{"id":139910,"url":"https://alion.io/job/iambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training","title":"Machine Learning Scientist — Large Multimodal Models (Post-Training)","company":{"id":4891,"name":"Iambic Therapeutics","domain":"iambictherapeutics.com","url":"https://alion.io/company/iambictherapeutics","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"B","score":74,"open_postings":6,"ghost_share":0,"stale_share":0.833,"repost_share":0,"time_to_fill_p50_days":71,"computed_at":"2026-10-21T05:46:15Z"}},"role":"AI/ML","role_family":"AI/ML","seniority":null,"employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Bristol, United Kingdom"],"countries":["GB"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CUDA","optional":false},{"name":"Docker","optional":false},{"name":"Fine-tuning","optional":false},{"name":"GRPO","optional":false},{"name":"HPC","optional":false},{"name":"Kubernetes","optional":false},{"name":"LoRA","optional":false},{"name":"Machine Learning","optional":false},{"name":"Multimodal AI","optional":false},{"name":"Optuna","optional":false},{"name":"Post-training","optional":false},{"name":"PPO","optional":false},{"name":"Python","optional":false},{"name":"PyTorch","optional":false},{"name":"Quantization","optional":false},{"name":"Ray Tune","optional":false},{"name":"Reinforcement Learning","optional":false},{"name":"RLAIF","optional":false},{"name":"RLHF","optional":false},{"name":"SFT","optional":false},{"name":"Weights & Biases","optional":false},{"name":"PEFT","optional":true},{"name":"Ray","optional":true}],"status":"live","first_seen_at":"2026-08-27T21:37:28Z","employer_posted_date":"2026-08-27","last_verified_at":"2026-10-21T21:02:53Z","board_verified":true,"closed_at":null,"days_open":54,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":54},"description":"JOB SUMMARY\nWe are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.\nThe role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.\nWe are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Bristol office.\nKEY RESPONSIBILITIES\nResearch and develop post-training strategies for large-scale multimodal foundation models\n\nDesign reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs\n\nBuild systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies\n\nDevelop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows\n\nDesign and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases\n\nCollaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services\n\nPartner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs\n\nCommunicate results to internal teams, external partners, and at conferences\n\nWrite high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity\n\nQUALIFICATIONS\nPhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth\n\nStrong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end\n\nDemonstrated experience training large-scale transformer models\n\nDemonstrated experience in one or more of the following:\n\nReinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)\n\nSupervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods\n\nSystematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks\n\nStrong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging\n\nComfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)\n\nPREFERRED\nExperience with multimodal or multi-task model architectures\n\nTraining and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)\n\nFamiliarity with biomedical, chemical, or biological data domains\n\nDistributed training at scale\n\nHPC or large-scale training operations experience\n\nABOUT IAMBIC THERAPEUTICS\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.\nMISSION & CORE VALUES\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\nPAY AND BENEFITS\nWe offer a competitive compensation package, private medical insurance, life assurance, pension contributions, and flexible holiday allowances to our team. Our UK office provides a modern and collaborative work environment, right in the centre of Bristol.","description_format":"text","description_chars":5516,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Health insurance"],"hiring_locations":[{"name":"United Kingdom","iso":"GB","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Drug Discovery","Drug Discovery AI"],"lifecycle":[{"event":"open","at":"2026-08-27T21:37:28Z"}],"visa":[],"liveness":{"score":53,"band":"ok","label":"Likely open","p_open":1,"p_active":0.713,"p_room":0.75,"age_days":54,"expected_fill_days":71,"reasons":["conf:3","win:late"],"computed_at":"2026-10-21T05:46:15Z"},"pay":null,"html_url":"https://alion.io/job/iambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training","json_url":"https://alion.io/job/iambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training.json","meta":{"generated_at":"2026-10-21T21:14:17Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":30159,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4891},"rest":"https://alion.io/mcp/rest/get_company?id=4891"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fiambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fiambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fiambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/iambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fiambic-therapeutics-machine-learning-scientist-large-multimodal-models-post-training"}]}