{"id":2960349,"url":"https://alion.io/job/helix-staff-bioinformatics-engineer-clinical-applications","title":"Senior/ Staff Bioinformatics Engineer, Clinical Applications","company":{"id":1864201,"name":"Helix","domain":"helix.com","url":"https://alion.io/company/helix-com","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Gem","truth_index":null},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"staff","employment_type":"full_time","work_mode":"remote","remote_scope":"stated_countries","remote_scope_basis":"board_field","remote_working_hours":null,"hiring_geo_confidence":"structured","locations":[],"countries":[],"hiring_countries":["US"],"hiring_countries_total":1,"salary":{"min":161500,"max":219625,"currency":"USD","period":"year","gross":null,"usd_annual":219625},"salary_estimate":null,"experience_years_min":9,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"AI Agents","optional":false},{"name":"AWS","optional":false},{"name":"LangChain","optional":false},{"name":"LangGraph","optional":false},{"name":"Next-Generation Sequencing","optional":false},{"name":"PubMed","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-10-15T18:53:48Z","employer_posted_date":"2026-10-21","last_verified_at":"2026-10-25T06:08:31Z","board_verified":true,"closed_at":null,"days_open":9,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":9},"description":"Who We Are & What We Do\nAt Helix, our mission is simple: to help everyone improve their lives through their DNA.\nReady to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.\nWhat is special about this role?\nYou'll bridge the gap between genomic variants and the clinical answers that help patients act on their DNA. You'll partner with scientists and product leaders to turn promising prototypes into production systems that scale. Your code will power how Helix automates gene and variant curation for real patients.\nWe have openings for both Senior and Staff level Engineers. You may apply at either level, and we’ll consider your experience, qualifications and demonstrated scope when determining the right level.\nAs a Senior/Staff Bioinformatics Engineer, Clinical Applications, you will:\nProductionize curation workflows that support both classical and modern AI/ML approaches to variant classification.\nAutomate evidence integration from sources such as ClinVar, gnomAD, and PubMed.\nCollaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements.\nDirect AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment.\nAt Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems.\nAt Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area.\nAbout you:\nBachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience. Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience.\nAdvanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS.\nExperience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph.\nExperience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows.\nStrong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production.\nPluses:\nExperience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms.\nExperience developing regulated software, such as software as a medical device.\nAt Staff level, the role may have the opportunity to take on people leadership responsibilities. Experience mentoring or managing others, or an interest in developing as a people leader, is a plus.\nExpected Interview Process:\n1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer\nExpected Pay For This Role:\nThere are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity\nExpected Helix Base: $161,500 - $219,625\nExpected Helix Discretionary Annual Bonus: 15% of your annual salary\nEquity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.\nAside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:\nComprehensive Health Insurance with Date of Hire eligibility Above average employer paid premium coverage \n\n12 weeks Helix Paid Parental Leave option \n401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire\nComprehensive Well-Being Benefits \nFlexible PTO\nRemote options for many roles and a home office stipend \nWhat To Expect During Your First 90 days:\nFirst 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.\nDay 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities. \nDay 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.\nTo learn how Helix collects, uses, and protects your personal information during the recruitment process, please review our Privacy Notice.\nHelix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws. \n #LI-Remote\nCompensation\nThe base pay range for this role is $134,000 - $179,000 per year.","description_format":"text","description_chars":5617,"description_truncated":false,"requirements":{"experience_years_min":9,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity","Health insurance","Home office","Parental leave"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Bioinformatics","Biotechnology","Health Care","Genomics & Genetic Testing"],"lifecycle":[{"event":"open","at":"2026-10-20T22:42:52Z"}],"visa":[],"liveness":{"score":70,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.74,"p_room":0.945,"age_days":9,"expected_fill_days":27,"reasons":["conf:3","win:mid"],"computed_at":"2026-10-25T05:49:26Z"},"pay":{"stated_usd_annual":219625,"is_top_pay":true},"html_url":"https://alion.io/job/helix-staff-bioinformatics-engineer-clinical-applications","json_url":"https://alion.io/job/helix-staff-bioinformatics-engineer-clinical-applications.json","meta":{"generated_at":"2026-10-25T08:41:25Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12315,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-26T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1864201},"rest":"https://alion.io/mcp/rest/get_company?id=1864201"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fhelix-staff-bioinformatics-engineer-clinical-applications"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fhelix-staff-bioinformatics-engineer-clinical-applications"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fhelix-staff-bioinformatics-engineer-clinical-applications"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/helix-staff-bioinformatics-engineer-clinical-applications\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fhelix-staff-bioinformatics-engineer-clinical-applications"}]}