{"id":3237047,"url":"https://alion.io/job/genentech-senior-principal-scientist-pathologist","title":"Senior Principal Scientist, Pathologist","company":{"id":1757810,"name":"Genentech","domain":"gene.com","url":"https://alion.io/company/gene-com","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":80,"open_postings":25,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":21,"computed_at":"2026-10-30T05:48:23Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":198900,"max":369300,"currency":"USD","period":"year","gross":null,"usd_annual":369300},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"GLP","optional":false}],"status":"live","first_seen_at":"2026-10-16T00:00:00Z","employer_posted_date":"2026-10-16","last_verified_at":"2026-10-30T05:08:10Z","board_verified":true,"closed_at":null,"days_open":14,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":14},"description":"We advance science so that we all have more time with the people we love.\nTranslational Safety Pathologists provide scientific leadership across drug development, from early research through clinical development and marketed products. This Senior Principal (SE8) role is intended for an experienced toxicologic pathologist who can immediately assume independent pathology and safety leadership for multiple fast-moving development programs, including programs involving novel modalities and novel, accelerated, or otherwise nontraditional regulatory strategies. The successful candidate will integrate pathology, toxicology, pharmacology, translational, and clinical information to identify and contextualize risk, shape development strategy, and enable timely, high-quality decisions.\nThe role combines hands-on pathologic evaluation with broad drug-development pathology leadership. The Senior Principal Pathologist-Scientist is expected to operate with a high degree of autonomy, influence cross-functional teams and senior decision makers, and contribute visibly to the scientific and strategic direction of Translational Safety Pathology.\nOpportunity:\nAs an integral member of our dynamic team, you will:\nServe as lead/project pathologist for multiple complex development programs and provide independent pathology strategy from discovery and candidate selection through regulatory milestones and later-stage development, as needed.\nProvide expert veterinary, clinical, technical, and scientific input for studies, including necropsy, clinical pathology and histopathology interpretation, pathology peer review, and integrated assessment of study findings.\nPartner closely with toxicologists, study operations professionals, translational scientists, pharmacologists, clinicians, and regulatory colleagues to design fit-for-purpose GLP and non-GLP safety programs that answer key development questions efficiently.\nRapidly synthesize complex or incomplete datasets, leverage the external literature, and develop clear best-evidence positions that support risk assessment, dose selection, study design, and program decisions.\nAnticipate potential target-, modality-, or mechanism-related safety issues and design or lead investigative and mechanistic studies to resolve uncertainty and inform development strategy.\nContribute to and, where appropriate, lead the development of safety biomarkers, diagnostics, digital/computational pathology approaches, and new approach methodologies (NAMs) that strengthen translation and decision making.\nIdentify opportunities to refine study design and reduce or replace animal use where scientifically appropriate, while maintaining robust safety assessment and regulatory readiness.\nAuthor or critically review regulatory documents and presentations; represent Translational Safety and Genentech/Roche in interactions with health authorities and support programs using novel, accelerated, or otherwise nontraditional regulatory strategies.\nProvide proactive, high-impact scientific and strategic pathology leadership beyond assigned programs, including leadership of cross-functional initiatives, therapeutic-area or expert working groups, and functional capability-building efforts.\nMentor pathologists and other scientists, promote rigorous and pragmatic scientific decision making, and contribute to an inclusive, collaborative, high-performing team culture.\nAdvance the external scientific standing of Genentech/Roche through high-quality publications, presentations, scientific collaborations, and participation in relevant professional or industry forums.\nWho You Are:\nDVM/VMD or equivalent veterinary degree and board certification by the American College of Veterinary Pathology (ACVP), European College of Veterinary Pathologists (ECVP), or equivalent recognized board with 5+ years of direct drug-development experience in the pharmaceutical or biotechnology industry, with sufficient breadth and depth to independently support active programs from the time of hire.\nDemonstrated ability to independently support and influence drug-development programs as a toxicologic pathologist, including interpretation of nonclinical safety data in a broader translational and regulatory context.\nA track record of effective cross-functional leadership and sound, risk-based decision making in situations with ambiguity, incomplete data, compressed timelines, or competing program priorities.\nStrong knowledge of toxicologic pathology, nonclinical safety assessment, and the principles that underpin regulatory toxicology and drug-development strategy.\nRecognized expertise and a demonstrated record of scientific leadership in at least one area relevant to translational safety, toxicologic pathology, or drug development.\nExcellent written and verbal communication skills, including the ability to communicate complex pathology and safety issues clearly to project teams, senior leaders, and regulatory audiences.\nAbility and willingness to work on-site in South San Francisco at least 3 days per week.\nPreferred Qualifications and Experience\nPhD or equivalent advanced research training/experience in pathology or a related biomedical discipline.\nExperience with, or strong scientific interest in, novel therapeutic modalities and the unique safety-assessment challenges they create.\nExperience developing or applying NAMs, organotypic/in vitro models, computational or digital pathology approaches, or other innovative tools that improve human relevance and/or reduce animal use.\nDemonstrated commitment to animal welfare and the 3Rs (replacement, reduction, and refinement) in nonclinical development.\nDrug-development experience working across therapeutic areas/ disease indications.\nDirect experience with health-authority interactions, novel development pathways, or regulatory strategies that require a high degree of scientific judgment and integration.\nEvidence of scientific thought leadership through influential internal contributions, publications, presentations, professional society activity, or other recognized contributions to the field.\nPlease note: This is not a fully remote position. Regular on-site presence in South San Francisco is an essential expectation of the role.\nRelocation benefits are not available for this posting.\nThe expected salary range for this position based on the primary location of California is $198,900- $369,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.\nBenefits\nGenentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.\nIf you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.","description_format":"text","description_chars":7337,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":true,"industries":["Biotechnology","Health Care","Care Coordination & Population Health"],"lifecycle":[{"event":"open","at":"2026-10-25T12:44:42Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 188 · green card filings: 34","filings_12m":188,"filings_prev_12m":151,"green_card_filings_12m":34,"median_offered_wage_usd":150788,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":53,"band":"ok","label":"Likely open","p_open":1,"p_active":0.59,"p_room":0.9,"age_days":14,"expected_fill_days":21,"reasons":["conf:0","stale_co","velocity","win:mid","comp:brand"],"computed_at":"2026-10-30T05:48:23Z"},"pay":{"stated_usd_annual":369300,"is_top_pay":true},"html_url":"https://alion.io/job/genentech-senior-principal-scientist-pathologist","json_url":"https://alion.io/job/genentech-senior-principal-scientist-pathologist.json","meta":{"generated_at":"2026-10-30T06:21:14Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":8786,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1757810},"rest":"https://alion.io/mcp/rest/get_company?id=1757810"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fgenentech-senior-principal-scientist-pathologist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fgenentech-senior-principal-scientist-pathologist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fgenentech-senior-principal-scientist-pathologist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/genentech-senior-principal-scientist-pathologist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fgenentech-senior-principal-scientist-pathologist"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3237047}},{"tool":"search_jobs","arguments":{"company":"gene.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3237047},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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