{"id":1520790,"url":"https://alion.io/job/haya-therapeutics-research-associate-i","title":"Research Associate I","company":{"id":1861274,"name":"HAYA Therapeutics","domain":"hayatx.com","url":"https://alion.io/company/hayatx","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workable","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Diego, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":70000,"max":90000,"currency":"USD","period":"year","gross":null,"usd_annual":90000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-09-30T11:46:56Z","employer_posted_date":"2026-09-30","last_verified_at":"2026-10-18T20:32:17Z","board_verified":true,"closed_at":null,"days_open":18,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":18},"description":"At HAYA Therapeutics, we are pioneering a new class of programmable RNA-guided therapeutics that target the regulatory genome to reprogram disease-driving cell states. By decoding the causal biology of pathological cell states and the long-noncoding RNAs (lncRNAs) that regulate them, HAYA translates these insights into tractable therapeutic candidates designed to address disease at its source and restore cellular health. HAYA is advancing a broad pipeline of RNA-guided medicines for chronic, age-related diseases.\nRecognized globally for our scientific innovation, HAYA has been named a 2025 Technology Pioneer by the World Economic Forum (WEF), selected for BioSpace's NextGen Bio Class of 2026, recognized as a 2026 Disruptive Pioneer by IDEA Pharma, and celebrated as one of the Top Innovative Companies in Switzerland for 2025. As a fast-growing biotech, we offer an entrepreneurial, science-driven environment where you’ll have a direct impact on shaping our pipeline and advancing RNA medicine\n1. Purpose:\nExecute preclinical cellular assays, tissue histology, nucleic acid extractions, and spatial transcriptomics protocols to generate high-quality experimental data supporting HAYA's functional genomics and lncRNA target validation pipelines.\n2. Accountabilities\nPrimary Cell Culture & ASO Screening Execution\n·Execute primary cell isolation, tissue culture, and cell line maintenance (including human and mouse fibroblasts, C2C12 cells, myoblasts, and satellite cells) to establish robust in vitro disease models. \nPerform compound treatments and antisense oligonucleotide (ASO) screening protocols (including GapmeRs and siRNA) across primary cell platforms to evaluate target knocking-down efficiency and therapeutic potency. \nIsolate and process RNA, DNA, and proteins from cellular and tissue specimens using standardized extraction techniques to prepare high-integrity samples for downstream molecular profiling. \nTissue Histology & Spatial Transcriptomics\nPerform tissue processing, FFPE embedding, sectioning, and staining protocols (including immunohistochemistry and immunofluorescence) to quantify fibrotic markers and evaluate tissue morphology. \nExecute spatial transcriptomics and multi-omics assay workflows in alignment with functional genomics protocols to characterize spatial gene expression in target tissues. \nCapture and analyze fluorescence microscopy images across immunostained and spatial transcriptomic tissue sections to extract qualitative and quantitative cellular insights. \nPreclinical Model Support & Data Governance\nSupport in vivo preclinical study workflows by assisting with tissue dissections and sample collection from skeletal mouse and disease models to supply downstream experimental workstreams. \nMaintain detailed, real-time Electronic Lab Notebook (ELN) records, SOPs, and experimental documentation to ensure absolute data traceability, reproducibility, and audit readiness. \nSynthesize, analyze, and present experimental dataset summaries to internal R&D project teams and scientific leadership to inform ongoing pipeline decision-making. \nRequirements\n3. Required Knowledge and Experience\nEssential Qualifications & Technical Capabilities (Must-Haves)\nCell Culture & Primary Model Proficiency: Demonstrated capability in primary cell isolation, propagation, and differentiation, with specific expertise in mammalian cell lines or primary fibroblasts/myoblasts. \nMolecular Biology & ASO Screening Techniques: Practical experience performing nucleic acid extractions (RNA/DNA), PCR, and compound/ASO transfection screenings. \nHistology & Imaging Capabilities: Hands-on experience with tissue sectioning (FFPE/cryosectioning), histology staining, immunofluorescence (IF), or fluorescence microscopy. \nPreclinical Sample Handling: Comfortable handling animal tissue samples from vivarium studies and maintaining strict chain-of-custody documentation. \nTechnical Agility & Documentation Rigor: Proven ability to rapidly adopt new laboratory protocols, operate digital ELNs, and maintain meticulous attention to experimental detail. \nEducational Foundation: Bachelor’s or Master’s degree in Molecular Biology, Cellular Biology, Biotechnology, Biochemistry, or a related life sciences discipline. \nDesirable Experience & Specialized Expertise (Nice-to-Haves)\nNext-Generation Sequencing (NGS) & Multi-Omics: Familiarity with NGS library preparation (RNA-seq, single-cell RNA-seq) or spatial transcriptomics platforms. \nExperience with automated liquid handling systems or other laboratory automation platforms.\nRNA Biology & Fibrosis Research: Background understanding of long non-coding RNA (lncRNA) biology, oligonucleotide therapeutics, or fibrotic disease mechanisms. \nLeadership Profile\nThe successful candidate will demonstrate:\nMeticulous Precision & Rigor: Drives high quality and consistency in laboratory execution, maintaining absolute accuracy across extractions, assays, and notebooks. \nAdaptable Learning Mindset: Proactively seeks opportunities to master cutting-edge genomic techniques and workflow optimizations. \nCollaborative Team Orientation: Communicates transparently, supports peers across laboratory disciplines, and aligns daily tasks with broader company goals.\nNotice to Recruitment Agencies & Search Firms:\nHAYA Therapeutics operates a Preferred Supplier List (PSL) and manages all recruitment directly through our Human Resources team. We do not accept unsolicited resumes or speculative CVs from third-party agencies, search firms, or recruiters. Any unsolicited candidates or CVs submitted through non-approved channels, directly to HAYA employees, or without a fully executed recruitment agreement in place will be considered property of HAYA Therapeutics. HAYA Therapeutics will not pay any fee, liability, or finder's fee for candidates submitted under these circumstances.\nHAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws. We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics.\nSalary Range: $70,000 to $90,000\nBenefits\nWhat we offer (California)\nHealth & Wellbeing\nMedical coverage through Anthem Blue Cross and Cigna, with HMO, PPO and high-deductible (HSA-eligible) plan options. Haya covers 91-95% of premiums for you and your dependents.\nHaya contributes to your Health Savings Account when you choose a high-deductible plan: $142/month for employee-only coverage, $284/month with dependents.\nDental (Guardian, Basic and Premier plans) and vision coverage, with Haya covering 91% of premiums.\nCoverage begins on the first of the month after your start date.\nEmployee Assistance Program (EAP) for confidential counselling and support.\nAccess to One Medical and travel assistance through Guardian Assist America.\nFinancial Protection & Security\n401(k) through Empower, with Haya matching 100% of your contributions up to 4% of salary. You can join from day one and are fully vested in the match immediately.\nEligibility for discretionary bonus and stock option programs.\nCompany-paid life and AD&D insurance ($50,000).\nCompany-paid short-term and long-term disability insurance (60% income replacement).\nPre-tax Flexible Spending Accounts (healthcare, limited-purpose and dependent care) and commuter benefits.\nOptional Coverage\nSupplemental life, accident, critical illness, hospital indemnity, legal services, identity theft protection and pet insurance.\nFinancial wellness resources, including mortgage, budgeting and student loan support.\nTime Off\n15 days of paid vacation per year.\n10 paid company holidays, including the day after Thanksgiving and Christmas Eve.\n5 days of paid sick leave, available in full at the start of each year.\n5 days of paid bereavement leave.","description_format":"text","description_chars":8545,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"master","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Bioinformatics","Molecular Diagnostics","Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-09-30T11:46:56Z"}],"visa":[],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.696,"p_room":0.9,"age_days":16,"expected_fill_days":33,"reasons":["conf:0","win:mid"],"computed_at":"2026-10-17T05:46:00Z"},"pay":{"stated_usd_annual":90000,"is_top_pay":false},"html_url":"https://alion.io/job/haya-therapeutics-research-associate-i","json_url":"https://alion.io/job/haya-therapeutics-research-associate-i.json","meta":{"generated_at":"2026-10-18T20:35:27Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":24400,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-19T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1861274},"rest":"https://alion.io/mcp/rest/get_company?id=1861274"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fhaya-therapeutics-research-associate-i"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fhaya-therapeutics-research-associate-i"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fhaya-therapeutics-research-associate-i"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/haya-therapeutics-research-associate-i\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fhaya-therapeutics-research-associate-i"}]}