{"id":2579855,"url":"https://alion.io/job/hims-hers-supervisor-cgmp-manufacturing-upstream-downstream","title":"Supervisor, CGMP Manufacturing (Upstream / Downstream)","company":{"id":6261,"name":"Hims & Hers","domain":"hims.com","url":"https://alion.io/company/hims","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"A","score":88,"open_postings":4,"ghost_share":0,"stale_share":0.5,"repost_share":0,"time_to_fill_p50_days":47,"computed_at":"2026-10-21T05:46:15Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Menlo Park, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":100000,"max":120000,"currency":"USD","period":"year","gross":null,"usd_annual":120000},"salary_estimate":null,"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-10-14T22:19:00Z","employer_posted_date":"2026-10-14","last_verified_at":"2026-10-21T06:25:31Z","board_verified":true,"closed_at":null,"days_open":6,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":6},"description":"Hims & Hers is the leading health and wellness platform, on a mission to help the world feel great through the power of better health. We are redefining healthcare by putting the customer first and delivering access to care that is affordable, accessible, and personal, from diagnosis to treatment to delivery. No two people are the same, so we provide access to personalized care designed for results. By normalizing health & wellness challenges and innovating on their solutions, we’re making better health outcomes easier to achieve.\nHims & Hers is a public company, traded on the NYSE under the ticker symbol “HIMS.” To learn more about the brand and offerings, you can visit hims.com/about and hims.com/how-it-works . For information on the company’s outstanding benefits, culture, and its talent-first flexible/remote work approach, see below and visit www.hims.com/careers-professionals.\nAbout the Role:\nThe Supervisor, CGMP Manufacturing - Downstream leads day-to-day downstream peptide production at our cGMP facility, including preparative HPLC purification, lyophilization, and final packaging, delivering purified peptide API safely, on schedule, and in compliance with cGMP.\nThis is a hands-on role reporting to the Operations Manager, with direct authority over downstream production staff, scheduling, and floor execution. You will work closely with your upstream counterpart to hand off material smoothly and keep campaigns on schedule.\nThis role is based in Menlo Park, CA at our H&H Peptides facility.\nYou Will:\nUpstream Execution:\nDirect cGMP SPPS operations, including resin preparation, coupling and deprotection cycles, in-process checks, and resin washing and drying.\n\nDirect cleavage operations, including cocktail preparation, cleavage, filtration, precipitation, and isolation of crude peptide.\n\nEnsure upstream execution follows approved batch records, SOPs, and safety requirements, including safe handling of hazardous solvents and reagents (e.g., DMF, piperidine, TFA).\n\nDownstream Execution:\nDirect cGMP purification operations, including prep HPLC column packing and equilibration, loading, gradient runs, fraction collection, and pooling.\n\nDirect lyophilization and final isolation operations, including cycle execution, unloading, and final packaging and labeling.\n\nEnsure downstream execution follows approved batch records, SOPs, and safety requirements, and coordinate with QC on in-process and release testing.\n\nEquipment & Floor Operations:\nOversee equipment readiness across upstream and downstream, including synthesizers, cleavage vessels, prep HPLC systems, lyophilizers, and packaging equipment, in coordination with Engineering and Maintenance.\n\nOversee equipment qualification, preventive maintenance, and vendor relationships.\n\nTroubleshoot issues on the floor in real time and escalate appropriately.\n\nScheduling:\nBuild and manage the integrated upstream and downstream production schedule, balancing synthesizer, vessel, column, and lyophilizer capacity, staffing, material availability, and QC turnaround.\n\nPlan campaigns across multiple concurrent products, and own schedule attainment and on-time delivery.\n\nCoordinate the hand-off of crude peptide from upstream to downstream, and work with Supply Chain and Quality to keep batches moving.\n\nProcess, Quality & Continuous Improvement:\nLead investigations of deviations, failed batches, and process excursions; conduct root cause analysis and implement corrective and preventive actions.\n\nAuthor, review, and maintain master batch records, SOPs, and work instructions in partnership with Quality and Process Development.\n\nSupport scale-up, tech transfer, and new product introductions, including process validation and PPQ campaigns, in partnership with Process Development.\n\nDrive yield, throughput, and cost-efficiency improvements, using process data and historical performance to set targets.\n\nSupport the design, implementation, and continuous improvement of manufacturing systems, including electronic batch records, keeping them compliant, practical, and easy for front-line teams to use.\n\nAudit Readiness & Compliance:\nKeep the area inspection-ready at all times; ensure batch records, logbooks, and equipment records are complete, accurate, and compliant with ALCOA+ and 21 CFR Part 11.\n\nEnsure manufacturing operations comply with cGMP, internal SOPs, and master batch records per 21 CFR 210/211 and ICH Q7.\n\nSupport audits and regulatory inspections, including preparing the area, hosting walkthroughs, and owning responses, CAPAs, and follow-up commitments through on-time completion.\n\nProvide manufacturing data and documentation to support regulatory submissions, ensuring data integrity.\n\nTeam Development:\nLead, coach, and develop chemists, operators, and technicians across upstream and downstream; set clear expectations and performance metrics, and conduct regular performance reviews.\n\nOwn onboarding and GMP training, maintain training matrices and qualifications, and build cross-training and shift coverage.\n\nLead hands-on: understand operations at the task level, observe workflows to find bottlenecks, and help solve problems directly on the floor when needed.\n\nFoster a culture of safety, initiative, accountability, and open communication where issues are raised early and resolved promptly.\n\nYou Have:\nBachelor’s degree in chemistry, Biochemistry, Chemical Engineering, or a related discipline.\n\n3+ years of cGMP manufacturing experience in pharmaceutical, biopharmaceutical, or peptide manufacturing\n\nHands-on experience with preparative HPLC purification and lyophilization\n\n1+ years in a leadership or supervisory role managing production teams\n\nStrong working knowledge of cGMP batch execution, deviations, CAPAs, and data integrity.\n\nStrong problem-solving, communication, and organizational skills in a small, fast-moving environment.\n\nPreferred Qualifications:\nExperience with commercial-scale SPPS (upstream) or prep HPLC and lyophilization (downstream).\n\nExperience supporting process validation, PPQ campaigns, and tech transfer of new peptide products into GMP manufacturing.\n\nExperience with budget oversight, capital projects, vendor management, and staffing.\n\nExperience with MES/electronic batch record systems and continuous improvement initiatives.\n\nOur Benefits (there are more but here are some highlights):\nCompetitive salary & equity compensation for full-time roles\n\nUnlimited PTO, company holidays, and quarterly mental health days\n\nComprehensive health benefits including medical, dental & vision, and parental leave\n\nEmployee Stock Purchase Program (ESPP)\n\n401k benefits with employer matching contribution\n\nOffsite team retreats\n\nWe are committed to building a workforce that reflects diverse perspectives and prioritizes ethics, wellness, and a strong sense of belonging. If you're excited about this role, we encourage you to apply-even if you're not sure if your background or experience is a perfect match.\nHims considers all qualified applicants for employment, including applicants with arrest or conviction records, in accordance with the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance, the California Fair Chance Act, and any similar state or local fair chance laws.\nIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.\nHims & Hers is committed to providing reasonable accommodations for qualified individuals with disabilities and disabled veterans in our job application procedures. If you need assistance or an accommodation due to a disability, please contact us at  and describe the needed accommodation. Your privacy is important to us, and any information you share will only be used for the legitimate purpose of considering your request for accommodation. Hims & Hers gives consideration to all qualified applicants without regard to any protected status, including disability. Please do not send resumes to this email address.\nTo learn more about how we collect, use, retain, and disclose Personal Information, please visit our Global Candidate Privacy Statement.","description_format":"text","description_chars":8269,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Equity","Parental leave","Unlimited PTO"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Telemedicine & Virtual Care","Pharmacies"],"lifecycle":[{"event":"open","at":"2026-10-15T01:29:36Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 26 · green card filings: 6","filings_12m":26,"filings_prev_12m":18,"green_card_filings_12m":6,"median_offered_wage_usd":155000,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":6,"expected_fill_days":47,"reasons":["conf:2","velocity","win:early","comp:brand"],"computed_at":"2026-10-21T05:46:15Z"},"pay":{"stated_usd_annual":120000,"is_top_pay":true},"html_url":"https://alion.io/job/hims-hers-supervisor-cgmp-manufacturing-upstream-downstream","json_url":"https://alion.io/job/hims-hers-supervisor-cgmp-manufacturing-upstream-downstream.json","meta":{"generated_at":"2026-10-21T07:53:27Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":11227,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":6261},"rest":"https://alion.io/mcp/rest/get_company?id=6261"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fhims-hers-supervisor-cgmp-manufacturing-upstream-downstream"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fhims-hers-supervisor-cgmp-manufacturing-upstream-downstream"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fhims-hers-supervisor-cgmp-manufacturing-upstream-downstream"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/hims-hers-supervisor-cgmp-manufacturing-upstream-downstream\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fhims-hers-supervisor-cgmp-manufacturing-upstream-downstream"}]}