{"id":2037940,"url":"https://alion.io/job/flagship-pioneering-senior-scientist-bioanalytical-sciences","title":"Senior Scientist, Bioanalytical Sciences","company":{"id":8393,"name":"Flagship Pioneering","domain":"flagshippioneering.com","url":"https://alion.io/company/flagshippioneering","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":true,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":84,"open_postings":9,"ghost_share":0,"stale_share":0.444,"repost_share":0,"time_to_fill_p50_days":62,"computed_at":"2026-10-21T05:46:15Z"}},"role":"Biotech","role_family":"Biotech","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":126000,"max":181500,"currency":"USD","period":"year","gross":null,"usd_annual":181500},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"ELISA","optional":false},{"name":"Flow Cytometry","optional":false}],"status":"live","first_seen_at":"2026-10-07T16:14:47Z","employer_posted_date":"2026-10-07","last_verified_at":"2026-10-22T03:40:14Z","board_verified":true,"closed_at":null,"days_open":14,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":14},"description":"Company Summary:\nSerif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.\nSerif was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.\nPosition Summary:\nSenior Scientist, Bioanalytical Sciences (Innate Immunity, Ligand Binding Assays & Flow Cytometry)\nWe are seeking a highly motivated and accomplished Sr. Scientist I with deep expertise in innate immunogenicity, and bioanalytical assay development, including ligand binding assays (LBA) and multi-color flow cytometry. This full-time, laboratory-based position calls for hands-on mastery of bioanalytical platforms and a strong working knowledge of LNP-formulated and nucleic acid therapeutics, including biodistribution studies. In this role, you will lead the development, qualification, and implementation of various immunogenicity and LBAs that support both our platform and therapeutic programs, with a particular focus on characterizing innate immune responses to novel nucleic acid modalities. You will also mentor, coach, and manage junior scientists, setting scientific directions, guiding experimental design, and fostering technical growth within the team. You will thrive in a dynamic, fast-paced, entrepreneurial environment and contribute as part of a highly collaborative, cross-functional team.\nKey Responsibilities: \nDesign, develop and execute cell-based immunoassays, flow cytometry based assays and LBAs to assess immunogenicity to LNP delivered nucleic acid cargoes in vitro and in vivo\nApply knowledge of innate immunology and establish in vitro screening assays for various nucleic acid modalities and establish criteria for release of cargo for pre-clinical research\nCollaborate closely with CMC, molecular biology and cell biology teams to screen nucleic acid cargoes (immunogenicity assessment etc.) and ensure timely delivery of high-quality data and summarize results\nEnsure development, qualification, and validation of bioanalytical assays in compliance with applicable guidelines\nDesign, optimize, and execute biodistribution studies (flow cytometry and histological techniques) for LNP/nucleic acid therapies\nDesign, establish and execute assays for assessing various in vivo immunogenicity predictors for LNP/nucleic acid therapies including but not limited to biomarkers, cytokines, complement activation and anti-drug antibodies (ADA) in rodents and NHPs\nDesign, develop, optimize, and execute bioanalytical assays to support nonclinical studies, including PK, PD, biomarker, and immunogenicity endpoints\nExecute test procedures such as sample extraction and measurement by Flow Cytometry, ELISA, MSD, Luminex, bDNA, ddPCR and perform data interpretation\nAnalyze and summarize scientific data and maintain timely documentation and completion of electronic lab notebooks in compliance with industry guidelines\nPresent at project team meetings and to relevant stakeholders\nMentor, coach, and manage junior scientists\nQualifications: \nPh.D. in immunology, biochemistry, pharmaceutical sciences, cell biology or related field with 5 plus years of industry experience\nDemonstrated expertise in innate immune signaling and nucleic acid sensing pathways for DNA and mRNA\nProficiency in multicolor flow cytometry, ddPCR, ligand binding assays, leukopak processing and isolation of PBMCs\nExperience with LNPs, and nucleic acid modalities preferred\nExperience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes\nExperience managing junior scientists\nStrong communication, presentation and interpersonal skills\nAttention to detail, strategic thinking, problem solving, and decision-making skills\nMore About Flagship Pioneering\nWe are creative optimists and we would love for you to consider joining our team! See all our open opportunities across Flagship Pioneering’s Ecosystem!\nFlagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including: Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).\nWe believe pioneering is best done by teams, and that it is a process that can be taught, learned, and replicated. Learn more about our Company Creation Model.\nCan Breakthrough Innovations Be Made Systematically? A Conversation With Noubar Afeyan, Flagship Pioneering’s CEO.\nFlagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.\nRecruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.\nPrivacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact . \nThe salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.\nPrivacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact .","description_format":"text","description_chars":8845,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Venture Capital","Vaccines"],"lifecycle":[{"event":"open","at":"2026-10-07T16:50:28Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 10 · green card filings: 2","filings_12m":10,"filings_prev_12m":3,"green_card_filings_12m":2,"median_offered_wage_usd":150833,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":13,"expected_fill_days":62,"reasons":["conf:0","velocity","win:early"],"computed_at":"2026-10-21T05:46:15Z"},"pay":{"stated_usd_annual":181500,"is_top_pay":false},"html_url":"https://alion.io/job/flagship-pioneering-senior-scientist-bioanalytical-sciences","json_url":"https://alion.io/job/flagship-pioneering-senior-scientist-bioanalytical-sciences.json","meta":{"generated_at":"2026-10-22T04:31:26Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":4931,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-23T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":8393},"rest":"https://alion.io/mcp/rest/get_company?id=8393"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fflagship-pioneering-senior-scientist-bioanalytical-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fflagship-pioneering-senior-scientist-bioanalytical-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fflagship-pioneering-senior-scientist-bioanalytical-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/flagship-pioneering-senior-scientist-bioanalytical-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fflagship-pioneering-senior-scientist-bioanalytical-sciences"}]}