{"id":4147302,"url":"https://alion.io/job/genscript-manager-lnp-rd","title":"Manager, LNP R&D","company":{"id":4044,"name":"Genscript","domain":"genscript.com","url":"https://alion.io/company/genscript","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":80,"open_postings":64,"ghost_share":0.25,"stale_share":0,"repost_share":0,"time_to_fill_p50_days":68,"computed_at":"2026-11-11T05:49:22Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Seattle, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":125000,"max":160000,"currency":"USD","period":"year","gross":null,"usd_annual":160000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"ELISA","optional":false},{"name":"Flow Cytometry","optional":false},{"name":"qPCR","optional":false},{"name":"Western Blot","optional":false}],"status":"live","first_seen_at":"2026-11-12T07:04:51Z","employer_posted_date":"2026-11-12","last_verified_at":"2026-11-12T07:40:13Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"About GenScript\nFounded in 2002 in New Jersey, GenScript Biotech Corporation accelerates innovation in biotech and healthcare by providing researchers and companies with the building blocks needed to develop groundbreaking treatments and products. Guided by its mission to Make People and Nature Healthier Through Biotechnology, and its role as a well-recognized biotechnology company, GenScript has a team of approximately 6,165 employees and has served more than 200,000 customers across over 100 countries and regions.\nPosition Summary\nGenScript is seeking a highly motivated and experienced scientific leader to lead its Lipid Nanoparticle (LNP) R&D team in Seattle. The successful candidate will bring multidisciplinary expertise in lipid nanoparticles, nucleic acid delivery, formulation development, and RNA therapeutics, together with demonstrated scientific leadership and people-management capability.\nThis role will lead the development and commercialization of innovative RNA and nucleic acid delivery technologies, with a focus on LNP platforms for mRNA, DNA, small RNAs, and other emerging nucleic acid modalities. The team will translate new delivery technologies, formulations, workflows, and operating capabilities into differentiated GenScript products and services for global research and drug-development customers.\nThe ideal candidate is both a scientific innovator and a people leader who can convert emerging delivery technologies into scalable, reproducible, and commercially relevant solutions.\nKey Responsibilities\nScientific and Technology Leadership\nLead the development of innovative LNP and nucleic acid delivery platforms for mRNA, DNA, small RNAs, and other therapeutic payloads across diverse research and therapeutic applications.\nDrive next-generation LNP development, including novel ionizable lipid design and synthesis, formulation optimization, targeted LNPs, extrahepatic delivery, and tissue- or cell-specific delivery strategies.\nEstablish technology roadmaps and development strategies that create differentiated LNP capabilities, products, and services.\nPartner with the RNA R&D team to develop integrated RNA and delivery solutions for vaccines, gene editing, protein replacement, cell engineering, and other emerging applications.\nProvide scientific leadership for LNP formulation design, screening, characterization, optimization, and delivery-performance evaluation.\nMonitor emerging technologies, scientific publications, competitive platforms, intellectual-property trends, and industry developments in nucleic acid delivery.\nTeam Leadership and Development\nBuild, lead, and develop a high-performing LNP R&D team, with responsibility for workforce planning, hiring, resource allocation, budgeting, performance management, and employee development.\nFoster a culture of scientific rigor, innovation, accountability, collaboration, transparency, inclusion, and continuous improvement.\nMentor scientists through regular one-on-one meetings, technical guidance, career-development discussions, and timely, constructive feedback.\nAllocate resources effectively to achieve project milestones, platform-development objectives, and organizational priorities.\nCross-Functional and Project Leadership\nServe as the primary technical and organizational leader for LNP R&D and partner with RNA R&D, Operations, Production, Quality, Marketing, Sales, and Program Management.\nDefine project scope, technical strategy, milestones, resource requirements, risks, and timelines for key R&D programs.\nMonitor project and team performance and communicate progress, risks, scientific findings, and recommendations to senior leadership through project reviews and presentations.\nReview and approve key R&D deliverables, including research reports, experimental protocols, SOPs, technical procedures, production records, presentations, and scientific publications.\nTechnology Transfer and Commercialization\nLead the translation of new LNP technologies from early-stage R&D into robust, scalable, customer-facing products and services.\nProvide technical leadership for formulation scale-up, process optimization, technology transfer, and implementation in Production and Operations.\nWork with Production, Quality, and Operations to establish reproducible processes, critical process parameters, analytical requirements, and fit-for-purpose documentation.\nIdentify opportunities to improve platform performance, operational efficiency, scalability, reproducibility, profitability, and customer value.\nCustomer and Market Engagement\nServe as a technical expert in customer discussions involving LNP formulation, nucleic acid delivery, troubleshooting, and customized development programs.\nPartner with Commercial, Marketing, and Program Management to understand customer needs and translate them into new capabilities and service offerings.\nParticipate in scientific conferences, technical seminars, and customer engagements to identify emerging trends and unmet needs.\nTranslate market and customer insights into actionable R&D priorities and technology roadmaps.\nLaboratory, Quality, and Safety\nOversee the development, implementation, and continuous improvement of laboratory procedures and technical workflows.\nPromote high standards of scientific documentation, experimental reproducibility, data integrity, and laboratory organization.\nEnsure compliance with applicable laboratory-safety requirements and GenScript EHS policies, particularly for lipid chemistry, formulation development, and chemical handling.\nCollaborate with EHS, Quality, and site leadership to maintain a safe and compliant laboratory environment.\nPerform other responsibilities consistent with leading and continuously improving GenScript LNP R&D capabilities.\nRequired Qualifications\nPhD in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, Bioengineering, or a related discipline.\nAt least 5 years of relevant post-PhD industry or research experience in nucleic acid delivery, drug delivery, lipid nanoparticles, or related technologies.\nAt least 2 years of direct people-management experience leading scientific or technical teams, including hiring, coaching, performance management, employee development, and resource planning.\nDeep scientific expertise in lipid nanoparticle formulation and nucleic acid delivery, particularly RNA delivery.\nDemonstrated hands-on experience in LNP formulation, production, optimization, and analytical characterization.\nStrong understanding of lipid-based and/or polymeric nucleic acid delivery technologies.\nExperience with particle size/PDI, zeta potential, encapsulation efficiency, RNA concentration, lipid composition, morphology, and stability assessment.\nExperience evaluating nucleic acid delivery performance in relevant in vitro and/or in vivo models.\nStrong understanding of RNA biology and analytical methods for evaluating RNA quality, delivery, and functional expression.\nExperience with relevant molecular and cellular methods, which may include RT-qPCR, ELISA, Western blotting, flow cytometry, fluorescence-based assays, gel electrophoresis, capillary electrophoresis, and RNA-quantification methods.\nDemonstrated ability to analyze complex data, identify root causes, design effective experiments, and make data-driven development decisions.\nStrong project-management and organizational capabilities, with the ability to manage multiple priorities and development programs.\nExcellent scientific writing, presentation, interpersonal, and stakeholder-management skills.\nAbility to collaborate effectively and influence across technical and business functions without direct authority.\nHigh standards of integrity, scientific rigor, accountability, teamwork, and professional conduct.\nPreferred Qualifications\nExperience in novel ionizable lipid design or synthesis, targeted LNPs, extrahepatic delivery, or cell-specific nucleic acid delivery.\nExperience developing LNPs for mRNA therapeutics, vaccines, gene editing, in vivo cell engineering, siRNA, or other nucleic acid modalities.\nExperience transitioning technologies from early-stage R&D through scale-up, technology transfer, production, or commercial service launch.\nExperience in a CRO/CDMO, biotechnology, pharmaceutical, or life-science service organization.\nExperience working directly with customers, external collaborators, or commercial teams on technical development programs.\nDemonstrated innovation through new technology development, patents, publications, platform development, or successful product/service launches.\nSuccess Profile\nThe successful candidate will combine deep scientific expertise with strong leadership and execution. They will be comfortable moving between hands-on scientific problem-solving, technology strategy, team development, cross-functional execution, and customer engagement. Most importantly, they will bring scientific curiosity, ownership, creativity, and urgency to building next-generation LNP technologies that strengthen GenScript's global RNA and nucleic acid delivery capabilities.\nPerks: \nFree colleague meals during shift\nOnsite gyms\nCompensation:\nSalary range: $125,000 - $160,000 total compensation, including bonus, depending on experience and qualifications.\nBenefits:\nBenefits include medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and company holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.\nGenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.\nGenScript USA Inc./ProBio Inc. maintains a drug-free workplace.\nPlease note: Genscript USA Inc./ProBio Inc. will only contact candidates through verified application sources. 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