{"id":765053,"url":"https://alion.io/job/genezenlabs-manufacturing-supervisor-upstream","title":"Manufacturing Supervisor, Upstream","company":{"id":719970,"name":"Genezen","domain":"genezen.com","url":"https://alion.io/company/genezen","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":94,"open_postings":4,"ghost_share":0,"stale_share":0.25,"repost_share":0,"time_to_fill_p50_days":46,"computed_at":"2026-10-28T05:59:10Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"middle","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"explicit","locations":["Indianapolis, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":66000,"max_usd":120000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":4330},"experience_years_min":4,"visa_sponsorship":true,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Bioreactors","optional":false},{"name":"CAPA","optional":false},{"name":"Cell Culture","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-08-20T19:25:41Z","employer_posted_date":"2026-10-22","last_verified_at":"2026-10-28T05:16:52Z","board_verified":true,"closed_at":null,"days_open":68,"trust":{"level":"ok","repost_count":1,"flags":[],"days_open":68},"description":"The field of gene therapy is growing rapidly and Genezen is here to meet the exacting needs of our clients. We provide process development, produce GMP viral vectors, and provide cell transduction for gene and cell therapy clinical trials and are proud to be a part of the process that leads to new cures. \nWORKING AT GENEZEN\nMany people have worked in environments where you feel like just another nameless part of an enormous machine. Genezen is different. We want our employees to be innovative, collaborative problem solvers who are dedicated to meeting the challenges of working at a fast-growing company. We are dedicated to empowering our employees to be their best and making Genezen a rewarding place to work. Every employee contributes to the success of the company and you can be part of that team.\nJOB SUMMARY\nPromote a safe working environment, training, and development of the manufacturing team; plan on-time execution of batch activities; deliver quality and safe viral vector products; and continuously improve manufacturing processes.\nThis position is located in Indianapolis, Indiana (City of Fishers) and will report to the Director of Manufacturing.\nESSENTIAL JOB FUNCTIONS\nProvide leadership, coaching, and mentoring of Upstream manufacturing personnel.\nOversee and execute Vector Upstream Manufacturing activities including the scheduling of resources, material staging, equipment preparation, batch execution, cleaning/sanitization, inventory transactions, and batch record review.\nProvide on the floor training and support for upstream manufacturing operations for clinical viral vector batches.\nHire, coach, and develop Manufacturing team members, including performance management and periodic reviews.\nStrong knowledge of cGMP and GDP requirements for Drug Substance Manufacturing (Viral Vector Manufacturing preferred).\nStrong technical knowledge of both adherent and suspension cell lines including cell thawing, scale-up, bioreactor inoculation, transfection, harvest, and clarification.\nPreferred knowledge and experience with the use and troubleshooting of Cytiva XDR 50L, Cytiva XDR 500L, Univercells Scale-X Carbo, and Cytiva iCELLis 500 bioreactors.\nMonitor and report on area performance, identifying opportunities for improvement and implementing process improvements.\nDesign, implement, maintain, and continuously improve vector manufacturing systems, policies, procedures, and programs that ensure compliance to company and regulatory body standards for Quality and EHS.\nIdentify and mitigate risks in Manufacturing operations that could negatively impact product and personnel safety.\nManage the Manufacturing Production system including but not limited to personnel development, problem solving, investigation of deviations, root cause analysis, CAPAs, Change Controls, 6S, etc.\nEnsure safe working environment and compliance with OSHA, EHS, Quality, and cGMP procedures and policies within the Manufacturing department\nJOB QUALIFICATIONS\nPrior leadership experience in GMP manufacturing facility\nPreferably work experience in a comparable position (similar type of work, similar group dynamics), preferentially in an industrial organization\nAbility to adhere to company internal and regulatory (EMA, FDA) policies, processes, and procedures\nHands -on experience in writing and reviewing the documentation\nExperience in (bio)-manufacturing unit operations\nGood writing and oral communication skills\nThe work schedule may require adjustments to support production activities\nSPECIAL WORK REQUIREMENTS\nAdaptability required as work schedule may change based on business needs\nCriminal background check required\nOther duties as assigned\n\nKNOWLEDGE, SKILLS AND EXPERIENCE\n\nEDUCATION / CERTIFICATIONS / LICENSES\n\nEssential/Desired\n\nBS in Biology, Microbiology, Chemistry, Virology, or any other relevant field of study\n\nDesired\n\nIn-depth knowledge of aseptic processing, GxP, cell culture, and bioreactor operation and troubleshooting\n\nEssential\n\nON-THE-JOB EXPERIENCE\n\n4-6 years of related work experience in a GMP environment\n\nEssential\n\n1 year of supervisory experience\n\nDesired\n\nDrug Substance experience with cell culture and upstream viral vector manufacturing\n\nStrongly Desired\n\nExperience using single use systems\n\nDesired\n\nSKILLS / ABILITIES\n\nDemonstrated interpersonal skills to build relationships, act as change agent, manage conflict, and adapt to rapidly changing organizational and business needs\nEssential\n\nAbility to manage multiple priorities\nEssential\n\nWork Environment:\nFrequently required to work in a BSL 2 environment with personal protective equipment/aseptic gowning\nRegularly required to work around large machinery and typical utilities seen in pharmaceutical facilities\nOccasionally exposed to moving mechanical parts; high, precarious places; toxic or caustic chemicals; hazardous waste; and risk of electrical shock\nOccasionally exposed to extremely loud noise levels\nSpending time on the floor during activity execution (manufacturing, maintenance, construction, commissioning, and qualification) is required\nMovement:\nFrequently required to stand; sit; use hands to finger, handle, or feel; reach with hands and arms\nOccasionally required to walk; climb or balance; and stoop, kneel, crouch, or crawl\nLifting: \nFrequently lift and/or move up to 25 pounds\nOccasionally lift and/or move up to 40-50 pounds\nVision:\nFrequently utilize close vision and the ability to adjust focus\nCorrected 20/20 vision to assist with visual inspection of Drug Products\nCommunication:\nFrequently required to communicate by talking, hearing, using telephone and e-mail\nStrong communication skills to efficiently collaborate and coordinate within manufacturing and cross-functional\nGENEZEN'S CURESVALUE-BASED COMPETENCIES\nCommitted to Science\nWe are committed to scientific excellence, staying current with industry developments, making data-driven decisions, and pursuing innovation to advance healthcare.\nUrgency in action for the patients\nWe operate with urgency and a commitment to delivering timely treatments to patients by accelerating our partners' programs.\nResilience & Grit in operations\nWe are committed to overcoming challenges, learning from failures, and persistently striving for success. \nExecute with Excellence & Integrity\nWe are dedicated to delivering quality results and upholding ethical principals.\nSolutions driven for our partners\nWe are committed to being a proactive, collaborative, creative and open-minded partner.\nGENEZEN'S BENEFITS\nPaid vacation days, amount based on tenure\nPaid sick time\n10 observed holidays + 2 floating holiday + 1 volunteer day\n401(k) plan with company match up to 6% of salary\nShare Appreciation Rights\nChoice of several healthcare plans\nFSA and HSA programs\nDental & vision care\nEmployer-paid basic term life/personal accident insurance\nVoluntary disability, universal life/personal accident insurance\nAccidental Death & Dismemberment (AD&D) Insurance\nADDITIONAL DETAILS\nNothing in the job description for this role restricts management’s right to assign or reassign duties and responsibilities to this job at any time.\nThis position requires a criminal background check.\nGenezen is an Equal Opportunity Employer.\nGenezen participates in EVerify.\nGenezen is interested in every qualified candidate who is eligible to work in the United States; however, we are not able to sponsor visas.\nGenezen has operates two locations: one in Fishers, Indiana and the second in Lexington, Massachusetts. \nFishers is a suburb of Indianapolis. Fishers was named the #1 place to live in the US by Money Magazine in 2017 for its livability, safety and entrepreneurship. Fishers is one of the fastest growing communities in Indiana and is dedicated to supporting a high quality of life for all its residents. Nearby Indianapolis is home to professional and college sports teams, the Indy 500, a growing art community and the world’s largest children’s museum--to name just a few reasons why this area is a great place to live.\nLexington, Massachusetts, located just northwest of Boston, is renowned as a historic suburb with a rich cultural heritage. It boasts picturesque New England charm, tree-lined streets, and a vibrant community. Known for its pivotal role in the American Revolution, Lexington offers visitors and residents alike a blend of historical landmarks, modern amenities, and a strong sense of community pride.","description_format":"text","description_chars":8410,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","CRO & CDMO Services"],"lifecycle":[{"event":"open","at":"2026-09-11T19:41:46Z"},{"event":"close","at":"2026-10-05T20:14:36Z"},{"event":"reopen","at":"2026-10-22T14:12:55Z"}],"visa":[],"liveness":{"score":28,"band":"fade","label":"Fading","p_open":1,"p_active":0.626,"p_room":0.44,"age_days":68,"expected_fill_days":46,"reasons":["conf:0","win:tail","crowd:"],"computed_at":"2026-10-28T05:59:10Z"},"pay":null,"html_url":"https://alion.io/job/genezenlabs-manufacturing-supervisor-upstream","json_url":"https://alion.io/job/genezenlabs-manufacturing-supervisor-upstream.json","meta":{"generated_at":"2026-10-28T06:22:24Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":8368,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-29T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":719970},"rest":"https://alion.io/mcp/rest/get_company?id=719970"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fgenezenlabs-manufacturing-supervisor-upstream"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fgenezenlabs-manufacturing-supervisor-upstream"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fgenezenlabs-manufacturing-supervisor-upstream"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/genezenlabs-manufacturing-supervisor-upstream\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fgenezenlabs-manufacturing-supervisor-upstream"}]}