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GRAIL

GRAIL is a healthcare company pioneering new technologies to advance early cancer detection. Discover our mission to detect cancer early, when it can be cured.

We are seeking a visionary and execution-focused Director of Software Engineering to lead our Data Platform engineering organization. In this role, you will drive the technical strategy, architecture, and delivery of our next-generation, cloud-native data platform.

The ideal candidate brings over 15 years of software engineering experience, combining deep technical expertise in big data, cloud infrastructure, and AI-driven workflows (including RAG and LLM applications) with a proven track record of scaling engineering teams (10+ headcount). You will collaborate closely with cross-functional executives to translate complex domain requirements into scalable, secure, and compliant production-grade software.

This role is based in Sunnyvale, California. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site. At our Sunnyvale campus, Tuesdays and Thursdays are the key days where we encourage on-site presence to engage in events and on-site activities but candidates must be flexible based on the needs of the business.

Responsibilities

    Engineering & Organizational Leadership

  • Team Scaling & Culture: Lead, mentor, and scale a multi-disciplinary global engineering organization, fostering a culture of high performance, continuous learning, and technical excellence.

  • Strategic Roadmap Delivery: Own the technical roadmap and resource allocation, ensuring 95%+ on-time execution of strategic product milestones.

  • Agile Transformation: Champion and mature Agile/Scrum methodologies to optimize feature velocity, minimize product turnaround time, and maintain high software quality.

  • Strategic Technical Architecture & Data Innovation

  • Cloud-Native Evolution: Architect, govern, and optimize the transition to modern serverless and microservices architectures on AWS, driving structural cost optimization and system elasticity.

  • Big Data Ecosystems: Define the strategy for next-generation big data platforms utilizing Snowflake, Databricks, Apache Iceberg, AWS Glue, etc. to process, partition, and index petabyte-scale datasets.

  • Performance Engineering: Oversee analytical and search data model optimizations to continually improve query performance and data pipeline throughput.

  • AI & Product Modernization

  • AI-Driven Initiatives: Direct the integration of AI-assisted SDLC tools and architect LLM-enabled product features, including RAG-based semantic search and conversational search workflows.

  • API & System Interoperability: Oversee the development of high-throughput ETL pipelines and secure, scalable RESTful APIs built on Java / Spring Boot to ensure global data interoperability.

  • Operational Excellence & Compliance

  • DevOps & SRE Practices: Mature CI/CD automation pipelines using infrastructure-as-code (Terraform, Ansible, Jenkins) to automate provisioning and security patching.

  • Security & Compliance: Ensure all platforms strictly adhere to modern cybersecurity standards and regulatory compliance frameworks (e.g., GDPR, HIPAA).

Required Qualifications

    Leadership & Soft Skills

  • 15+ years of progressive experience in software engineering, with 5+ years in a dedicated engineering leadership role managing cross-functional, global teams.

  • Proven ability to interface with executive stakeholders (Product, UX, Architecture) to align engineering outputs with business growth.

  • Strong experience managing large operational budgets and implementing strategic cloud cost-optimization practices.

  • Technical Stack & Domain Expertise

  • Backend & Architecture: Expert-level knowledge of Java, Spring Boot, Spring MVC, distributed systems design, database sharding, and high-performance microservices.

  • Data & Analytics: Deep proficiency with Snowflake, Apache Iceberg, AWS Glue, Spark, and Elasticsearch.

  • AI & Search: Hands-on architecture experience with Retrieval-Augmented Generation (RAG), Large Language Model (LLM) frameworks, and semantic/conversational search.

  • Cloud & DevOps: Strong expertise in AWS Cloud infrastructure, containerization, and IaC tools (Terraform, Ansible, Jenkins).

  • Domain Interoperability: Experience in high-volume, regulated data fields (e.g., genomics, healthcare, bioinformatics, or fintech) and data standards (e.g., GA4GH) is highly desirable.

  • Education

  • Master’s Degree in Computer Science, Software Engineering, or a highly related technical field preferred.

  • Bachelor’s Degree in Computer Science or Engineering or equivalent practical experience.

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Work setup

Location
Sunnyvale
Remote work
In office
Employment
Full-Time

Compensation

Benefits
Continuous learning, Flexible schedule