{"id":1330127,"url":"https://alion.io/job/frontage-laboratories-inc-principal-scientist","title":"Principal Scientist","company":{"id":3783210,"name":"Frontage Laboratories","domain":"frontagelab.com.cn","url":"https://alion.io/company/frontagelab","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"ADP","truth_index":{"grade":"C","score":66,"open_postings":65,"ghost_share":0.477,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":90,"computed_at":"2026-10-20T05:45:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Exton, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":61000,"max_usd":162000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":584},"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-07-31T14:24:00Z","employer_posted_date":"2026-07-31","last_verified_at":"2026-10-20T17:35:24Z","board_verified":true,"closed_at":null,"days_open":81,"trust":{"level":"ok","repost_count":0,"flags":["company_stale"],"days_open":80},"description":"In vitro ADME Senior/Principal Scientist - DMPK\nLocation: Exton, PA\nDepartment: DMPK (Drug Metabolism & Pharmacokinetics)\nEmployment Type: Full-Time\nCompany\nFrontage Laboratories Inc. is an award winning, publicly listed, full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada, and China, growing significant YoY growth. Our core competencies include pre-clinical, drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.\nPosition Summary\nFrontage Laboratories is seeking an experienced and highly motivated Senior/Principal Scientist to join our In Vitro ADME group. This is a laboratory-based position responsible for the development, execution, interpretation, and reporting of a broad range of in vitro ADME studies supporting drug discovery and IND-enabling programs.\nRoles & Responsibilities\nDesign, perform, troubleshoot, and interpret a broad range of in vitro ADME studies including metabolic stability, CYP inhibition, time-dependent inhibition (TDI), CYP induction, reaction phenotyping, enzyme kinetics, plasma protein binding, blood-to-plasma partitioning, tissue binding, using LC-MS/MS-based analytical methods.\nIndependently conduct routine and complex ADME assays while ensuring high-quality data generation and timely project completion.\nPerform sample preparation, LC-MS/MS analysis, data processing, and result interpretation.\nPrepare study protocols, technical reports, and scientific summaries.\nTroubleshoot experimental and analytical challenges and implement appropriate solutions.\nMaintain laboratory instruments and ensure compliance with SOPs, quality standards, and laboratory safety requirements.\nSupport client discussions by providing scientific expertise in study design and data interpretation.\nEducation & Requirements\nPh.D. or MS degree in Pharmaceutical Sciences, Analytical Chemistry, Biochemistry, Pharmacology, or related discipline with more than 5 years of relevant industry experience,\nStrong hands-on experience with multiple in vitro ADME assays.\nExtensive experience with LC-MS/MS-based quantitative bioanalysis is preferred.\nStrong troubleshooting and laboratory problem-solving skills.\nGood written and verbal communication skills.\nAbility to manage multiple studies in a fast-paced CRO environment.\nSalary and Benefits:\nFrontage Laboratories offers a competitive compensation and generous benefits package including health and dental insurance, a 401(k) plan, health insurance, short and long-term disability insurance, life insurance etc.\nFrontage Laboratories Inc. is an equal opportunity employer. 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