","url":"https://alion.io/company/flagshippioneering","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":true,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":79,"open_postings":9,"ghost_share":0,"stale_share":0.778,"repost_share":0.111,"time_to_fill_p50_days":51,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Data Science","role_family":"Data Science","seniority":"lead","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":179000,"max":236000,"currency":"USD","period":"year","gross":null,"usd_annual":236000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Amazon EC2","optional":false},{"name":"Amazon S3","optional":false},{"name":"AWS","optional":false},{"name":"AWS Lambda","optional":false},{"name":"AWS Step Functions","optional":false},{"name":"CI/CD","optional":false},{"name":"CloudFormation","optional":false},{"name":"IAM","optional":false},{"name":"Python","optional":false},{"name":"Spark","optional":false},{"name":"SQL","optional":false},{"name":"Amazon SageMaker","optional":true},{"name":"Databricks","optional":true},{"name":"Feature Store","optional":true},{"name":"LLM","optional":true},{"name":"MLFlow","optional":true},{"name":"Model Context Protocol","optional":true},{"name":"Snowflake","optional":true}],"status":"live","first_seen_at":"2026-10-27T19:25:17Z","employer_posted_date":"2026-10-28","last_verified_at":"2026-10-30T09:34:25Z","board_verified":true,"closed_at":null,"days_open":2,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":2},"description":"What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients by helping scale the programmable infrastructure behind a new human cellular biology platform?\nAbout Vesalius\nVesalius Therapeutics is pioneering a new platform to generate breakthrough treatments for common diseases. Our platform combines large-scale human genetics, genomics, stem cell studies, high-dimensional cellular phenotyping, and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Vesalius was founded in 2019 by Flagship Pioneering.\nRole Overview\nWe are seeking a Principal Data Engineer to lead the architecture and evolution of the data platform underpinning our human genetics, multi-omics, and high-content imaging programs.\nThis is a senior, hands-on leadership role with broad technical authority. As the architectural lead for data engineering, you will set the direction for our AWS environment and the pipelines, catalog, and access layers built on it, defining the technical roadmap and the standards others build against. The scope spans core cloud data engineering (orchestration, warehousing, infrastructure as code, cost governance) and the distinctive challenges of scientific data: connecting each microscopy image to its cell line, donor, and study of origin, and enabling scientists to answer genotype questions directly, without specialist intervention.\nYou will join a focused, high-impact team supporting a research organization whose data generation and analytical ambitions are expanding rapidly. Our platform is established and productive, and is now entering a deliberate modernization phase. You will lead that transition, with significant influence over the platform's next-generation architecture.\nAt Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.\nRole Responsabilities\nServe as technical owner and architect of our AWS environment, including account structure, IAM, networking, compute, and storage.\nLead and extend cost governance, including budgets, alerting, tagging enforcement, rightsizing, and storage lifecycle and tiering.\nDefine and own developer operations for the data platform, including infrastructure as code, CI/CD, container builds, and secrets and environment management.\nUpgrade our data lake, managed orchestration, metadata and data ingestion workflows to scale with future data production and enhance the infrastructure that transfers data from the lab to the cloud.\nPartner with ML and computational biology leaders to define the interface between platform and modelling.\nRequired Qualifications\n10+ years building and operating production data infrastructure, with a track record of architecting and owning platforms end to end.\nDeep AWS expertise: S3, IAM, EC2, Batch, Lambda, and Spark (EMR or equivalent). Experience as technical owner of production cloud environments, including multi-account architecture and cross-account access.\nStrong Python and SQL, with a background in production-grade pipeline development.\nProduction experience with workflow orchestration (Nextflow, Airflow, Temporal, Step Functions, Redun, or similar) and the judgement to evaluate and select among them.\nInfrastructure as code (CloudFormation/CDK), CI/CD, containers, and observability. DevOps is a core competency for this role.\nData modelling and warehouse or lakehouse design, including metadata management, lineage, and data quality practice.\nCost governance at scale, including budgets, tagging, rightsizing, and storage lifecycle across hundreds of terabytes.\nFluency with scientific data semantics (studies, samples, donors, cell lines, assays) and the ability to partner directly with scientists to translate their questions into data models.\nPreferred Qualifications\nFamiliarity with genetics and genomics data.\nMicroscopy or high-content screening data, including large binary object stores, transfer optimization, and image streaming for model training.\nDatabricks, OpenMetadata, or a comparable catalog in production.\nSnowflake, particularly governed access patterns over cloud object storage.\nML infrastructure: SageMaker or Databricks ML, MLflow or Weights & Biases, feature stores.\nServing data to LLM or agent clients (MCP servers, tool APIs).\nExperience leading data platform architecture as a senior or principal individual contributor, ideally in biotech, pharma R&D, or a research institute.\nWe are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.\nWe recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your backgroundand interest in Flagship.\nRecruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.\nPrivacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact . \nThe salary range for this role is $179,000 - $236,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Vesalius Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Vesalius Therapeutics's good faith estimate as of the date of publication and may be modified in the future.\nPrivacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact .","description_format":"text","description_chars":7942,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Venture Capital"],"lifecycle":[{"event":"open","at":"2026-10-28T18:42:20Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 10 · green card filings: 2","filings_12m":10,"filings_prev_12m":3,"green_card_filings_12m":2,"median_offered_wage_usd":150833,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":2,"expected_fill_days":51,"reasons":["conf:0","velocity","win:early"],"computed_at":"2026-10-30T05:48:23Z"},"pay":{"stated_usd_annual":236000,"is_top_pay":true},"html_url":"https://alion.io/job/flagship-pioneering-principal-data-engineer","json_url":"https://alion.io/job/flagship-pioneering-principal-data-engineer.json","meta":{"generated_at":"2026-10-30T11:14:01Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":16107,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":8393},"rest":"https://alion.io/mcp/rest/get_company?id=8393"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fflagship-pioneering-principal-data-engineer"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fflagship-pioneering-principal-data-engineer"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fflagship-pioneering-principal-data-engineer"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/flagship-pioneering-principal-data-engineer\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fflagship-pioneering-principal-data-engineer"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3413845}},{"tool":"search_jobs","arguments":{"company":"flagshippioneering.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3413845},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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