{"id":582836,"url":"https://alion.io/job/iambic-therapeutics-senior-associate-scientist-iii-purification-sciences","title":"Senior Associate Scientist I/II, Purification Sciences","company":{"id":4891,"name":"Iambic Therapeutics","domain":"iambictherapeutics.com","url":"https://alion.io/company/iambictherapeutics","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":{"grade":"A","score":92,"open_postings":6,"ghost_share":0,"stale_share":0.333,"repost_share":0,"time_to_fill_p50_days":47,"computed_at":"2026-10-25T05:49:26Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Diego, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":88000,"max":128000,"currency":"USD","period":"year","gross":null,"usd_annual":128000},"salary_estimate":null,"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":false},{"name":"Mass Spectrometry","optional":true}],"status":"live","first_seen_at":"2026-09-09T23:26:11Z","employer_posted_date":"2026-09-09","last_verified_at":"2026-10-25T08:10:09Z","board_verified":true,"closed_at":null,"days_open":45,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":45},"description":"JOB SUMMARY\nWe are seeking a motivated and hands-on Senior Associate Scientist I/II, Purification Sciences to support small-molecule drug discovery. This individual will perform chromatography-based purification, with a focus on preparative LC and preparative SFC, supporting medicinal chemistry and high-throughput chemistry efforts.\nThe ideal candidate will have practical laboratory experience with chromatographic purification and a strong interest in developing expertise in separation science, instrumentation, and high-throughput purification workflows. Experience with instrument maintenance and troubleshooting is highly desirable. This position will be based in our San Diego Headquarters.\nKEY RESPONSIBILITIES\nPerform routine and moderately complex small-molecule purification using preparative LC and SFC, supporting medicinal chemistry and high-throughput chemistry workflows.\n\nDevelop and optimize purification methods, including column/mobile-phase selection, gradients, sample loading, and fraction collection.\n\nOperate prep LC, prep SFC, analytical LC, and LC/MS systems and perform analytical QC of purified compounds.\n\nPerform routine instrument maintenance and troubleshoot common chromatography, fluidics, hardware, and software issues.\n\nMonitor instrument performance and proactively identify issues to maintain reliable laboratory operations and minimize downtime.\n\nSupport high-throughput and automated purification workflows, including sample submission, purification, fraction handling, compound recovery, and data reporting.\n\nWork closely with medicinal chemists and other scientists to prioritize samples and deliver purified compounds with appropriate purity, recovery, and turnaround time.\n\nSupport evaluation and implementation of new purification methods, columns, instrumentation, and workflow improvements.\n\nMaintain accurate experimental and instrument documentation and contribute to laboratory best practices.\n\nQUALIFICATIONS\nB.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience\n\nRelevant hands-on laboratory experience in chromatography and small-molecule purification; level will be determined based on experience and demonstrated technical capabilities.\n\nWorking knowledge of chromatographic separation principles and method optimization.\n\nStrong attention to detail, problem-solving skills, and ability to work effectively in a fast-paced, collaborative research environment.\n\nPREFERRED QUALIFICATIONS\nExperience with preparative LC and/or preparative SFC is strongly preferred; SFC experience is highly desirable.\n\nExperience operating and troubleshooting chromatography instrumentation is strongly preferred.\n\nExperience with LC/MS-based characterization and purity assessment is desirable.\n\nExperience with automated or high-throughput laboratory workflows is desirable.\n\nExperience with Agilent, Shimadzu, SCIEX, or comparable platforms is a plus.\n\nABOUT IAMBIC THERAPEUTICS\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.\nMISSION & CORE VALUES\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\nPAY AND BENEFITS\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","description_format":"text","description_chars":4549,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["401k plan","Life insurance"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Drug Discovery","Drug Discovery AI"],"lifecycle":[{"event":"open","at":"2026-09-10T00:10:34Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 1","filings_12m":1,"filings_prev_12m":0,"green_card_filings_12m":0,"median_offered_wage_usd":147500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":41,"band":"fade","label":"Fading","p_open":1,"p_active":0.68,"p_room":0.6,"age_days":45,"expected_fill_days":47,"reasons":["conf:1","win:late","crowd:junior"],"computed_at":"2026-10-25T05:49:26Z"},"pay":{"stated_usd_annual":128000,"is_top_pay":true},"html_url":"https://alion.io/job/iambic-therapeutics-senior-associate-scientist-iii-purification-sciences","json_url":"https://alion.io/job/iambic-therapeutics-senior-associate-scientist-iii-purification-sciences.json","meta":{"generated_at":"2026-10-25T08:25:45Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12000,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-26T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":4891},"rest":"https://alion.io/mcp/rest/get_company?id=4891"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fiambic-therapeutics-senior-associate-scientist-iii-purification-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fiambic-therapeutics-senior-associate-scientist-iii-purification-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fiambic-therapeutics-senior-associate-scientist-iii-purification-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/iambic-therapeutics-senior-associate-scientist-iii-purification-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fiambic-therapeutics-senior-associate-scientist-iii-purification-sciences"}]}